1.
Bioorg Med Chem Lett
; 13(8): 1495-8, 2003 Apr 17.
Article
in English
| MEDLINE
| ID: mdl-12668020
ABSTRACT
Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and long half-life have been elusive. We report here a novel series non-peptidic phenyl-based, highly potent, highly selective and orally bioavailable thrombin inhibitors using oxyguanidines as guanidine-mimetics.