[Local arterial hypertension in the pathogenesis of chronic pancreatitis].

Based on the rheographic studies of the postprandial transformation of the splanchnic blood flow and morphological study of the resected parts of the pancreas in patients with chronic fibrosing pancreatitis, the authors revealed functional and morphological attributes of local arterial hypertension and, at the stage of exacerbation of disease--manifestations of a vascular crisis. Local arterial hypertension with vascular crises originating on its basis is an important pathogenetic factor of the progression of chronic pancreatitis. It is assumed that local arterial hypertension develops against the background of depression of cholinergic effects and domination of sympathetic effects.

Morphological analysis of the effect of richlocaine on gingival mucosa during exacerbation of chronic periodontitis.

We studied morphology of the regeneratory process in gingival tissues during treatment of exacerbation of chronic generalized periodontitis. Richlocaine treatment led to more pronounced activation of neoangiogenesis in inflammatory cellular infiltrate in comparison with traditional drug treatment. Richlocaine stimulated vascularization of regenerating tissues, promoted more extensive normalization of the structure of the gingival mucosa, and prevented the development of fibrosclerotic changes.

Morphological study of reparative processes in the gingiva during therapy of chronic periodontitis with energostim and application of orthopedic splinting constructions.

We studied morphological characteristics of the regenerative process in gingival tissues during therapy of chronic periodontitis. Energostim stimulated macrophageal reaction and promoted neoangiogenesis in the inflammatory infiltrate. It was not observed after traditional drug therapy. Energostim promoted vascularization in regenerating tissues, normalized the structure at a greater area of the lamina propria of the gingiva, and prevented fibrous and sclerotic changes. The volume of histiolymphocytic infiltrates in regenerating gingival tissues decreased after application of intradental splints.

[Morphofunctional characteristics of arterial bed in exacerbation of gastroduodenal ulcer disease and chronic pancreatitis]. / Morfofunktsional'naia kharakteristika arterial'nogo rusla pri obostrenii iazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki i khronicheskogo pankreatita.

Samples of the stomach, duodenum and pancreas removed from 76 patients obtained during organ-preserving operations for ulcer and chronic pancreatitis were examined morphologically. It is found that the most frequent type of changes in the intraorgan arteries is their wall hypertrophy in combination with hyperelastosis and elastotic fibrosis. This characterizes chronic local arterial hypertension. An additional morphological symptom complex caused by a vegetative vascular crisis is formed in the arteries of the damaged organ in exacerbation of the disease. The complex includes prominent dystonic and alterative changes of small arteries leading to stasis and thrombogenesis in the microvessels. Unknown so far phenomenon of arterial invagination in 18 patients was observed. It leads to a complete block of circulation, acute ischemia followed by tissue necrosis which was most typical for ulcer exacerbation and chronic pancreatitis.

[Local arterial hypertension in the pathogenesis of ulcers and chronic pancreatitis]. / Lokal'naia arterial'naia gipertenziia v patogeneze iazvennoi bolezni i khronicheskogo pankreatita.

Local arterial hypertension is a morphological and functional phenomenon representing a change of the arterial channel, which is observed in a restricted part of an organ being as large as the blood supply pool of a large artery, or the pool of a separate artery. No demonstrative explanation has been found for these vascular channel changes similar to the widespread ones that are observed in case of systemic hypertension until now.

[Pathomorphology of regenerative processes in mandibular fracture after sodium succinate treatment and laser magnetotherapy in an experimental setting]. / Morfologicheskií analiz reparativnykh protsessov v éksperimente pri sazhivlenii perelomov nizhnei cheliusti v usloviiakh primeneniia suktsinata natriia i lazeromagnitoterapii.

Morphological reactions in tissue adjacent to mandibular angular fracture were studied in guinea pigs treated with sodium succinate and laser magnetotherapy. Due to succinate therapy the exudative component of inflammation was less expressed in comparison with the control, macrophagal reaction and neoangiogenesis were activated, the volume of damaged muscle tissue and the incidence of suppurations decreased. The number of osteoblasts increased and new bone structures acquired a lamellar pattern earlier than in the control. Sodium succinate therapy in combination with laser magnetotherapy had a more pronounced positive effect as regards activation of macrophagal reaction and neoangiogenesis and a decrease in the area of fibrosclerotic changes in the zone of damaged muscles, where newly formed myosymplasts differentiated into myotubes and even in muscle fibers. Suppuration of the wound was prevented. Bone tissue in the fracture zone formed without preliminary formation of cartilaginous tissue, which resulted in more rapid osteogenesis (lamellar bone growth in the fracture zone).

[Differential diagnostic and prognostic criteria of precancerous processes and cancer of the large intestine]. / Differentsial'no-diagnosticheskie i prognosticheskie kriterii predrakovykh protsessov i raka tolstoi kishki.

Colon epithelial tumours from 682 patients have been analyzed. The incidence of the background processes in the mucous membrane adjacent to the tumour is established as a function of tumour progression. Transition of the mucus formation to the sialomucin synthesis in the transitional mucous membrane was observed in 1/3 of the cases. Of prognostic value for the 5-year survival were such indices as a stage of the disease according to Guttman and Dukes, tumour macroscopy, the state of regional lymph nodes and the degree of carcinoma differentiation. The data on the content of the immunocompetent cells, tissue basophils and their degranulation, eosinophils, lymphocyte plasmatization, depending on the stage of the disease are also presented.

[New dyes containing gallocyanine for staining histological sections]. / Novye krasiteli, soderzhashchie gallotsianin, dlia okraski gistologicheskikh srezov.

The methods of histological slides staining with dyes containing gallocyanin are proposed.

[Early morphologic changes in the myocardium after a wound of the heart complicated by hemopericardium (experimental study)]. / Rannie morfologicheskie izmeneniia miokarda posle raneniia serdtsa, oslozhnennogo gemoperikardom (éksperimental'noe issledovanie).

The myocardia of 20 dogs with penetrating injuries of the right ventricles were studied morphologically and histochemically. Microcirculatory disorders found in the myocardium included overfilled venous and capillary bed that eventually led to capillary stasis, interstitial edema, hemorrhagic foci, arteriolosclerosis. For the first time focal disseminated injuries of cardiomyocytes of a segmental, zonal, and contractural type were detected. In line with these lesions, earlier cardiomyocytic changes were found, such as margination of nuclear chromatin, clarification of karyoplasm, interfibrillar edema of sarcoplasm with subsequent loosening and aggregation of myofibrils. This complex of morphologic changes was invariably found in the myocardia of both ventricles in the dogs dead 10-90 minutes after cardiac injury.

[Pathomorphology of endocrine glands during the latent period of experimental intestinal carcinogenesis]. / Patomorfologiia éndokrinnykh zhelez v latentnom periode éksperimental'nogo kantserogeneza kishechnika.

Pathomorphology of endocrine glands in 62 rats in the latent period of intestinal carcinogenesis caused by 1,2-dimethyl hydrazine was studied. The morphological picture of the latent period includes atrophic changes of the adrenal cortex and the thyroid gland, A- and B-cells of pancreatic insulae and interstitial Leidig cells, as well as severer dystrophic changes of thyreotrophs, thymus epithelium, spermatogenic epithelium, and granuloses of growing follicles. These changes are combined with hypertrophy of follicle-stimulating gonadotrophs, hyperplasia of the body-tissue in the ovaries, as well as accumulation of neurosecretory substance in neurons of paraventricular and supraoptic nuclei of hypothalamus, neurosecretory pathways, and neurohypophysis. No morphological changes were found in the latent period in hypophysis acidophilic cells, lymphoid elements of the thymus, primordial follicles and cells of parathyroid glands.

[Morphological study of the neurosecretory hypothalamo-hypophyseal system and thyroid gland in intestinal carcinogenesis]. / Morfologicheskoe issledovanie meirosekretornoi gipotalamo-gipofizarnoi sistemy i shchitovidnoi zhelezy pri kantserogeneze kishechnika.

Pathomorphology of the neurosecretory hypothalamo-hypophyseal system and the thyroid gland of 150 rats of both sexes was investigated in intestinal carcinogenesis induced by 1.2-dimethyl hydrazine. Inhibition of the neurosecretory activity of paraventricular and supraoptical nuclei as well as atrophic changes in th: thyroid gland were found to be associated with the latent period of carcinogenesis. The arising of the intestinal tumor is accompanied by hypertrophy of neurons and their nuclei, by a decrease in the neurosecretory substance content and the thyroid gland tendency to return to normal. The tumor spreading provoked neuron hypertrophy and the reduction of the neurosecretory substance as well and pronounced atrophic changes in the thyroid gland.

[Adrenal cortex in experimental carcinogenesis of the intestine]. / Kora nadpochechnikov pri éksperimental'nom kantserogeneze kishechnika.

Morphological and histochemical examinations of the adrenal cortex of 150 rats with intestinal carcinogenesis caused by 1,2-dimethylhydrasine, and comparison of the results with control results in 20 intact rats showed the latent period to occur against the background of atrophic changes in the cortical matter consisting in a decrease in the adrenal weight, narrowing of the cortical matter, decreasing diameter of the secretory cells nuclei, accumulation of lipids and cholesterol in zona fasciculata and zona reticulosa, and decreased content of ascorbic acid. In contrast, the period of tumour growth within the intestinal mucosa coincides with hypertrophic changes in the adrenal cortex. In extensive cancer, the intensity of these hypertrophic changes increased, and dystrophically changed cells and micronecroses appeared.

[Ovarian morphology during experimental blastomogenesis in the cerebellum]. / Morfologiia iaichnikov pri éksperimental'nom blastomogeneze v mozzhechke.

A morphological and histochemical study of the ovaries in 79 rats with cerebellar blastomogenesis due to DMBA in comparison with the ovaries of intact rats, rats with trauma of the cerebellum, rats with a paraffin pill implanted into the cerebellum, as well as with the ovaries of rats with a chemical cancerogenesis of the intestine, permitted to claim, that the most characteristic changes of the ovaries in cerebellar blastomogenesis consist in reduced amount of premordial follicules, athresia of the growing follicles and a formation of multiple follicular cysts. These processes are underlain by destruction of premordial follicles and a degeneration of the ovule in the growing follicles.