Biologic Approaches for the Treatment of Partial Tears of the Anterior Cruciate Ligament: A Current Concepts Review.

BACKGROUND: Anterior cruciate ligament reconstruction (ACLR) has been established as the gold standard for treatment of complete ruptures of the anterior cruciate ligament (ACL) in active, symptomatic individuals. In contrast, treatment of partial tears of the ACL remains controversial. Biologically augmented ACL-repair techniques are expanding in an attempt to regenerate and improve healing and outcomes of both the native ACL and the reconstructed graft tissue. PURPOSE: To review the biologic treatment options for partial tears of the ACL. STUDY DESIGN: Review. METHODS: A literature review was performed that included searches of PubMed, Medline, and Cochrane databases using the following keywords: partial tear of the ACL, ACL repair, bone marrow concentrate, growth factors/healing enhancement, platelet-rich plasma (PRP), stem cell therapy. RESULTS: The use of novel biologic ACL repair techniques, including growth factors, PRP, stem cells, and bioscaffolds, have been reported to result in promising preclinical and short-term clinical outcomes. CONCLUSION: The potential benefits of these biological augmentation approaches for partial ACL tears are improved healing, better proprioception, and a faster return to sport and activities of daily living when compared with standard reconstruction procedures. However, long-term studies with larger cohorts of patients and with technique validation are necessary to assess the real effect of these approaches.

Meniscal root tears: a classification system based on tear morphology.

BACKGROUND: Meniscal root tears present in many forms and can have profound consequences on the health of knee articular cartilage. While the biomechanics, natural history, and treatment of root tears have been increasingly investigated, the spectrum of meniscal root tear patterns observed during arthroscopic examination has yet to be defined and categorized. PURPOSE: To establish a classification system for meniscal root tears by reporting the morphology of meniscal root tears from a consecutive series of arthroscopic surgeries. It was hypothesized that meniscal root tears could be grouped into types by distinct tear patterns and that recognition of tear pattern would affect treatment choice. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: All patients who underwent arthroscopic surgery from April 2010 to May 2014 by a single orthopaedic surgeon were included. After arthroscopic examination, data regarding the integrity of the meniscal roots were prospectively recorded in a data registry. Tear morphology and treatment received were subsequently extracted by 2 independent reviewers from operative notes and arthroscopic surgical photos. RESULTS: A total of 71 meniscal root tears in 67 patients were grouped into tear types with similar tear morphologies. Meniscal root tear patterns were categorized into partial stable root tears (type 1; n = 5); complete radial tears within 9 mm of the bony root attachment (type 2; n = 48), further subclassified into types 2A, 2B, and 2C, located 0 to <3 mm, 3 to <6 mm, and 6 to 9 mm from the root attachment, respectively; bucket-handle tears with a complete root detachment (type 3; n = 4); complex oblique tears with complete root detachments extending into the root attachment (type 4; n = 7); and bony avulsion fractures of the root attachments (type 5; n = 7). CONCLUSION: This study demonstrated that it was possible to establish a concise classification system to group patients with meniscal root tears by tear morphology. Treatments received varied across tear types.

Consequences of tibial tunnel reaming on the meniscal roots during cruciate ligament reconstruction in a cadaveric model, Part 2: The posterior cruciate ligament.

BACKGROUND: Recent emphasis has turned to reconstructing the posterior cruciate ligament (PCL) after injury. However, single-bundle PCL reconstruction of the anterolateral bundle may potentially injure the posterior meniscal roots. PURPOSE/HYPOTHESIS: The purpose of this study was to determine if posterior meniscal root injuries occurred because of tunnel reaming for single-bundle PCL reconstruction. It was hypothesized that tibial tunnel reaming within the anterolateral bundle footprint during PCL reconstruction would result in clinically significant decreases in posteromedial (PM) root attachment areas and in ultimate failure strength for the PM root. STUDY DESIGN: Controlled laboratory study. METHODS: Testing was performed on 12 matched pairs of human cadaveric knees. For each pair of knees, one knee was left intact, while the contralateral knee was prepared with a tibial tunnel placed 5 mm anterior to the center of the tibial PCL attachment and within the previously described footprint of the anterolateral bundle of the PCL for single-bundle PCL reconstruction. The attachment areas of the posterior meniscal roots were measured with a coordinate measuring device before and after PCL tunnel reaming. The posterior meniscal roots were then pulled to failure with a dynamic tensile testing machine. RESULTS: There was a significant mean decrease in the attachment area of the PM root (%Δ, 28%; 95% CI, 16-40) after PCL tunnel reaming compared with the intact state (P=.005). The mean ultimate failure strength of the native PM root (mean, 440 N; 95% CI, 347-534) was also significantly stronger (mean, 40%; 95% CI, 18-61; P=.005) than that of the PM root after PCL tunnel reaming (mean, 243 N; 95% CI, 176-309). No changes were found for the posterolateral (PL) root after PCL tunnel reaming. CONCLUSION: Tibial tunnel reaming for single-bundle PCL reconstruction in the anterolateral bundle footprint significantly reduced the ultimate failure strength and attachment area of the PM meniscal root. The attachment area and ultimate failure strength of the PL root were unaffected by tunnel reaming. CLINICAL RELEVANCE: Tibial tunnels reamed in the footprint of the anterolateral bundle during single-bundle PCL reconstruction can cause iatrogenic damage to the PM meniscal root attachment. Thus, tibial tunnels should strive to be reamed in the center of the entire tibial PCL attachment site during PCL reconstruction.

Consequences of tibial tunnel reaming on the meniscal roots during cruciate ligament reconstruction in a cadaveric model, Part 1: The anterior cruciate ligament.

BACKGROUND: The current standard for treating complete tears of the anterior cruciate ligament (ACL) is reconstruction, which requires reaming a tibial tunnel. Based on recent anatomic and biomechanical studies, this reconstruction tunnel may cause injuries to the anterior meniscal root attachments. PURPOSE/HYPOTHESIS: The purpose was to determine if injuries occurred to the anteromedial (AM) and anterolateral (AL) meniscal root attachments because of reaming a tibial reconstruction tunnel in the anatomic center of the ACL footprint. It was hypothesized that tibial tunnel reaming for ACL reconstruction would result in significant decreases in the attachment area and in ultimate failure strength for the AL root. STUDY DESIGN: Controlled laboratory study. METHODS: Twelve matched pairs of human cadaveric knees were tested. One knee from each pair remained intact, while the contralateral knee was reamed with a tibial tunnel for an anatomic ACL reconstruction. The attachment areas of the anterior meniscal roots were measured with a coordinate measuring device before and after tunnel reaming. The anterior meniscal roots were then pulled to failure with a dynamic tensile testing machine. RESULTS: There was a significant mean decrease in the attachment area for the AL root (%Δ, 38%; 95% CI, 25-51) after ACL tunnel reaming compared with the intact state (P=.003). The mean ultimate failure strength of the native AL root (mean, 610 N; 95% CI, 470-751) was significantly stronger (P=.015) than that of the AL root with a reamed ACL reconstruction tunnel (mean, 506 N; 95% CI, 353-659). Tunnel reaming did not significantly affect the AM root attachment area or ultimate failure strength. CONCLUSION: Tibial tunnel reaming during anatomic single-bundle ACL reconstruction significantly decreased the AL meniscal root attachment area and ultimate failure strength. The AM root was not significantly affected by reaming of the ACL reconstruction tunnel. Future studies should investigate the clinical importance of these iatrogenic injuries to the AL root. CLINICAL RELEVANCE: The ACL reconstruction tunnels reamed in the center of the ACL tibial footprint caused a significant decrease in the attachment area and ultimate strength of the AL meniscal root attachment. Clinically, repositioning guide pins placed in the lateral aspect of the ACL attachment before tibial tunnel reaming may minimize iatrogenic injuries to the AL meniscal root attachment.

Repair of a complete radial tear in the midbody of the medial meniscus using a novel crisscross suture transtibial tunnel surgical technique: a case report.

Complete radial meniscus tears have been reported to result in deleterious effects in the knee joint if left unrepaired. An emphasis on meniscal preservation is important in order to restore native meniscal function. In this case report, a complete radial tear of the medial meniscus midbody was repaired using a novel crisscross suture transtibial technique. This technique secured the anterior and posterior meniscal horns, which were released from their extruded and scarred position along the capsule, using crisscrossing sutures passed through two transtibial tunnels and secured over a bone bridge on the anterolateral tibia. In addition, the repair was supplemented with the injection of platelet-rich plasma and bone marrow aspirate concentrate to promote the healing of the meniscal tissue. Complete healing on second-look arthroscopy is presented, including in the previously unreported white-white meniscal zone.

Isolated tears of the anterior cruciate ligament: over 30-year follow-up of patients treated with arthrotomy and primary repair.

BACKGROUND: Over 30 years ago, Feagin and Curl reported on the diagnosis and treatment of "isolated" injuries of the anterior cruciate ligament (ACL). The purpose of this study was to evaluate the long-term results of the patients initially diagnosed with tears of the ACL, with special emphasis on those treated with primary repair. HYPOTHESIS: Long-term results are unsatisfactory for open evaluation and treatment of ACL injuries with or without primary repair. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Follow-up was available on 34 of the original 57 patients (60%) who had ACL tears on evaluation by arthrotomy. The average age at the index procedure was 20 years, and average follow-up was 32 (range, 29-36) years. Twenty-five of the 26 complete ACL tears were treated with primary repair. None of the 8 partial tears was repaired. Evaluations included the subjective and symptom ratings of the International Knee Documentation Committee (IKDC) evaluation form, Lysholm score, Knee Injury and Osteoarthritis Outcome Score (KOOS), Tegner activity scale, and SANE rating. RESULTS: For the IKDC subjective score, 18 of 34 patients rated their knees as normal or nearly normal. The Lysholm scores averaged 70.1 (range, 20-100). The average SANE rating at 5 years was 74.8 (range, 49-110), and the current SANE rating averaged 68.9 (range, 10-100). The overall KOOS rating averaged 68.6 (range, 26.4-100). The Tegner activity score was 3.7. There was little difference between patients with unrepaired partial tears and those who had primary repairs. CONCLUSION: At more than 30-year follow-up, patients have decreased activity levels and an equal mix of acceptable and unacceptable outcomes. We were unable to identify any predictive factors that correlated with the results; however, subsequent meniscal surgery did correlate with poor results. The results at greater than 30 years reinforce the 5-year results that showed unsatisfactory results after the open evaluation and treatment of ACL injuries with or without repair.

Implications of the pivot shift in the ACL-deficient knee.

UNLABELLED: The Losee repair controls rotational subluxation of the lateral femoral condyle, or pivot shift, but does not reliably eliminate Lachman laxity. Despite this surgical limitation, many patients who were operated on continued to do high-demand activities at the last followup. We hypothesized that Lachman findings alone did not predict poor surgical outcome or progression to osteoarthritis. We report on 87 patients evaluated at an average of 9 years (range, 5-21 years) postoperatively. Prospectively collected examinations and radiographic, subjective, and objective outcome measures were recorded and statistically evaluated. The presence of a postoperative pivot shift or residual varus laxity correlated with poor patient subjective evaluations and poor scoring outcomes. Lachman laxity with an absent pivot shift had no correlation with the outcome measures or onset of radiographic progression to osteoarthritis. Meniscectomy, additional knee surgery, increased valgus or varus laxity, and time from injury until the final radiograph positively correlated with the onset of osteoarthritis. Elimination of the pivot shift was necessary to achieve successful relief of symptoms and functional outcome. In the absence of a pivot shift, Lachman laxity was not solely predictive of poor outcomes. LEVEL OF EVIDENCE: Prognostic study, Level II-1 (retrospective study). See the Guidelines for Authors for a complete description of levels of evidence.