[Immunohistochemical investigation of estrogen and progesterone receptors in breast tumors]. / Immunogistokhimicheskoe issledovanie retseptorov éstrogenov i progesterona v rake molochnoi zhelezy.

Estrogen (ER) and progesterone (PR) receptor levels were assayed in 344 breast tumors. The following 4 patterns were identified: ER+ PR(+)--61%; ER+ PR- 24%; ER- PR(+)--15% and ER- PR(-)--35%. While no correlation was found between histological pattern, on the one hand, and the ER/PR ratio and age, on the other, there was one between estrogen and progesterone receptor content, on the one hand, and age, tumor size and metastatic spread to regional lymph nodes, on the other (p > 0.001).

[Comparative clinical evaluation of the effectiveness of modified radical mastectomy and organ-preserving therapy in localized breast cancer (pT1-2N0M0)]. / Sravnitel'naia klinicheskaia otsenka éffektivnosti modifitsirovannoi radikal'noi mastéktomii i organosokhraniaiushchego lecheniia pri lokalizovannykh formakh raka molochnoi zhelezy (pT1-2N0M0)

The outcome of 320 patients with breast tumors was followed. Modified total mastectomy with subsequent irradiation, chemo- and/or hormone therapy was given to 164 patients. Limb-saving surgery was performed in 156. Incidence of locally advanced recurrences did not differ significantly in the two groups--3.7 and 5.5%, respectively. Nor did 5-year overall (90 +/- 1.4% and 88.4% +/- 1.6%, respectively) and relapse-free survival (88.4 +/- 1.2% and 83.5 +/- 1.4%, respectively) (p < 0.05). Hence, mastectomy is not worth more than sparing treatment.

[Successful surgical treatment of cancer with multiple location]. / Uspeshnoe khirurgicheskoe lechenie raka mnozhestvennoi lokalizatsii.

The lecture deals with the specific characteristics of cell membrane damage caused by in vivo and in vitro irradiation at the dosage commonly used in radiation therapy of malignant tumors. The mechanisms of lymphoid cell loss to ionizing radiation are described. They include metabolic depletion, direct damage to the cell membrane causing loss of its asymmetry and surface receptors expression being altered.