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Nucleic Acids Symp Ser (Oxf) ; (52): 155-6, 2008.
Article in English | MEDLINE | ID: mdl-18776300

ABSTRACT

A series of red emitting vinyl-triphenyamines (TP) have been synthesized and evaluated for their two photon absorption (2PA) properties. These compounds are virtually non fluorescent in the free state but exhibit a bright red fluorescence upon binding to double-stranded DNA, both in one- and two-photon absorption. This feature allows one- and two-photon confocal imaging in cells of nuclear DNA with an excellent contrast. Derivatizable analogues for covalent bioconjugation to oligonucleotides are described and variation on the structure is discussed.


Subject(s)
Aniline Compounds/chemistry , DNA/analysis , Fluorescent Dyes/chemistry , Pyridinium Compounds/chemistry , Animals , CHO Cells , Cricetinae , Cricetulus , Microscopy, Confocal , Photons
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