ABSTRACT
It is shown in the experiments on rats that the atrophy of skeletal muscles which has developed as a result of disturbances of neurotrophic control leads to the changes in protein spectrum of sarcolemma, growth of activity of membrane-associated enzymes (Na+, K(+)-ATPase, Ca(2+)-ATPase), intensive functioning of the prooxidative and antioxidative system of the muscle fibers.
Subject(s)
Lipid Metabolism , Muscle Proteins/metabolism , Muscular Atrophy/metabolism , Sarcolemma/metabolism , Animals , Calcium-Transporting ATPases/metabolism , Lipid Peroxidation/physiology , Male , Muscle Denervation , Oxidation-Reduction , Rats , Sodium-Potassium-Exchanging ATPase/metabolismABSTRACT
Muscle proteins soluble in perchloric acid contain about 75% of carbohydrates presented by neutral hexoses, fucose and hexuronic acids. Three days and two weeks after denervation the content of the glycoproteids protein part is unchanged, a month later it increases by 116%. The content of carbohydrate component following denervation lowers considerably and a month later is on the average 40% higher than in the muscle of healthy rats. Administration of muscular RNA restores the content of the protein component only by the end of a month; administration of pyrogenal normalizes the content of both protein and carbohydrate components.
