ABSTRACT
PURPOSE: Optimal timing of neck dissection remains debated in the conservative management of patients with locoregionally advanced squamous cell carcinoma of the head and neck. PATIENTS AND METHODS: The files of 63 patients with radiographic evidence of bulky or necrotic nodal metastases treated by up-front neck dissection and definitive radiotherapy between 2000 and 2012 at two institutions were retrospectively reviewed. RESULTS: The primary site was oropharyngeal, hypopharyngeal or laryngeal in 63%, 21% and 13% cases, respectively. Overall, 83% of the tumours were staged pN2b or more. Extracapsular spread was found in 48 cases (77%). After a 48-month median follow-up, the 3-year locoregional control and overall survival were 88% and 68%, respectively. Only one isolated failure occurred in the dissected neck. CONCLUSION: This combination therapy provides a good locoregional tumour control. It should be considered as an option in laryngeal, hypopharyngeal or oropharyngeal squamous cell carcinomas with bulky or necrotic nodal metastases at presentation.
Subject(s)
Carcinoma, Squamous Cell/therapy , Head and Neck Neoplasms/therapy , Neck Dissection , Neoadjuvant Therapy , Adult , Aged , Carcinoma, Squamous Cell/mortality , Carcinoma, Squamous Cell/pathology , Chemotherapy, Adjuvant , Dose Fractionation, Radiation , Female , Follow-Up Studies , Head and Neck Neoplasms/mortality , Head and Neck Neoplasms/pathology , Humans , Lymphatic Metastasis , Male , Middle Aged , Radiotherapy, Adjuvant , Retrospective StudiesABSTRACT
PURPOSE: Clip migration occurs frequently in clinical practice (13-20%), irrespective of the approach. The purpose of this article is to suggest tricks in order to decrease clip migration and optimize presurgical localization. MATERIALS AND METHODS: Retrospective study of breast macrobiopsy from a lateral approach performed between March 2003 and June 2004: 447 clips were placed. Sixty clips showed migration>20 mm, due to the accordion effect in 59 cases (98.4%). These 59 procedures were analyzed to try and understand the underlying mechanisms of clip migration. RESULTS: From these 59 clips, more migrations were noted on CC compression (16.6%) compared to MLO compression (5.2%). This difference was statistically significant. Therefore, we promote the use of MLO compression. This incidence also allows optimal presurgical localization in case of clip migration, by placing the patient in the same position while modulating depth based on the extent of clip displacement. CONCLUSION: For quality purposes, it is imperative to know the clip position relative to the initial target. By using MLO compression from a lateral approach, it is possible to reduce clip migration and optimize future presurgical localization.
Subject(s)
Biopsy/instrumentation , Biopsy/methods , Breast/pathology , Foreign-Body Migration , Radiology, Interventional , Stereotaxic Techniques , Surgical Instruments , Adult , Aged , Aged, 80 and over , Breast/surgery , Chi-Square Distribution , Female , Humans , Mammography , Middle AgedABSTRACT
The role of MRI for presurgical local staging of breast cancers amenable to conservative treatment has been the subject of multiple publications and tends to become a "validated" indication in routine practice. The purpose of the paper is to review the advantages and limitations of this imaging modality that is part of a comprehensive management that must be validated by clinical data especially with regards to local recurrence and survival. Knowledge of these elements combined with more precise indications should result in improved patient management while avoiding overtreatment or unnecessary anxiety-producing examinations.
Subject(s)
Breast Neoplasms/diagnosis , Magnetic Resonance Imaging , Mammography , Ultrasonography, Mammary , Female , Humans , Preoperative CareABSTRACT
State-of-the-art analysis of non invasive diagnostic imaging techniques to demonstrate upper urinary tract obstruction. Advances in imaging techniques are illustrated (sonography, CT scan, MRI). The imaging features of different presentations of chronic and intermittent obstruction are described with reference to current imaging modalities. New strategies for evaluation of chronic and intermittent upper urinary tract obstruction are proposed using ultrasonography as the first line examination. The role of MRI is illustrated. Causes of obstruction are classified based from the intraluminal, parietal or extrinsic location of the lesion.
