Subject(s)
Prostatic Neoplasms/diagnosis , Aged , Female , Humans , Male , Prostatic Neoplasms/genetics , Risk FactorsABSTRACT
Iron balance is critical for adequate erythropoiesis in hemodialysis patients treated with recombinant human erythropoietin (EPO). The role of oral iron therapy in maintaining or replenishing iron stores has not yet been well defined in such patients. We undertook a double-blind, placebo-controlled study to evaluate the efficacy of oral iron in 49 hemodialysis patients, divided into two groups, based on adequate or deficient iron stores. These groups were treated for 3 months with 150 mg elemental iron (Polysaccharide complex, Central Pharmaceuticals) or placebo, twice daily. Laboratory parameters were followed for five months. These parameters included: hematocrit (Hct), ferritin, transferrin saturation (Tsat), and zinc protoporphyrin (ZPP). A side-effects questionnaire was recorded monthly. Our results indicate that iron replete patients show evidence of falling iron stores during the study period; this observation was identical in both oral iron and placebo subgroups. Iron deficient patients had a significantly greater drop-out rate due to side effects when compared to iron replete patients (33% vs. 8%), despite equivalent responses to the side-effect questionnaire. We conclude: 1) Oral iron fails to maintain iron stores in iron replete patients; 2) Iron deficiency observed in this study may be due to poor medication compliance rather than side-effects.
Subject(s)
Anemia, Iron-Deficiency/drug therapy , Erythropoietin/therapeutic use , Iron/therapeutic use , Polysaccharides/therapeutic use , Renal Dialysis , Administration, Oral , Anemia/drug therapy , Anemia/etiology , Anemia, Iron-Deficiency/etiology , Double-Blind Method , Female , Ferritins/blood , Follow-Up Studies , Humans , Kidney Failure, Chronic/complications , Kidney Failure, Chronic/therapy , Male , Middle Aged , Patient Compliance , Recombinant Proteins/therapeutic use , Time FactorsABSTRACT
Fibrous dysplasia is a disorder of bone that may be associated with endocrinopathies and skin pigmentation. The pathologic, proliferative expansion and distortion of the skeleton is of unknown etiology. Craniofacial involvement that includes the mandible can exhibit gigantic disproportions and dysfunction. Treatment has evolved to include more aggressive strategies of resection and sophisticated reconstructive techniques. The reported case is noteworthy for the unrelenting growth of craniofacial fibrous dysplasia in an adult female with endocrinopathies, progressing to oral obstruction that required urgent treatment utilizing immediate free bone-flap reconstruction. The free fibula flap was employed to restore mandibular continuity after palliative subtotal mandibulectomy. Bony healing to dysplastic tissue occurred in the remaining mandibular segment. This case illustrates that fibrous dysplasia has the capacity for virulent regrowth subsequent to conservative resection. Defects following radical surgery for giant fibrous dysplasia of the mandible can be reconstructed with a microsurgical bone-flap technique.
Subject(s)
Airway Obstruction/surgery , Facial Bones/abnormalities , Fibrous Dysplasia, Polyostotic/surgery , Mandible/surgery , Surgical Flaps/methods , Adult , Airway Obstruction/etiology , Female , Fibrous Dysplasia, Polyostotic/complications , Fibula/transplantation , HumansSubject(s)
Food Services/standards , Health Services for the Aged/standards , Nursing Homes/standards , Nutritional Physiological Phenomena , Aged , Food Services/legislation & jurisprudence , Health Services for the Aged/legislation & jurisprudence , Humans , Long-Term Care , Nursing Homes/legislation & jurisprudence , United States , WisconsinSubject(s)
Encephalitis, Viral/complications , Heart Arrest/etiology , Herpes Simplex/complications , Adult , Cardiac Pacing, Artificial , Electrocardiography , Encephalitis, Viral/diagnostic imaging , Encephalitis, Viral/virology , Heart Arrest/diagnosis , Herpes Simplex/diagnostic imaging , Humans , Male , Radiography , Tilt-Table TestABSTRACT
This report describes a patient who was treated for rejection of a cadaveric renal allograft with a variety of drugs, including the continuous administration of ciclosporin over a period of 16 months. The patient developed hyperuricemia, attacks of gout and finally a rapidly progressing renal failure 17 months after transplantation. The removed transplanted kidney showed extensive tubular dilatation, intratubular deposits of uric acid crystals and characteristic granulomas. There was also morphologic evidence of transplant glomerulopathy, as well as scattered linear parenchymal (cortical?) scars of the type seen in mild chronic ciclosporin toxicity. Both of these changes undoubtedly contributed to the reduction of renal reserve. However, we propose that prolonged continuous use of ciclosporin was the main factor in the development of hyperuricemia and obstructive hyperuricemic nephropathy and renal failure in this patient. To our knowledge cases of this nature have not been previously reported.
Subject(s)
Kidney Failure, Chronic/etiology , Kidney Transplantation/adverse effects , Uric Acid/blood , Adult , Cyclosporins/adverse effects , Cyclosporins/therapeutic use , Graft Rejection , Graft vs Host Disease/drug therapy , Humans , Kidney/metabolism , Kidney/pathology , Kidney/ultrastructure , Kidney Failure, Chronic/metabolism , Kidney Failure, Chronic/pathology , Male , Microscopy, Electron , Uric Acid/metabolismABSTRACT
Experiments were performed to determine the cause of the reduced glomerular filtration rate (GFR) in cyclosporine nephrotoxicity during compensatory renal growth. Sprague-Dawley rats were uninephrectomized and given daily injections of cyclosporine (30 mg/kg, i.m.) or vehicle (olive oil), and studied 7 or 14 days later. In cyclosporine treated rats GFR was lower seven days (1.34 +/- 0.10 vs. 1.68 +/- 0.07 ml/min) and 14 days (1.19 +/- 0.08 vs. 1.58 +/- 0.04, P less than 0.025) following uninephrectomy. Arterial blood pressure, cardiac output and renal blood flow (RBF) were not different in cyclosporine and control rats. Kidney mass increased to the same extent in cyclosporine and control rats. Micropuncture of the glomerular microcirculation in similarly prepared Munich-Wistar rats demonstrated low whole kidney GFR (1.10 +/- 0.07 vs. 1.55 +/- 0.13 ml/min, P less than 0.01), and single nephron GFR (31.07 +/- 2.27 vs. 42.36 +/- 2.47 nl/min, P less than 0.005) in cyclosporine treated rats as compared to controls. Single nephron plasma flow, afferent and efferent arteriolar resistance, the transglomerular hydrostatic pressure gradient, and arterial blood pressure were the same in both groups. The glomerular capillary ultrafiltration coefficient (Kf) was lower in cyclosporine treated rats compared to controls [0.039 +/- 0.002 vs. 0.075 +/- 0.013 nl/(sec.mm Hg), P less than 0.025]. We conclude that in this model of cyclosporine nephrotoxicity the low GFR is caused solely by a reduction in Kf, and that cyclosporine can reduce GFR without causing renal vasoconstriction.
Subject(s)
Cyclosporins/toxicity , Hemodynamics/drug effects , Kidney Glomerulus/blood supply , Renal Circulation/drug effects , Animals , Blood Pressure/drug effects , Body Weight/drug effects , Cardiac Output/drug effects , Glomerular Filtration Rate/drug effects , Kidney/drug effects , Kidney/pathology , Kidney Glomerulus/drug effects , Kidney Glomerulus/physiopathology , Nephrectomy , Rats , Rats, Inbred Strains , Regional Blood Flow/drug effectsABSTRACT
A series of HL-A defined, nonrelated blood transfusions given in small aliquots from the same donor to prospective cadaveric and living-related donor recipients has been presented. The results to date show 100% kidney survival in this small series over a relatively short period of time. The rejections noted have been very mild, and easily reversed. Nonspecific antibodies appear to be produced by the recipients in response to the blood, and these antibodies seem to have no negative effect upon kidney survival. This method of small aliquot transfusion to produce the desired effect is cheaper, wastes less blood, is less likely to lead to a CMV or HAA infestation in the transfusion recipient, and appears to be a highly efficient method of producing the desired effect.