[Magnetic-laser influence on the system of nitric oxide and contractile activity of smooth muscles of rat aorta under hypertension].

The study was conducted on three groups of rats: Group I included Wistar rats with normal blood pressure (first control group); group II - rats with genetically determined hypertension (second control group); group Ill - rats with genetically determined hypertension under the influence ofmagnetic-laser power (study group). For the low-intensively magnetic-laser influence (MLI) we have used device MIT-MT, Ukraine, which was designed for the treatment of low-frequency magnetic field using optical flow blue and red ranges of spectrum. The MLI duration was 15 minutes for the blue range, and 25 minutes for the red one. Biochemical studies included the determination of the activity of isoenzymes of NO-synthase: constitutive (cNOS) and inducible (iNOS), the content of free hemoglobin, stable metabolites of NO, namely nitrite - (NO2(-)) and nitrate - (NO3(-)) anions, resistance to acid hemolysis of red blood cells. The contractile activity of smooth muscles of the aorta was measured. We found that magnetic-laser exposure of rats with genetically determined hypertension in the red (630 nm) and blue (470 nm wavelength) optical range even after a single session leads to an increased synthesis of nitric oxide in the blood plasma. Our data sindicate that the most effective in the intensification of endogenous nitric oxide (increase of NO2(-) and reduction of NO3(-)) and endothelium-dependent responses of aorta in rats with genetically determined hypertension was a ten-day course of the magnetic-laser exposure in the optical flow of the blue spectral range. Also, after 10 sessions of magnetic-laser exposure in rats from the above specified spectrum a stabilization of erythrocyte membranes was observed.

[Individual heart functioning variability under exposure to equal physical factors in patients with different vegetative system tone].

The article describes changes in heart rhythm variability (HRV) as a response to equal complex physical factors (hyperthermia of 60 degrees C with low relative humidity of 8 to 15%, air ionization, thalasso, and relaxing music). The subjects of the study were 28 individuals having no verified chronic diseases, who underwent a course of five recovery procedures using exposure to a complex of weak physical factors realized in Ionic House technology (Japan). The study found that changes in heart functioning as a response to equal physical factors depended on the initial vegetative system tone. Patients with normotonic and sympathicotonic heart regulation displayed the activation of parasympathetic vegetative nervous system as a result of a single exposure to a complex of physical factors, whereas in vagotonic patients sympathetic heart regulation was activated under the same conditions.

[Pefloxacin mesylate--clinical effectiveness in various forms of infectious-inflammatory diseases]. / Pefloksatsina mezilat--klinicheskaia éffektivnost' pri formakh infektsionno-vospalitel'nykh zabolevanii.

Pefloxacin mesylate is a broad spectrum fluoroquinolone active against pathogens with multiple resistance. Due to its high therapeutic efficacy (at last 90 per cent) and good tolerance pefloxacin mesylate is considered as the most promising drug in the therapy of severe infections and infections difficult for the treatment such as wound infection, meningitis and particularly perilous infections. Prolonged pharmacokinetics and high bioavailability of the drug provided its administration in the treatment of in- and outpatients with severe infection twice a day in a daily dose of 0.8 to 1.2 g. Pefloxacin proved to be a drug of choice in the treatment of infection due to intracellular pathogens.

[Chemiluminescent analysis of the functional state of cellular and humoral components of neutrophil phagocytosis system in recurrent herpes simplex]. / Khemiliuminestsentnyi analiz funktsional'nogo sostoianiia kletochnogo i gumoral'nogo zven'ev sistemy neitrofil'nogo fagotsitoza pri retsidiviruiushchei virusnoiinfektsii herpes simplex.

Methods of chemiluminescent analysis of the opsonin-phagocytic system in patients with recurrent herpes simplex and of assessment of in vitro cell sensitivity to immunomodulating agents in the same test are described. The functional activity of neutrophils and opsonizing capacity of the blood sera of patients with herpes simplex infection were found appreciably reduced. Chemiluminescent analysis was found useful for the selection of individual immunocorrecting therapy.

[Cellular immunity in patients with gonorrhea and gonorrhea-chlamydia infection during treatment with pefloxacin in combination with thymogen]. / Osobennosti kletochnogo immuniteta u bol'nykh gonoreinoi i gonoreino-khlamidinoi infektsiei pri lechenii pefloksatsinom v sochetanii s timogenom.

The ultrastructural analysis showed that under the effect of abaktal (pefloxacin) the incomplete phagocytic reaction completed, the phagocytosis being of the multistage character. The morphometric analysis of the blood leukoconcentrate revealed an increase in the polymorph digestion function after the exposure to combinations of immunomodulators with abaktal which was in favour of the abaktal recommendation for the treatment of gonorrheal-chlamydial infection.

[Fluoroquinolones in the therapy of gonorrheal-chlamydial infection (a clinical and electron microscopic study)]. / Ftorkhinolony v terapii gonoreino-khlamidiinoi infektsii (kliniko-élektronnomikroskopicheskoe issledovanie).

Highly efficient methods for the treatment of gonorrheal and gonorrheal-chlamydial infections with fluorquinolones were developed and introduced into medical practice. The methods are pathogenetically substantiated. The etiological recovery in the patients treated with tarivid, quintorom and abaktal amounted to 97.8, 96 and 95.6 per cent respectively. The subcellular examinations of ultrathin sections of the pathological material from the patients with gonorrheal-chlamydial infection showed that the association of gonococcus and Chlamydia resulted in hyperproduction of drop-like formations that had a toxic action on leukocytes in the infection foci.

[The results of using emoxipine in true eczema]. / Rezul'taty primeneniia émoksipina pri istinnoi ékzeme.

The detected enhancement of lipid peroxidation processes in patients with acute eczema calls for administration of emoxipin, a Soviet synthetic antioxidant, characterized by a wide pharmacologic spectrum. Emoxipin therapy of 39 patients with acute eczema resulted in clinical remission and a considerable improvement of the skin process, parallelled by normalization of lipid peroxidation processes and reduction of the treatment duration.

[Lipid peroxidation in patients with true eczema]. / Perekisnoe okislenie lipidov u bol'nykh istinnoi ékzemoi.

Studies of lipid peroxidation (LPO) in 67 patients with true eczema have revealed a drastic intensification of this process, manifested by an increased level of malonic dialdehyde and elevated chemiluminescence values paralleled by reduced content of endogenous antioxidants. A tendency to a rise of the studied parameters was detected in the patients with chronic eczema during remissions. The findings point to a contribution of LPO processes to the pathogenesis of true eczema.

[The dynamics of the kallikrein-kinin system indices in patients with eczema vera during treatment by the laser photophoresis method with ortofen]. / Dinamika pokazatelei kallikrein-kininovoi sistemy u bol'nykh istinnoi ékzemoi v protsesse lecheniia metodom lazernogo fotoforeza s ortofenom.

A drastic increase (by 30.6 times) vs. the norm) of kallikrein activity was revealed in 70 patients with true eczema during exacerbation; blood plasma amidase activity was elevated 4.4-fold, serum alpha 2 macroglobulin antiprotease activity 1.4-fold. Laser photophoresis combined with application of a new Soviet nonsteroid anti-inflammatory agent orthofen reduced the parameters of the kallikrein-kinin system, and a tendency to their normalization could be observed.

[A case of Wegener's granulomatosis]. / Sluchai granulematoza Vegenera.

The described case of Wegener's granulomatosis evidences that this condition is difficult to diagnose and that it should be differentiated from tuberculosis, syphilis, pemphigus, deep mycosis. Late identification and beginning of therapy result in generalization of the process.

[Morphological skin changes in the action of complex mineral fertilizers]. / Morfologicheskie izmeneniia kozhi pri deistvii kompleksnykh mineral'nykh udobrenii.

Experimental study of the skin structure in exposure to mineral fertilizers (ammophos, nitroammophos) was carried out. Saturated solutions of fertilizers were applied to intact and scarified free of hair skin of the back of guinea pigs. Skin structure changes were more significant when the fertilizers were applied to scarified skin. The findings evidence the injurious toxic effects of mineral fertilizers on cellular structural components.

[The pathogenesis of dermatoses due to contact with mineral fertilizers]. / O patogeneze dermatozov, obuslovlennykh kontaktom s mineral'nymi udobreniiami.

The studies have revealed unfavourable effect of mineral fertilizers on the peripheral blood cells. A complex of tests was used to diagnose dermatoses induced by exposure to mineral fertilizers.

[Measures for the combined therapy and prevention of dermatoses occurring in workers in contact with organophosphorus pesticides]. / K voprosu o merakh kompleksnoi terapii i profilaktiki dermatozov, voznikaiushchikh u rabochikh, kontaktiruiushchikh s fosfororganicheskimi pestitsidami.

Allergenic and photosensitizing effects of organophosphorus pesticides (OPP) have been detected, as well as their destructive effect on the skin cell ultrastructure, on the body metabolism and enzymic systems, and the inhibitory effect on cholinesterase activity. Pesticide-induced changes in polyunsaturated fatty acids (PUFA) are significant in the mechanism of dermatoses development. The complex of treatment-and-prophylaxis measures includes regular dermatologic check-ups and limitation of the number of subjects handling OPP. Subjects in whom premorbid shifts have been detected, should be followed up. The therapy and prevention of the dermatoses developing as a result of exposure to pesticides may be effectively carried out with antioxidants, amino acids, vitamins, etc.; diets with the optimal PUFA-tocopherol ratio are advisable. Overalls with multiple protective physicochemical characteristics, filtering respirators and such are recommended.