European isolation and confinement study. Lower body negative pressure tests.

From the LBNP experiment carried out during the ISEMSI project, we can conclude that there was no indication of the cardiac deconditioning syndrome in any of the six subjects. The absence of such effects can probably be ascribed to the following two conditions: (1) the subjects were not in inactive conditions; and (2) there was only a slight overpressure in the hyperbaric chamber.

Lower body negative pressure as a countermeasure against orthostatic intolerance for long term space flight.

NASA: The effectiveness of lower body negative pressure (LBNP) as a countermeasure against orthostatic intolerance associated with bed rest was investigated. Subjects were exposed to antiorthostatic bedrest at 6 degrees head down tilt, with some exposed to LBNP and some exposed to LBNP with exercise during the bedrest period. Tilt table tests were then performed on all subjects, with heart rate and blood pressure measurements taken. Exposure to LBNP seemed effective in preventing syncope in subjects exposed to bedrest. These results are discussed.^ieng