ABSTRACT
A parenteral penicillin model of epilepsy in the rat was investigated with the aim of evaluating its reliability. Behavioral and EEG patterns were strongly variable in a group of 100 rats injected with 1,000,000 IU/kg of penicillin i.p. Gross counts of spikes were Fourier transformed and grouped into two time windows in 24 out of the 100 rats. Analysis of variance applied to compare the two time windows showed a sufficient suitability of the phenomenon for antiepileptic drug testing purposes. Five subsequent injections of penicillin performed in 8 rats showed that a spontaneous decrease of the response takes place, preventing a crossover design in pharmacological analyses. Evans Blue studies demonstrated that there was not a breakdown of the blood-brain barrier; this model can be used for testing anticonvulsants unable to penetrate the blood-brain barrier.
Subject(s)
Disease Models, Animal , Epilepsy/chemically induced , Penicillins , Animals , Blood-Brain Barrier , Electroencephalography , Injections, Intraperitoneal , Male , Rats , Rats, Inbred StrainsABSTRACT
The effect of a suspension of GABA and phosphatidylserine (PS), phosphatidylcholine, or phosphatidylethanolamine was studied on penicillin-induced epileptic activity in rats. GABA-PS significantly reduced the number of spikes, in comparison with either the other phospholipid compounds or normal saline. No effect was observed after GABA or PS administration alone. We suggest that the different effects probably depend on extracellular and intracellular factors.
Subject(s)
Action Potentials/drug effects , Phospholipids/pharmacology , Seizures/chemically induced , gamma-Aminobutyric Acid/pharmacology , Animals , Brain/drug effects , Male , Penicillins , Phosphatidylcholines/pharmacology , Phosphatidylethanolamines/pharmacology , Phosphatidylserines/pharmacology , Rats , Rats, Inbred StrainsSubject(s)
Maxilla/surgery , Periodontal Pocket/surgery , Periodontitis/surgery , Dental Caries/therapy , Humans , Surgical FlapsABSTRACT
The authors report 11 cases of Tolosa-Hunt syndrome, a painful ophthalmoplegia due to an aspecific, benign, steroid-responsive inflammation of the cavernous sinus. Other causes of painful ophthalmoplegia, diagnostic findings and etiological hypothesis are discussed.
Subject(s)
Ophthalmoplegia/diagnosis , Adult , Aged , Female , Humans , Male , Middle Aged , Ophthalmoplegia/drug therapy , Ophthalmoplegia/etiology , SyndromeABSTRACT
The authors evaluated hematological side effects in 410 epileptic patients under chronic therapy. The aim of the study was to find out the most suitable parametres for preliminary screening. Values outside the normal range were seen in patients treated with multiple drug therapy and in patients receiving antiepileptic drugs from 3 years at least. The following tests were the most frequently influenced: GOT, GPT, alcaline phosphatase, protrombin time, fibrinogen.
