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1.
S Afr Med J ; 114(3): e1531, 2024 Mar 20.
Article in English | MEDLINE | ID: mdl-38525576

ABSTRACT

Maternal healthcare in South Africa faces huge private and public health systems challenges. A key challenge for policy makers is how to address the inappropriate patterns of obstetric care in the private sector and how to mobilise private sector resources to serve the broader population dependent on the public sector, without replicating those patterns of inappropriate care. Developing and implementing new obstetric care models that address these challenges and lend themselves to public private engagements could play a vital role in efforts to improve obstetric care in the country. Drawing on insights from research we carried out on the care and contracting models used by five rural district hospitals in the Western Cape Province to contract private general practitioners to provide caesarean delivery services, this article outlines a potential alternative private sector obstetric care model with the aim of stimulating discussion by all relevant stakeholders on the development of new obstetric models for improving obstetric care in the country.


Subject(s)
Delivery of Health Care , General Practitioners , Pregnancy , Female , Humans , South Africa
2.
S Afr Med J ; 113(12): 24, 2023 Dec 04.
Article in English | MEDLINE | ID: mdl-38525626

ABSTRACT

Postpartum haemorrhage is the leading cause of preventable maternal mortality in South Africa. In a significant breakthrough in the management of PPH, the E-MOTIVE trial found that a multifaceted health service intervention reduced severe PPH after vaginal delivery by 60% in 78 hospitals in Nigeria, Kenya, Tanzania and SA. The E-MOTIVE approach comprises objective blood loss measurement monitored every 15 minutes during the first hour after delivery to detect PPH early and trigger a bundle of first-line treatments, including massaging the uterus, oxytocin infusion, tranexamic acid infusion, intravenous crystalloid fluids, examination for the cause, emptying the bladder and, if necessary, escalation of care. E-MOTIVE was integrated into the existing Essential Steps in Managing Obstetric Emergencies algorithm. Certain research-related elements of the trial setting cannot be replicated in routine practice. Therefore, we need to develop local strategies to ensure the essential clinical elements of the intervention are implemented. Potential strategies include incorporating the E-MOTIVE principles into national guidelines, ongoing training strategies and ensuring all facilities are equipped with necessary medication, equipment and delegations. This breakthrough intervention provides hope for women in SA, and requires a purposeful, co-ordinated implementation strategy on a national scale to reach all levels of the health service.


Subject(s)
Oxytocics , Postpartum Hemorrhage , Female , Humans , Pregnancy , Delivery, Obstetric , Oxytocics/therapeutic use , Oxytocin/therapeutic use , Postpartum Hemorrhage/diagnosis , Postpartum Hemorrhage/therapy , South Africa , Clinical Trials as Topic
3.
BJOG ; 2022 Apr 11.
Article in English | MEDLINE | ID: mdl-35411672

ABSTRACT

AIMS: To develop algorithms for identifying, managing and monitoring postpartum haemorrhage (PPH) and other third stage of labour abnormalities after vaginal delivery. POPULATION: Women with low-risk singleton term pregnancies who have had a vaginal delivery. SETTING: Hospital settings with a particular focus on healthcare facilities in low- and middle-income countries (LMICs). SEARCH STRATEGY: Searches for international and national guidance documents, research databases (Cochrane, Medline and CINAHL) and published systematic reviews. Searches were limited to work published in English between 1 January 2008 and 31 December 2018. CASE SCENARIOS: Four interlinked case scenarios were identified for algorithm development: (1) an approach to PPH after vaginal delivery, (2) uterine atony, (3) genital tract trauma and (4) retained placenta/placental products. CONCLUSIONS: The development of clear approaches to the assessment, resuscitation, treatment and monitoring of the four case scenarios are presented as algorithms, based on available evidence. They need to be field tested and evaluated for effectiveness, and may be adapted for electronic decision support tools using artificial intelligence in different settings. Further research is needed around multimodal sequential packages of care for PPH, conservative surgical measures, resuscitation in LMICs, and how a respectful maternity care focus can be incorporated into the algorithms. TWEETABLE ABSTRACT: Algorithm development for standardised approaches to managing PPH in low-resource settings.

4.
BJOG ; 2022 Apr 11.
Article in English | MEDLINE | ID: mdl-35411684

ABSTRACT

AIM: To describe standardised iterative methods used by a multidisciplinary group to develop evidence-based clinical intrapartum care algorithms for the management of uneventful and complicated labours. POPULATION: Singleton, term pregnancies considered to be at low risk of developing complications at admission to the birthing facility. SETTING: Health facilities in low- and middle-income countries. SEARCH STRATEGY: Literature reviews were conducted to identify standardised methods for algorithm development and examples from other fields, and evidence and guidelines for intrapartum care. Searches for different algorithm topics were last updated between January and October 2020 and included a combination of terms such as 'labour', 'intrapartum', 'algorithms' and specific topic terms, using Cochrane Library and MEDLINE/PubMED, CINAHL, National Guidelines Clearinghouse and Google. CASE SCENARIOS: Nine algorithm topics were identified for monitoring and management of uncomplicated labour and childbirth, identification and management of abnormalities of fetal heart rate, liquor, uterine contractions, labour progress, maternal pulse and blood pressure, temperature, urine and complicated third stage of labour. Each topic included between two and four case scenarios covering most common deviations, severity of related complications or critical clinical outcomes. CONCLUSIONS: Intrapartum care algorithms provide a framework for monitoring women, and identifying and managing complications during labour and childbirth. These algorithms will support implementation of WHO recommendations and facilitate the development by stakeholders of evidence-based, up to date, paper-based or digital reminders and decision-support tools. The algorithms need to be field tested and may need to be adapted to specific contexts. TWEETABLE ABSTRACT: Evidence-based intrapartum care clinical algorithms for a safe and positive childbirth experience.

5.
S Afr Med J ; 110(8): 747-750, 2020 Jul 29.
Article in English | MEDLINE | ID: mdl-32880299

ABSTRACT

Broader policy research and debate on the issues related to the planning of National Health Insurance (NHI) in South Africa (SA) need to be complemented by case studies to examine and understand the issues that will have to be dealt with at micro and macro levels. The objective of this article is to use caesarean section (CS) as a case study to examine the health systems challenges that NHI would need to address in order to ensure sustainability. The specific objectives are to: (i) provide an overview of the key clinical considerations related to CS; (ii) assess the CS rates in the SA public and private sectors; and (iii) use a health systems framework to examine the drivers of the differences between the public and private sectors and to identify the challenges that the proposed NHI would need to address on the road to implementation.


Subject(s)
Cesarean Section/statistics & numerical data , National Health Programs , Female , Health Planning , Humans , Pregnancy , Private Sector/statistics & numerical data , Public Sector/statistics & numerical data , South Africa
6.
S Afr Med J ; 108(3): 171-175, 2018 Feb 27.
Article in English | MEDLINE | ID: mdl-30004358

ABSTRACT

BACKGROUND: A maternal near-miss is defined as a life-threatening pregnancy-related complication where the woman survives. The World Health Organization (WHO) has produced a tool for identifying near-misses according to criteria that include the occurrence of a severe maternal complication together with organ dysfunction and/or specified critical interventions. Maternal deaths have been audited in the public sector Metro West maternity service in Cape Town, South Africa, for many years, but there has been no monitoring of near-misses. OBJECTIVES: To measure the near-miss ratio (NMR), maternal mortality ratio (MMR) and mortality index (MI), and to investigate the near-miss cases. METHODS: A retrospective observational study conducted during 6 months in 2014 identified and analysed all near-miss cases and maternal deaths in Metro West, using the WHO criteria. RESULTS: From a total of 19 222 live births, 112 near-misses and 13 maternal deaths were identified. The MMR was 67.6 per 100 000 live births and the NMR 5.83 per 1 000 live births. The maternal near-miss/maternal death ratio was 8.6:1 and the MI 10.4%. The major causes of near-miss were hypertension (n=50, 44.6%), haemorrhage (n=38, 33.9%) and puerperal sepsis (n=13, 11.6%). The first two conditions both had very low MIs (1.9% and 0%, respectively), whereas the figure for puerperal sepsis was 18.9%. Less common near-miss causes were medical/surgical conditions (n=7, 6.3%), non-pregnancy-related infections (n=2, 1.8%) and acute collapse (n=2, 1.8%), with higher MIs (33.3%, 66.7% and 33.3%, respectively). Critical interventions included massive blood transfusion (34.8%), ventilation (40.2%) and hysterectomy (30.4%). Considering health system factors, 63 near-misses (56.3%) initially occurred at a primary care facility, and the patients were all referred to the tertiary hospital; 38 (33.9%) occurred at a secondary hospital, and 11 (9.8%) at the tertiary hospital. Analysis of avoidable factors identified lack of antenatal clinic attendance (11.6%), inter-facility transport problems (6.3%) and health provider-related factors (25.9% at the primary level of care, 38.2% at secondary level and 7.1% at tertiary level). CONCLUSIONS: The NMR and MMR for Metro West were lower than in other developing countries, but higher than in high-income countries. The MI was low for direct obstetric conditions (hypertension, haemorrhage and puerperal sepsis), reflecting good quality of care and referral mechanisms for these conditions. The MIs for non-pregnancy-related infections, medical/surgical conditions and acute collapse were higher, suggesting that medical problems need more focused attention.


Subject(s)
Maternal Death/statistics & numerical data , Near Miss, Healthcare/statistics & numerical data , Adolescent , Adult , Blood Transfusion/statistics & numerical data , Female , Humans , Hypertension/epidemiology , Hysterectomy/statistics & numerical data , Live Birth , Patient Transfer , Postpartum Hemorrhage/epidemiology , Pregnancy , Pregnancy Complications/epidemiology , Prenatal Care/statistics & numerical data , Respiration, Artificial/statistics & numerical data , Retrospective Studies , Sepsis/epidemiology , South Africa/epidemiology , Young Adult
7.
S Afr Med J ; 107(7): 606-610, 2017 Jun 30.
Article in English | MEDLINE | ID: mdl-29025451

ABSTRACT

BACKGROUND: Nutrition in pregnancy has implications for both mother and fetus, hence the importance of an accurate assessment at the booking visit during antenatal care. The body mass index (BMI, kg/m2) is currently the gold standard for measuring body fatness. However, pregnancy-associated weight gain and oedema, as well as late booking in our population setting, cause concern about the reliability of using the BMI to assess body fat or nutritional status in pregnancy. The mid-upper arm circumference (MUAC) has been used for many decades to assess malnutrition in children aged <5 years. Several studies have also shown a strong correlation between MUAC and BMI in both pregnant and non-pregnant adult populations. OBJECTIVE: To assess the correlation between the MUAC and BMI in pregnant women booking for antenatal care in the Metro West area of Cape Town, South Africa. METHODS: We conducted a cross-sectional study of women booking at four midwife obstetric units. Anthropometric measurements (height, weight and MUAC) were carried out on pregnant women at their first antenatal booking visit. RESULTS: The results showed a strong correlation between MUAC and BMI in pregnant women up to 30 weeks' gestation. The correlation was calculated at 0.92 for the entire group. The MUAC cut-offs for obesity (BMI >30) and malnutrition (BMI <18.5) were calculated as 30.57 cm and 22.8 cm, respectively. CONCLUSION: MUAC correlates strongly with BMI in pregnancy up to a gestation of 30 weeks in women attending Metro West maternity services. In low-resource settings, the simpler MUAC measurement could reliably be substituted for BMI to assess nutritional status.

8.
S Afr Med J ; 106(5): 53-7, 2016 Apr 07.
Article in English | MEDLINE | ID: mdl-27138666

ABSTRACT

Maternal deaths associated with caesarean deliveries (CDs) have been increasing in South Africa over the past decade. The objective of this report is to bring national attention to this increasing epidemic of maternal deaths due to bleeding associated with CD in the majority of provinces of the country. Individual chart reviews of women who died from bleeding at or after CD show that 71% had avoidable factors. Among the steps we can take are to improve surgical skills and experience, especially in rural hospitals, to improve clinical observations in the immediate postoperative period and in the postnatal wards, and to ensure that appropriate oxytocic agents are given to prevent postpartum haemorrhage. CEOs and medical managers of health facilities, district clinical specialists, heads of obstetrics and gynaecology, and midwifery training institutions must show leadership and accountability in providing an appropriate environment to ensure that women who require CD receive the procedure for the correct indications and in a safe manner to minimise risks.


Subject(s)
Cesarean Section/adverse effects , Maternal Mortality , Postoperative Hemorrhage/mortality , Clinical Competence , Female , Hospitals, Rural/standards , Humans , Maternal Mortality/trends , Monitoring, Physiologic , Oxytocics/therapeutic use , Postoperative Hemorrhage/prevention & control , Pregnancy , South Africa/epidemiology
9.
Pregnancy Hypertens ; 5(4): 273-9, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26597740

ABSTRACT

BACKGROUND: Epidemiological findings suggest that the link between poverty and pre-eclampsia might be dietary calcium deficiency. Calcium supplementation has been associated with a modest reduction in pre-eclampsia, and also in blood pressure (BP). METHODS: This exploratory sub-study of the WHO Calcium and Pre-eclampsia (CAP) trial aims to determine the effect of 500mg/day elemental calcium on the blood pressure of non-pregnant women with previous pre-eclampsia. Non-pregnant women with at least one subsequent follow-up trial visit at approximately 12 or 24weeks after randomization were included. RESULTS: Of 836 women randomized by 9 September 2014, 1st visit data were available in 367 women of whom 217 had previously had severe pre-eclampsia, 2nd visit data were available in 201 women. There was an overall trend to reduced BP in the calcium supplementation group (1-2.5mmHg) although differences were small and not statistically significant. In the subgroup with previous severe pre-eclampsia, the mean diastolic BP change in the calcium group (-2.6mmHg) was statistically larger than in the placebo group (+0.8mmHg), (mean difference -3.4, 95% CI -0.4 to -6.4; p=0.025). The effect of calcium on diastolic BP at 12weeks was greater than in those with non-severe pre-eclampsia (p=0.020, ANOVA analysis). CONCLUSIONS: There is an overall trend to reduced BP but only statistically significant in the diastolic BP of women with previous severe pre-eclampsia. This is consistent with our hypothesis that this group is more sensitive to calcium supplementation, however results need to be interpreted with caution.


Subject(s)
Blood Pressure Determination , Blood Pressure/drug effects , Bone Density Conservation Agents/administration & dosage , Calcium, Dietary/administration & dosage , Pre-Eclampsia/prevention & control , Pregnancy Complications, Cardiovascular/prevention & control , Adult , Argentina , Blood Pressure Determination/methods , Double-Blind Method , Female , Humans , Pregnancy , Risk Assessment , South Africa , Treatment Outcome , World Health Organization , Zimbabwe
10.
S Afr Med J ; 105(4): 271-4, 2015 Apr.
Article in English | MEDLINE | ID: mdl-26294865

ABSTRACT

Maternal deaths due to haemorrhage continue to increase in South Africa (SA). It appears that oxytocin and other uterotonics are not being used optimally, even though they are an essential part of managing maternal haemorrhage. Oxytocin should be administered to every mother delivering in SA. Awareness is required of the side-effects that can occur and the appropriate measures to avoid harm from these. Second-line uterotonics should also be available and utilised in conjunction with mechanical and surgical means to arrest haemorrhage in women who continue to bleed after the appropriate administration of oxytocin.


Subject(s)
Mothers/statistics & numerical data , Oxytocin/pharmacology , Postpartum Hemorrhage/prevention & control , Female , Humans , Maternal Death/trends , Oxytocics/pharmacology , Postpartum Hemorrhage/epidemiology , Pregnancy , Safety , South Africa/epidemiology
11.
S Afr Med J ; 105(4): 287-91, 2015 Apr.
Article in English | MEDLINE | ID: mdl-26294872

ABSTRACT

BACKGROUND: In the latest (2011-2013) Saving Mothers report, the National Committee for Confidential Enquiries into Maternal Deaths in South Africa (SA) (NCCEMD) highlights the large number of maternal deaths associated with caesarean section (CS). The risk of a woman dying as a result of CS during the past triennium was almost three times that for vaginal delivery. Of all the mothers who died during or after a CS, 3.4% died during the procedure and 14.5% from haemorrhage afterwards. Including all cases of death from obstetric haemorrhage where a CS was done, there were 5.5 deaths from haemorrhage for every 10,000 CSs performed. OBJECTIVE: To scrutinise the contribution or effect of the surgical procedure on the ultimate cause of death by a cross-cutting analysis of the 2011-2013 national data. METHODS: Data from the 2011-2013 triennial review were entered into an Excel database and analysed on a national and provincial basis. RESULTS: There were 1,243 maternal deaths where a CS was the mode of delivery and 1 471 deaths after vaginal delivery. More mothers died as a result of CS in the provinces where there is a low overall CS rate. The following CS categories were identified as specific problems: bleeding during or after CS, pre-eclampsia and eclampsia, anaesthesia-related deaths, pregnancy-related sepsis and acute collapse and embolism. CONCLUSION: This is an area of concern, and a concentrated effort should be done to make CS in SA safer. Several recommendations are


Subject(s)
Cesarean Section/mortality , Delivery, Obstetric/mortality , Maternal Death/statistics & numerical data , Mothers/statistics & numerical data , Female , Humans , Maternal Mortality/trends , Pregnancy , Retrospective Studies , South Africa/epidemiology
12.
BJOG ; 121 Suppl 4: 53-60, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25236634

ABSTRACT

The Confidential Enquiry into Maternal Deaths (CEMD) in South Africa has been operational for 15 years. This case study describes the process of notification and independent assessment of maternal deaths, predominantly in facilities. In the earlier years of the Enquiry, institutional maternal mortality ratio increased and was 176.2 per 100 000 live births in the 2008-10 triennium; thereafter it decreased to 146.7 in the 2011/12 period. The slow progress was due to the significant contribution of HIV/AIDs to maternal mortality and challenges in implementing the recommendations that were devised from the findings of the Enquiry. Nevertheless, the CEMD process has been maintained and strengthened so it is currently able to perform routine maternal death surveillance at both national and district levels, identify deficiencies within the health system, generate reports and also provide early warning about alarming trends such as the increasing numbers of deaths due to caesarean-section-associated haemorrhage.


Subject(s)
Maternal Mortality , Confidentiality , HIV Infections/epidemiology , Humans , Maternal Mortality/trends , Organizational Case Studies , Population Surveillance , South Africa/epidemiology
14.
S Afr Med J ; 97(6): 461-4, 2007 Jun.
Article in English | MEDLINE | ID: mdl-17691479

ABSTRACT

OBJECTIVES: We analysed knowledge and expectations of the process and pain of labour in primigravidas attending a local midwifery obstetric unit (MOU). It was anticipated that the results of this study could inform the development of interventions aimed at improving the analgesic care of women delivering at primary health care obstetric units. DESIGN: Qualitative analysis of data obtained from in-depth semi-structured interviews. SETTING: A Cape Town MOU. SUBJECTS: 30 black African, Xhosa-speaking primigravidas. OUTCOME MEASURES: An open-ended interview guide was developed. The themes explored included previous painful experiences, knowledge of labour, expectations of and attitudes towards labour pain, and knowledge of biomedical analgesia. RESULTS: Patients were poorly informed about the process and pain of labour. Most women appeared highly motivated concerning their ability to cope with labour. Most expected pain, but had no concept of the severity or duration of the pain, and knew very little concerning methods available for pain relief in labour. CONCLUSION: Women at this MOU were poorly prepared for the experience of delivery. Antenatal programmes should incorporate sensitive education concerning the process and pain of labour and the methods available to alleviate pain.


Subject(s)
Health Knowledge, Attitudes, Practice , Labor Pain , Labor, Obstetric , Adolescent , Adult , Analgesia, Obstetrical , Cohort Studies , Female , Gravidity , Humans , Needs Assessment , Patient Education as Topic , Pregnancy , South Africa
15.
BJOG ; 114(8): 994-1002, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17578470

ABSTRACT

OBJECTIVE: To determine the effects of magnesium supplementation in pregnancy on the incidence of hypoxic-ischaemic encephalopathy (HIE). DESIGN: A randomised double-blind placebo-controlled study. SETTING: A Midwife Obstetric Unit and its two referral hospitals in Cape Town, South Africa. POPULATION: A group of 4494 black pregnant women of low socio-economic status. METHOD: Mothers, from the time of booking until delivery, were randomised to receive two identical tablets daily, containing either 128 mg slow-release magnesium stearate or lactose sugar. MAIN OUTCOME MEASURES: Primary: The incidence of HIE. Secondary: The incidence of fetal heart rate decelerations, term Stillbirths, Low Apgar Scores, Meconium Aspiration Pneumonia. RESULTS: The incidence of HIE (0.9%) was considerably less than anticipated (2%). There were 22 infants in the placebo group and 15 infants in the supplemented group (P = 0.279). The difference was not significant. Secondary outcomes such as late fetal heart rate decelerations (P = 0.002) and term stillbirths (P = 0.016) were reduced significantly in the supplemented group, but this finding needs further substantiation. CONCLUSIONS: Magnesium supplementation did not reduce the incidence of HIE significantly, probably because the study was underpowered and compliance was relatively poor.


Subject(s)
Stearic Acids/administration & dosage , Adolescent , Adult , Apgar Score , Arrhythmias, Cardiac/etiology , Delayed-Action Preparations , Dietary Supplements , Double-Blind Method , Female , Fetal Heart , Humans , Hypoxia-Ischemia, Brain , Infant, Newborn , Meconium Aspiration Syndrome/etiology , Middle Aged , Pilot Projects , Pregnancy , Pregnancy Outcome , Stillbirth
16.
BJOG ; 112(9): 1257-63, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16101605

ABSTRACT

OBJECTIVE: To audit trends in maternal mortality in the Peninsula Maternal and Neonatal Service (PMNS) over a 50-year period, with respect to rates and patterns of causation. DESIGN: Retrospective and prospective audit. SETTING: The PMNS, an integrated perinatal service composed of primary, secondary and tertiary facilities in Cape Town. Population All women giving birth in the area of the Cape Peninsula served by the PMNS over the 50-year period. METHODS: Data on maternal deaths were collected for 1953-2002 inclusive, from annual obstetric and gynaecological reports. Three triennia (1954-1956, 1981-1983 and 1999-2001) were selected for a detailed comparison of trends in rates and causes of death. MAIN OUTCOME MEASURES: Maternal mortality rates (MMRs). Causes of maternal deaths. RESULTS: Total deliveries increased from 7315 in 1953 to 27,575 in 2002. The MMR declined from 301 deaths per 100,000 deliveries in 1953 to 31.2 in the triennium, 1987-1989. From 1999, the MMR increased, reaching 112 in 2002. Comparing 1954-1956 (MMR of 253.9) with 1981-1983 (MMR of 43.8), there was a marked decline in the MMR related to hypertension (80.4 to 11.3), haemorrhage (50.8 to 4.2), abortion (55 to 4.2), suspected pulmonary embolism (25.4 to 2.8), pregnancy-related sepsis (8.5 to 4.2) and cardiac disease (21.2 to 2.8). Comparing 1981-1983 (MMR of 43.8) with 1999-2001 (MMR of 59.4), there was a decline in the MMR associated with abortion (4.2 to 0). The MMR for haemorrhage, suspected pulmonary embolism and cardiac disease remained the same. There was a slight increase in the MMR attributed to hypertension (11.3 to 14.5) and pregnancy-related sepsis (4.2 to 7.3). There was a marked increase in the MMR associated with non-pregnancy-related infections/AIDS (4.2 to 18.2). CONCLUSIONS: The MMR for all causes of maternal death declined significantly from 1953 to 1981 as a result of several interventions. From 1999, there has been a non-significant increase in MMR, predominantly due to the burden of HIV/AIDS-related mortality.


Subject(s)
Maternal Mortality , Pregnancy Complications/mortality , Cause of Death , Confidence Intervals , Female , HIV Infections/mortality , Humans , Medical Audit , Pregnancy , Pregnancy Complications, Infectious/mortality , Prospective Studies , Retrospective Studies , South Africa/epidemiology
17.
Acta Paediatr ; 93(6): 779-85, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15244227

ABSTRACT

AIM: Conventional care of prematurely born infants involves extended maternal-infant separation and incubator care. Recent research has shown that separation causes adverse effects. Maternal-infant skin-to-skin contact (SSC) provides an alternative habitat to the incubator, with proven benefits for stable prematures; this has not been established for unstable or newborn low-birthweight infants. SSC from birth was therefore compared to incubator care for infants between 1200 and 2199 g at birth. METHODS: This was a prospective, unblinded, randomized controlled clinical trial; potential subjects were identified before delivery and randomized by computerized minimization technique at 5 min if eligible. Standardized care and observations were maintained for 6 h. Stability was measured in terms of a set of pre-determined physiological parameters, and a composite cardio-respiratory stabilization score (SCRIP). RESULTS: 34 infants were analysed in comparable groups: 3/18 SSC compared to 12/13 incubator babies exceeded the pre-determined parameters (p < 0.001). Stabilization scores were 77.11 for SSC versus 74.23 for incubator (maximum 78), mean difference 2.88 (95% CI: 0.3-5.46, p = 0.031). All 18 SSC subjects were stable in the sixth hour, compared to 6/13 incubator infants. Eight out of 13 incubator subjects experienced hypothermia. CONCLUSION: Newborn care provided by skin-to-skin contact on the mother's chest results in better physiological outcomes and stability than the same care provided in closed servo-controlled incubators. The cardio-respiratory instability seen in separated infants in the first 6 h is consistent with mammalian "protest-despair" biology, and with "hyper-arousal and dissociation" response patterns described in human infants: newborns should not be separated from their mothers.


Subject(s)
Anxiety, Separation/physiopathology , Incubators, Infant , Infant Care/methods , Infant, Low Birth Weight/physiology , Infant, Premature/physiology , Skin , Birth Weight , Female , Gestational Age , Heart Rate , Humans , Infant, Newborn , Male , Mother-Child Relations , Oxygen Consumption , Respiration
19.
Int J Gynaecol Obstet ; 72(3): 215-21, 2001 Mar.
Article in English | MEDLINE | ID: mdl-11226441

ABSTRACT

OBJECTIVE: To evaluate the efficacy of oral misoprostol for the induction of labor (IOL) in women with prelabor rupture of membranes at term (PROM) and to monitor maternal or fetal complications. METHOD: This randomized, placebo controlled trial was performed in a secondary referral hospital. The data of 47 patients in the misoprostol--and 49 patients in the placebo group was available for analysis. The former received 100 microg misoprostol orally, repeated once after 6 h if not in active labor, the latter received two doses of vitamin C also after a 6-h interval. The Mann-Whitney U-test was used for analysis. RESULTS: The median treatment to delivery interval in the misoprostol group was 7.5 h and 25 h in the placebo group (P<0.001). No significant differences were found in the incidence of abnormalities on the cardiotocograph, mode of delivery, neonatal outcome, use of antibiotics for the mothers and patient acceptability. CONCLUSION: Oral misoprostol in the suggested dose is an effective and cheap alternative for IOL in patients with PROM. No adverse effects could be demonstrated.


Subject(s)
Fetal Membranes, Premature Rupture/drug therapy , Misoprostol/therapeutic use , Oxytocics/therapeutic use , Administration, Oral , Female , Humans , Misoprostol/administration & dosage , Oxytocics/administration & dosage , Pregnancy , Pregnancy Outcome , Pregnancy Trimester, Third
20.
Stud Fam Plann ; 28(3): 228-34, 1997 Sep.
Article in English | MEDLINE | ID: mdl-9322338

ABSTRACT

In 1994, a national hospital-based study was undertaken of cases of incomplete abortion presenting to public hospitals in South Africa. Data were collected for all women admitted to a random sample of hospitals with incomplete abortion during a two-week period. The WHO protocol for such studies was used as a basis for developing the methods to describe the epidemiology of incomplete abortion and hospital management of cases. Attempts were made to estimate the proportion of cases that might have been induced. This report focuses on methodological issues arising from the study that have implications for future research. The findings demonstrate that only a small proportion of the women acknowledged having had an induced abortion and that only a few of those who did showed evidence of interference with pregnancy. Clinical opinion of sepsis and the likelihood of induction were found to be highly unreliable. These findings considerably reduce the usefulness of the WHO-protocol method of estimating the likely origin of incomplete abortions. Results presented in terms of three partially overlapping descriptive categories are judged to better reflect the limitations of the data collected.


Subject(s)
Abortion, Incomplete/epidemiology , Abortion, Induced/statistics & numerical data , Abortion, Spontaneous/epidemiology , Research Design/standards , Abortion, Incomplete/therapy , Abortion, Spontaneous/therapy , Bias , Female , Hospitals, Public , Humans , Pregnancy , Prevalence , Prospective Studies , Reproducibility of Results , South Africa/epidemiology , World Health Organization
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