ABSTRACT
AIM: To study free radical processes in patients with myocardial infarction (MI) aggravated by heart failure. MATERIAL AND METHODS: Forty seven patients taken to the clinic within the first 5 hours of MI were examined. The patients were divided into 2 groups: 1) those with left ventricular failure-complicated IM (n = 25); 2) those with uncomplicated MI (n = 22). A control group included 17 apparently healthy males. The activity of lipid peroxidation (LPO) and blood antioxidative defense was determined in the patients' red blood cells prewashed off the plasma with saline solution at a temperature of 4 degrees C. RESULTS: The tension of free radical lipid oxidation mechanisms in patients with MI aggravated by circulatory insufficiency is followed by an increased antiradical activity. In patients with uncomplicated higher LPO activity is attended the less marked activation of antioxidative enzymes. The examinees were found to show a correlation of the global systolic function of the left ventricle with the concentration of LPO products and with the activity of antioxidative enzymes. CONCLUSION: More significant LP activation coupled with left ventricular systolic dysfunction was noted in patients with MI aggravated by acute heart failure.
Subject(s)
Antioxidants , Heart Failure/etiology , Lipid Peroxidation , Myocardial Infarction/physiopathology , Free Radicals , Humans , Male , Myocardial Infarction/complications , Myocardial Infarction/metabolism , Stroke Volume , Time FactorsABSTRACT
AIM: To elucidate correlations between gas composition of blood, hemodynamic and electrophysiological parameters of the heart and effect of these indices on arrhythmia onset in patients with chronic obstructive bronchitis (COB). MATERIAL AND METHODS: "Rhythm" ECG, 24-h ECG monitoring, transesophageal pacing, heart ultrasonography were performed in 160, 67, 160 of 160 patients with chronic obstructive bronchitis (COB), respectively. 76 patients suffered from respiratory insufficiency (RI) degree 1 and 84 of RI degree 2. 58 patients free of RI served control. Gas composition of the blood and acid-base balance of the capillary blood were examined in 50 patients. RESULTS: Shortening of effective refractory atrial period and prolongation of interatrial conduction predispose to emergence of suptaventricular arrhythmia in COB patients with RI. With the onset and development of RI in COB patients, heart chamber size and myocardial function become more and more essential for cardiac electrophysiological parameters. For COB patients free of RI, gas composition of capillary blood is of key importance in this respect. CONCLUSION: The proposed complex clinicofunctional method for assessment of electrophysiological condition of the heart with evaluation of intracardiac hemodynamics and gas composition of the capillary blood is recommended for registration of signs of the onset and unfavorable progress of cardiac arrhythmia in COB patients with RI as well as for objective and safe control over effectiveness of treatment of such patients.
Subject(s)
Arrhythmias, Cardiac/diagnosis , Bronchitis/physiopathology , Carbon Dioxide/blood , Heart/physiopathology , Oxygen/blood , Adult , Bronchitis/blood , Chronic Disease , Data Interpretation, Statistical , Echocardiography , Electrocardiography , Electrocardiography, Ambulatory , Electrophysiology , Female , Hemodynamics , Humans , MaleABSTRACT
The aim of the study was to examine changes in vasodilatory endothelial function in early cerebrovascular disease of atherosclerotic genesis. All the examinees underwent ultrasonic investigation, test for reactive hyperemia of the brachial artery to evaluate vasodilatory function of the endothelium. Disturbances in the flow-dependent vasodilation were detected at initial stages of the disease, aggravated with the progress of cerebrovascular disease and therefore could serve the earliest, objective indicator of atherosclerotic process.
