ABSTRACT
A controlled study of therapeutic end-to-side portacaval shunt was carried out from 1968 to 1971 in 89 patients with alcoholic cirrhosis. Recurrent gastrointestinal bleeding was less common and chronic hepatic encephalopathy was more common in patients with shunts than in patients without shunts. The survival-rate was lower, but not significantly, in patients with shunts. No overall benefit of the operation could be demonstrated in cirrhotic patients with the selection criteria and the type of surgical shunt used in this study.
Subject(s)
Liver Cirrhosis, Alcoholic/surgery , Portacaval Shunt, Surgical , Adult , Aged , Evaluation Studies as Topic , Female , Follow-Up Studies , Gastrointestinal Hemorrhage/epidemiology , Gastrointestinal Hemorrhage/etiology , Hepatic Encephalopathy/epidemiology , Hepatic Encephalopathy/etiology , Humans , Liver Cirrhosis, Alcoholic/complications , Liver Cirrhosis, Alcoholic/mortality , Male , Middle Aged , Postoperative Complications/epidemiology , Postoperative Complications/etiology , RecurrenceSubject(s)
Gastrointestinal Hemorrhage/surgery , Liver Cirrhosis/surgery , Portacaval Shunt, Surgical/mortality , Acute Disease , Adult , Aged , Alcoholism/complications , Chronic Disease , Emergencies , Female , Gastrointestinal Hemorrhage/complications , Gastrointestinal Hemorrhage/mortality , Gastroscopy/mortality , Hepatic Encephalopathy/etiology , Hepatic Encephalopathy/mortality , Humans , Liver Cirrhosis/complications , Liver Cirrhosis/mortality , Male , Middle Aged , PrognosisSubject(s)
Ascites/blood , Erythrocytes/metabolism , Liver Cirrhosis/blood , Plasma/metabolism , Potassium/metabolism , Ascites/etiology , Female , Humans , In Vitro Techniques , Liver Cirrhosis/complications , Liver Cirrhosis/metabolism , Male , Potassium Isotopes , Sodium/blood , Time Factors , Water-Electrolyte BalanceSubject(s)
Hepatitis A , Adolescent , Adult , Age Factors , Aged , Brain Diseases/etiology , Child, Preschool , Female , Hepatitis A/complications , Hepatitis A/mortality , Humans , Liver Function Tests , Male , Middle Aged , PrognosisSubject(s)
Exchange Transfusion, Whole Blood , Hepatic Encephalopathy/therapy , Adolescent , Adult , Female , Hepatitis/therapy , Humans , Liver Function Tests , Male , Middle Aged , PrognosisSubject(s)
Bile/analysis , Sulfobromophthalein/metabolism , Animals , Bile/metabolism , Dehydrocholic Acid , Male , Rats , Sodium , Sulfobromophthalein/administration & dosageSubject(s)
Liver Cirrhosis/pathology , Liver/pathology , Alcoholism/complications , Alcoholism/pathology , Animals , Clinical Trials as Topic , Endoplasmic Reticulum , Hepatomegaly/pathology , Humans , Liver Cirrhosis/diagnosis , Liver Cirrhosis, Experimental/pathology , Microscopy, Electron , Mitochondria, Liver , RatsSubject(s)
Alcoholic Intoxication/complications , Carbohydrate Metabolism , Liver/analysis , Liver/enzymology , Animals , Body Weight , Ethanol/metabolism , Glucose-6-Phosphatase/metabolism , Glucosyltransferases/metabolism , Glycogen Storage Disease/drug therapy , Glycolysis/drug effects , Hepatectomy , Humans , Hypoglycemia/etiology , Liver Glycogen/analysis , Liver Glycogen/metabolism , Liver Regeneration/drug effects , Proteins/analysis , Rats , Sucrose/administration & dosageABSTRACT
The authors have studied the influence of rose bengal, and, by comparison, of uranin, on choleresis in the rabbit. Uranin induced an increase in bile flow and a decrease in bile salt concentration in bile. These results are consistent with an osmotic mechanism, as proposed by Sperber (1959). By contrast, rose bengal induced a marked decrease in bile flow and an increase in bile salt concentration. In rose bengal-treated animals (30 mumoles per kilogram body weight intravenously), bile flow was 65% lower and bile salt concentration 95% higher than in control animals studied during the same periods. The relationship between bile flow and bile salt excretion is consistent in the rabbit, with the existence of a bile salt-independent secretion of 60 mg per minute per kilogram body weight, that is, 60% of bile flow. In rose bengal-treated animals, this fraction was only 15 mg per minute per kilogram body weight. It is concluded that rose bengal inhibits the bile salt-independent fraction. Rose bengal, as other phtalein dyes, is excreted by the liver cells. Its effect on the bile salt-independent fraction suggests that this fraction is secreted by the hepatocytes.
