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Allergy ; 71(2): 272-4, 2016 Feb.
Article in English | MEDLINE | ID: mdl-26443126

ABSTRACT

It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 µg induced oral allergy syndromes in 26.4%, 3.2 µg in 15.3%, 6.3 µg in 27.8%, 12.5 µg in 8.3%, 25 µg in 11.1%, and 50 µg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 µg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy.


Subject(s)
Allergens/immunology , Antigens, Plant/immunology , Betula/adverse effects , Food Hypersensitivity/diagnosis , Food Hypersensitivity/immunology , Malus/adverse effects , Plant Proteins/immunology , Pollen/immunology , Rhinitis, Allergic, Seasonal/immunology , Administration, Sublingual , Adult , Allergens/administration & dosage , Female , Food Hypersensitivity/complications , Humans , Male , Middle Aged , Rhinitis, Allergic, Seasonal/complications , Young Adult
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