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Nucleosides Nucleotides Nucleic Acids ; 29(3): 168-77, 2010 Mar.
Article in English | MEDLINE | ID: mdl-20408048

ABSTRACT

This article describes a synthetic route to generate two purine-pyrimidine and pyrimidine heterodinucleosides. Both microwave activated regioselective alkylation using hydride and copper-catalyzed-azide-alkyne-cycloaddition (CuAAC) were used in order to perform the synthesis.


Subject(s)
Oligonucleotides/chemistry , Oligonucleotides/chemical synthesis , Purines/chemistry , Pyrimidines/chemistry , Triazoles/chemistry , Catalysis , Copper/chemistry , Cyclization , Nucleic Acid Conformation
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