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Obtaining of a virazole-resistant fowl plague virus mutant.

Indulen, M K; Feldblum, R L.

Acta Virol ; 26(1-2): 109, 1982 Jan.

Article in English | MEDLINE | ID: mdl-6124104

Subject(s)

Influenza A virus/genetics , Mutation , Ribavirin/pharmacology , Ribonucleosides/pharmacology , Animals , Birds , Drug Resistance , Humans , Influenza in Birds/microbiology , Influenza, Human/microbiology , Phenotype

Occurrence of amantadine- and rimantadine-resistant influenza A virus strains during the 1980 epidemic.

Heider, H; Adamczyk, B; Presber, H W; Schroeder, C; Feldblum, R; Indulen, M K.

Acta Virol ; 25(6): 395-400, 1981 Nov.

Article in English | MEDLINE | ID: mdl-6120642

ABSTRACT

The sensitivities to amantadine and rimantadine of influenza A virus epidemic strains were assayed by the haem-adsorption reduction test in mouse Ehrlich ascites cells in comparison with prototype strains and a rimantadine-resistant mutant. Besides a majority of sensitive strains, two relatively resistant epidemic strains were identified. The possible origin of resistant strains and their importance for medical practice are discussed.

Subject(s)

Adamantane/analogs & derivatives , Amantadine/pharmacology , Influenza A virus/drug effects , Rimantadine/pharmacology , Drug Resistance, Microbial , Humans , Influenza A virus/genetics , Mutation

Subject(s)

ABSTRACT

Subject(s)

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