ABSTRACT
Two cases of human pulmonary adiaspiromycosis are reported. Patients were 29 and 54-year-old males, farm workers, with "grippe-like" symptoms and radiographic findings suggestive of granulomatous interstitial disease. Transthoracoscopic and transbronchial biopsies were performed. Pulmonary function was measured by spirometry. One patient used ketoconazole. Possibility of misdiagnosed pulmonary adiaspiromycosis is emphasized.
Subject(s)
Chrysosporium , Lung Diseases, Fungal/diagnosis , Adult , Humans , Male , Middle AgedABSTRACT
Anatomo-pathological correlation in a case of systemic talc granulomatosis affecting lungs, pleura, liver, spleen and mesenteric lymph nodes resulting in pulmonary arterial hypertension and cor pulmonale is described. The patient, a 26-year-old male HIV-negative intravenous drug addict had no lymphopenia or any histopathologic findings at necroscopy compatible with AIDS, despite of a chronic high-risk behavior favoring this illness.
Subject(s)
Granuloma, Foreign-Body/etiology , Granuloma, Foreign-Body/pathology , Substance Abuse, Intravenous/complications , Talc/adverse effects , Adult , Fatal Outcome , Humans , MaleABSTRACT
É descrita a correlação anatomopatológica de um paciente usuário de drogas injetáveis com talcose sistêmica acometendo pulmões, pleuras, fígado, baço e linfonodos e que desenvolveu hipertensão arterial pulmonar e cor pulmonale. Destaca-se o fato de que apesar do uso crônico de drogas injetáveis e outros comportamentos de alto risco para infecção pelo retrovírus, o paciente era HIV negativo, não apresentava linfocitopenia, nem alterações histopatológicas compatíveis com AIDS à necropsia.
Subject(s)
Adult , Humans , Male , Talc/adverse effects , Granuloma, Foreign-Body/etiology , Granuloma, Foreign-Body/pathology , Substance Abuse, Intravenous/complications , Fatal OutcomeABSTRACT
One thousand seven hundred and eight chronic chagasic post-mortem examinations studied from a total of 4690 autopsies performed at our Institution. Two hundred and seventy-three chagasic had megas. Megacolon was the most frequent, followed by megaesophagus. Megacolon associated with megaesophagus was the third most common finding. Our data are discussed and compared with the literature. Megacolon and megaesophagus were more prevalent in man, as shown by other workers. Higher parasitemia perhaps could explain this finding.
Subject(s)
Chagas Disease/complications , Esophageal Achalasia/etiology , Megacolon/etiology , Adult , Autopsy , Brazil/epidemiology , Cross-Sectional Studies , Esophageal Achalasia/epidemiology , Female , Humans , Male , Megacolon/epidemiology , Middle AgedABSTRACT
This is a review of 4.690 necropsies and 24.209 surgical pathology specimens describing the association between megacolon chagasic and malignant tumors of the large bowel. The prevalence of malignant tumors of the large bowel was not higher in megacolon.
