[A clinical and experimental validation of the use of Stimuloss in patients with chronic generalized periodontitis]. / Kliniko-éksperimental'noe obosnovanie primeneniia u bol'nykh khronicheskim parodontitom "Stimulossa".

The pharmacological effect of hydroxyapatite and a composition based on it in the form of Stimulos sponge has been studied in human osteogenic tissue culture. Hydroxyapatite stimulated the biosynthetic processes in the cells. Addition of chlorohexidine and thymogen to the composition in order to increase its antibacterial activity did not decrease the osteoinductive properties of the drug. Trials of Stimulos in 66 patients with chronic generalized periodontitis demonstrated its high efficacy, particularly of the compositions containing immunostimulants: inflammation disappeared and the height of alveolar osseous tissue increased, as did bone compactness.

[An experimental and clinical study of Ossocol, a compound of hydroxylapatite and collagen]. / Izuchenie v éksperimente i klinike kompozitsii gidroksilapatita c kollagenom--"Ossokola".

Experiments on white rats revealed that introduction of Ossocol, a sponge with a composition of hydroxyl apatite with collagen, into a removed tooth well prevented mandibular atrophy and was conducive to a more smooth defect filling with better compact bone tissue. Ossocol use in 214 patients with bone tissue defects developing after tooth removal, of odontogenic cysts, sequestra, and after radical surgery for periodontal diseases demonstrated a positive effect of this agent on the course of the postoperative period: the defect was more rapidly replaced by bone tissue. No unfavorable local or general reactions to Ossocol implantation were observed.