A Review of Parallel Transmit Arrays for Ultra-High Field MR Imaging.

Parallel transmission (pTX) techniques are required to tackle a number of challenges, e.g., the inhomogeneous distribution of the transmit field and elevated specific absorption rate (SAR), in ultra-high field (UHF) MR imaging. Additionally, they offer multiple degrees of freedom to create temporally- and spatially-tailored transverse magnetization. Given the increasing availability of MRI systems at 7 T and above, it is anticipated that interest in pTX applications will grow accordingly. One of the key components in MR systems capable of pTX is the design of the transmit array, as this has a major impact on performance in terms of power requirements, SAR and RF pulse design. While several reviews on pTX pulse design and the clinical applicability of UHF exist, there is currently no systematic review of pTX transmit/transceiver coils and their associated performance. In this article, we analyze transmit array concepts to determine the strengths and weaknesses of different types of design. We systematically review the different types of individual antennas employed for UHF, their combination into pTX arrays, and methods to decouple the individual elements. We also reiterate figures-of-merit (FoMs) frequently employed to describe the performance of pTX arrays and summarize published array designs in terms of these FoMs.

In Vivo Measurement of Rat Brain Water Content at 9.4 T MR Using Super-Resolution Reconstruction: Validation With Ex Vivo Experiments.

BACKGROUND: Given that changes in brain water content are often correlated with disease, investigating water content non-invasively and in vivo could lead to a better understanding of the pathogenesis of several neurologic diseases. PURPOSE: To adapt a super-resolution-based technique, previously developed for humans, to the rat brain and report in vivo high-resolution (HR) water content maps in comparison with ex vivo wet/dry methods. STUDY TYPE: Prospective. ANIMAL MODEL: Eight healthy male Wistar rats. FIELD STRENGTH/SEQUENCE: 9.4-T, multi-echo gradient-echo (mGRE) sequence. ASSESSMENT: Using super-resolution reconstruction (SRR), a HR mGRE image (200 µm isotropic) was reconstructed from three low-resolution (LR) orthogonal whole-brain images in each animal, which was followed by water content mapping in vivo. The animals were subsequently sacrificed, the brains excised and divided into five regions (front left, front right, middle left, middle right, and cerebellum-brainstem regions), and the water content was measured ex vivo using wet/dry measurements as the reference standard. The water content values of the in vivo and ex vivo methods were then compared for the whole brain and also for the different regions separately. STATISTICAL TESTS: Friedman's non-parametric test was used to test difference between the five regions, and Pearson's correlation coefficient was used for correlation between in vivo and ex vivo measurements. A P-value <0.05 was considered statistically significant. RESULTS: Water content values derived from in vivo MR measurements showed strong correlations with water content measured ex vivo at a regional level (r = 0.902). Different brain regions showed significantly different water content values. Water content values were highest in the frontal brain, followed by the midbrain, and lowest in the cerebellum and brainstem regions. DATA CONCLUSION: An in vivo technique to achieve HR isotropic water content maps in the rat brain using SRR was adopted in this study. The MRI-derived water content values obtained using the technique showed strong correlations with water content values obtained using ex vivo wet/dry methods. LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY: Stage 1.

Design of a Folded, Double-Tuned Loop Coil for ¹H/X-Nuclei MRI Applications.

MR measurement using a combination of X-nuclei and proton MRI is of great interest as the information provided by the two nuclei is highly complementary, with the X-nuclei signal giving metabolic data relating to potential biomarkers and the proton signal affording anatomical details. Due to the relatively weak signal obtained from X-nuclei, combining an X-nuclei coil with a proton coil is also advantageous for [Formula: see text] shimming and scout images. One approach to building a double-resonant coil is to modify the coil geometry. Here, to achieve double-resonance, a 2× 1 ladder network was designed and tuned at both proton and X-nuclei frequencies successfully. Due to coupling between closed wires, the double-tuned coil generates a shifted transmit efficiency pattern compared to that of the single-tuned loop at the 7T MRI proton frequency. To compensate for the shifted pattern, one part of the 2× 1 ladder network was folded, and the tuning and performance of the folded double-tuned coil were evaluated in simulations and MR measurements. The proposed structure was further evaluated with overlapped decoupling in a receive-only array. The results show that our proposed folded double-tuned coil moderated the shifted pattern of a straight double-tuned loop coil and provided minimum losses at both proton and X-nuclei frequencies. The proposed folded double-tuned loop coil has also been further extended to a receive-only array.

B1 field map synthesis with generative deep learning used in the design of parallel-transmit RF pulses for ultra-high field MRI.

Spoke trajectory parallel transmit (pTX) excitation in ultra-high field MRI enables B1+ inhomogeneities arising from the shortened RF wavelength in biological tissue to be mitigated. To this end, current RF excitation pulse design algorithms either employ the acquisition of field maps with subsequent non-linear optimization or a universal approach applying robust pre-computed pulses. We suggest and evaluate an intermediate method that uses a subset of acquired field maps combined with generative machine learning models to reduce the pulse calibration time while offering more tailored excitation than robust pulses (RP). The possibility of employing image-to-image translation and semantic image synthesis machine learning models based on generative adversarial networks (GANs) to deduce the missing field maps is examined. Additionally, an RF pulse design that employs a predictive machine learning model to find solutions for the non-linear (two-spokes) pulse design problem is investigated. As a proof of concept, we present simulation results obtained with the suggested machine learning approaches that were trained on a limited data-set, acquired in vivo. The achieved excitation homogeneity based on a subset of half of the B1+ maps acquired in the calibration scans and half of the B1+ maps synthesized with GANs is comparable with state of the art pulse design methods when using the full set of calibration data while halving the total calibration time. By employing RP dictionaries or machine-learning RF pulse predictions, the total calibration time can be reduced significantly as these methods take only seconds or milliseconds per slice, respectively.

Test-retest stability of spontaneous brain activity and functional connectivity in the core resting-state networks assessed with ultrahigh field 7-Tesla resting-state functional magnetic resonance imaging.

The growing demand for precise and reliable biomarkers in psychiatry is fueling research interest in the hope that identifying quantifiable indicators will improve diagnoses and treatment planning across a range of mental health conditions. The individual properties of brain networks at rest have been highlighted as a possible source for such biomarkers, with the added advantage that they are relatively straightforward to obtain. However, an important prerequisite for their consideration is their reproducibility. While the reliability of resting-state (RS) measurements has often been studied at standard field strengths, they have rarely been investigated using ultrahigh-field (UHF) magnetic resonance imaging (MRI) systems. We investigated the intersession stability of four functional MRI RS parameters-amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; representing the spontaneous brain activity), regional homogeneity (ReHo; measure of local connectivity), and degree centrality (DC; measure of long-range connectivity)-in three RS networks, previously shown to play an important role in several psychiatric diseases-the default mode network (DMN), the central executive network (CEN), and the salience network (SN). Our investigation at individual subject space revealed a strong stability for ALFF, ReHo, and DC in all three networks, and a moderate level of stability in fALFF. Furthermore, the internetwork connectivity between each network pair was strongly stable between CEN/SN and moderately stable between DMN/SN and DMN/SN. The high degree of reliability and reproducibility in capturing the properties of the three major RS networks by means of UHF-MRI points to its applicability as a potentially useful tool in the search for disease-relevant biomarkers.

A Novel J-Shape Antenna Array for Simultaneous MR-PET or MR-SPECT Imaging.

Simultaneous MR-PET/-SPECT is an emerging technology that capitalises on the invaluable advantages of both modalities, allowing access to numerous sensitive tracers and superior soft-tissue contrast alongside versatile functional imaging capabilities. However, to optimise these capabilities, concurrent acquisitions require the MRI antenna located inside the PET/SPECT field-of-view to be operated without compromising any aspects of system performance or image quality compared to the stand-alone instrumentation. Here, we report a novel gamma-radiation-transparent antenna concept. The end-fed J-shape antenna is particularly adept for hybrid ultra-high field MR-PET/-SPECT applications as it enables all highly attenuating materials to be placed outside the imaging field-of-view. Furthermore, this unique configuration also provides advantages in stand-alone MR applications by reducing the amount of coupling between the cables and the antenna elements, and by lowering the potential specific absorption rate burden. The use of this new design was experimentally verified according to the important features for both ultra-high field MRI and the 511 keV transmission scan. The reconstructed attenuation maps evidently showed much lower attenuation (  âˆ¼ 15 %) for the proposed array when compared to the conventional dipole antenna array since there were no high-density components. In MR, it was observed that the signal-to-noise ratio from the whole volume obtained using the proposed array was comparable to that acquired by the conventional array which was also in agreement with the simulation results. The unique feature, J-shape array, would enable simultaneous MR-PET/-SPECT experiments to be conducted without unduly compromising any aspects of system performance and image quality compared to the stand-alone instrumentation.

MRI Coil Development Strategies for Hybrid MR-PET Systems: A Review.

Simultaneously operating MR-PET systems have the potential to provide synergetic multi-parametric information, and, as such, interest surrounding their use and development is increasing. However, despite the potential advantages offered by fully combined MR-PET systems, implementing this hybrid integration is technically laborious, and any factors degrading the quality of either modality must be circumvented to ensure optimal performance. In order to attain the best possible quality from both systems, most full MR-PET integrations tend to place the shielded PET system inside the MRI system, close to the target volume of the subject. The radiofrequency (RF) coil used in MRI systems is a key factor in determining the quality of the MR images, and, in simultaneous acquisition, it is generally positioned inside the PET system and PET imaging region, potentially resulting in attenuation and artefacts in the PET images. Therefore, when designing hybrid MR-PET systems, it is imperative that consideration be given to the RF coils inside the PET system. In this review, we present current state-of-the-art RF coil designs used for hybrid MR-PET experiments and discuss various design strategies for constructing PET transparent RF coils.

Design and Construction of a PET-Compatible Double-Tuned 1H/31P MR Head Coil.

Simultaneous MR-PET is an increasingly popular multimodal imaging technique that is able to combine metabolic information obtained from PET with anatomical/functional information from MRI. One of the key technological challenges of the technique is the integration of a PET-transparent MR coil system, a solution to which is demonstrated here for a double-tuned 1H/31P head coil at 3 T. Two single-resonant birdcage coils tuned to the 1H and 31P resonances were arranged in an interleaved fashion and electrically decoupled with the use of trap circuits. All high 511 keV quanta absorbing components were arranged outside the PET field-of-view in order to minimize count rate reduction. The materials inside the PET field-of-view were carefully evaluated and chosen for minimum impact on the PET image quality. As far as possible, the coil case was geometrically optimized to avoid sharp transitions in attenuation, which may potentially result in streaking artefacts during PET image reconstruction. The coil caused a count rate loss of just above 5% when inserted into the PET detector ring. Except for the anterior region, which was designed to maintain free openings for increased patient comfort, an almost uniform distribution of 511 keV attenuation was maintained around the circumference of the coil. MR-related performance for both nuclei was similar or slightly better than that of a commercial double-tuned coil, despite the MR-PET coil having a close-fitting RF screen to shield the PET and MR electronics from possible electromagnetic interferences.

The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla.

OBJECT: This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for quantitative brain imaging. MATERIAL AND METHODS: Two subjects - termed the "traveling heads" - were imaged at ten different 7 T sites with a harmonized quantitative brain MR imaging protocol. In conjunction with the system calibration, MP2RAGE, QSM, CEST and multi-parametric mapping/relaxometry were examined. RESULTS: Quantitative measurements with MP2RAGE showed very high reproducibility across sites and subjects, and errors were in concordance with previous results and other field strengths. QSM had high inter-site reproducibility for relevant subcortical volumes. CEST imaging revealed systematic differences between the sites, but reproducibility was comparable to results in the literature. Relaxometry had also very high agreement between sites, but due to the high sensitivity, differences caused by different applications of the B1 calibration of the two RF coil types used were observed. CONCLUSION: Our results show that quantitative brain imaging can be performed with high reproducibility at 7 T and with similar reliability as found at 3 T for multicenter studies of the supratentorial brain.

Efficient eddy current characterization using a 2D image-based sampling scheme and a model-based fitting approach.

PURPOSE: To propose two innovations to existing eddy current characterization techniques, which include (1) an efficient spatio-temporal sampling scheme and (2) a model-based fitting of spherical harmonic eddy current components. THEORY AND METHODS: This work introduces a three-plane 2D image-based acquisition scheme to efficiently sample eddy current fields. Additionally, a model-based spherical harmonic decomposition is presented, which reduces fitting noise using a rank minimization to impose an exponential decay on the eddy current amplitude evolution. Both techniques are applied in combination and analyzed in simulations for their applicability in reconstructing suitable pre-emphasis parameters. In a proof-of-concept measurement, the routine is tested for its propriety to correctly quantify user-defined field dynamics. Furthermore, based on acquired precompensation and postcompensation eddy current data, the suitability of pre-emphasis parameters calculated based on the proposed technique is evaluated. RESULTS: Simulation results derived from 500 data sets demonstrate the applicability of the acquisition scheme for the spatio-temporal sampling of eddy current fields. Compared with a conventional data processing strategy, the proposed model-based approach yields pre-emphasis parameters that reduce the average maximum residual field offset within a 10-cm-diameter spherical volume from 3.17 Hz to 0.58 Hz. Experimental data prove the proposed routine to be suitable to measure and effectively compensate for eddy currents within 10 minutes of acquisition time. CONCLUSION: The proposed framework was found to be well-suited to efficiently characterize and compensate for eddy current fields in a one-time calibration effort. It can be applied to facilitate pre-emphasis implementations, such as for dynamic B0 shimming applications.

Optimization of high-channel count, switch matrices for multinuclear, high-field MRI.

Modern magnetic resonance imaging systems are equipped with a large number of receive connectors in order to optimally support a large field-of-view and/or high acceleration in parallel imaging using high-channel count, phased array coils. Given that the MR system is equipped with a limited number of digitizing receivers and in order to support operation of multinuclear coil arrays, these connectors need to be flexibly routed to the receiver outside the RF shielded examination room. However, for a number of practical, economic and safety reasons, it is better to only route a subset of the connectors. This is usually accomplished with the use of switch matrices. These exist in a variety of topologies and differ in routing flexibility and technological implementation. A highly flexible implementation is a crossbar topology that allows to any one input to be routed to any one output and can use single PIN diodes as active elements. However, in this configuration, long open-ended transmission lines can potentially remain connected to the signal path leading to high transmission losses. Thus, especially for high-field systems compensation mechanisms are required to remove the effects of open-ended transmission line stubs. The selection of a limited number of lumped element reactance values to compensate for the for the effect of transmission line stubs in large-scale switch matrices capable of supporting multi-nuclear operation is non-trivial and is a combinatorial problem of high order. Here, we demonstrate the use of metaheuristic approaches to optimize the circuit design of these matrices that additionally carry out the optimization of distances between the parallel transmission lines. For a matrix with 128 inputs and 64 outputs a realization is proposed that displays a worst-case insertion loss of 3.8 dB.

Application of Evolution Strategies to the Design of SAR Efficient Parallel Transmit Multi-Spoke Pulses for Ultra-High Field MRI.

We present an evolution-strategy based approach to solve the magnitude least squares (MLS) design problem of low flip-angle slice-selective parallel transmit RF pulses for ultra-high field MRI using SAR and peak-RF-constraints. A combined transmit k-space trajectory and RF pulse weight optimization is proposed in two algorithmic steps. The first step is a coarse grid search to find an initial solution that fulfills all constraints for the subsequent multistage optimization. This avoids convergence to the next nearest local minimum. The second step attempts to refine the results using multiple evolution strategies. We compare the performance of our approach with the non-convex optimization methods described in the literature. The proposed algorithm converges for phantom and in vivo data and only requires an initial estimate of the range of suitable regularization parameters. It demonstrates improved excitation homogeneity compared to published spoke-design methods and allows optimization for homogeneity with a subsequent reduction in the SAR burden. Moreover, excitation homogeneity and the SAR burden can be balanced against each other, enabling a further reduction in SAR at the cost of minor relaxations in excitation homogeneity. This feature makes the algorithm a good candidate for SAR limited sequences in ultra-high field imaging. The algorithm is validated using phantom and in vivo measurements obtained with a 16-channel transmit array at 9.4T.

An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems.

BACKGROUND: In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters. By then combining this technique with PET, which provides valuable insight into a wide range of metabolic and molecular processes by using of a variety of radioactive tracers, the scope of medical imaging and diagnostics can be significantly increased. While the use of multimodal imaging is undoubtedly advantageous, identifying the optimal combination of these parameters to diagnose a specific dysfunction is very important and is advanced by the use of sophisticated imaging techniques in specific animal models. METHODS: In this pilot study, rats with intracerebral 9L gliosarcomas were used to explore a combination of sequential multinuclear MRI using a sophisticated switchable coil set in a small animal 9.4 T MRI scanner and, subsequently, a small animal PET with the tumour tracer O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET). This made it possible for in vivo multinuclear MR-PET experiments to be conducted without compromising the performance of either multinuclear MR or PET. RESULTS: High-quality in vivo images and spectra including high-resolution 1H imaging, 23Na-weighted imaging, detection of 31P metabolites and [18F]FET uptake were obtained, allowing the characterisation of tumour tissues in comparison to a healthy brain. It has been reported in the literature that these parameters are useful in the identification of the genetic profile of gliomas, particularly concerning the mutation of the isocitrate hydrogenase gene, which is highly relevant for treatment strategy. CONCLUSIONS: The combination of multinuclear MR and PET in, for example, brain tumour models with specific genetic mutations will enable the physiological background of signal alterations to be explored and the identification of the optimal combination of imaging parameters for the non-invasive characterisation of the molecular profile of tumours.

The state-of-the-art and emerging design approaches of double-tuned RF coils for X-nuclei, brain MR imaging and spectroscopy: A review.

With the increasing availability of ultra-high field MRI systems, studying non-proton nuclei (X-nuclei), such as 23Na and 31P has received great interest. X-nuclei are able to provide insight into important cellular processes and energy metabolism in tissues and by monitoring these nuclei closely it is possible to establish links to pathological conditions and neurodegenerative diseases. In order to investigate X-nuclei, a well-designed radiofrequency (RF) system with a multi-tuned RF coil is required. However, as the intrinsic sensitivity of non-proton nuclei is lower compared to 1H, it is important to ensure that the signal-to-noise ratio (SNR) of the X-nuclei is as high as possible. This review aims to give a comprehensive overview of previous efforts, with particular focus on the design concept of multi-tuned coils, predominantly for brain applications. In order to guide the readers, the main body of the review is categorised into two parts: state-of-the art according to the single or multiple design structures and emerging technologies. A more detailed description is given in each subsection relating to the specific design approaches of, mostly, double-tuned coils, including using traps, PIN-diodes, nested and metamaterial, together with explanations of their novelties, optimal solutions and trade-offs.

Design, evaluation and comparison of endorectal coils for hybrid MR-PET imaging of the prostate.

Prostate cancer is one of the most common cancers among men and its early detection is critical for its successful treatment. The use of multimodal imaging, such as MR-PET, is most advantageous as it is able to provide detailed information about the prostate. However, as the human prostate is flexible and can move into different positions under external conditions, it is important to localise the focused region-of-interest using both MRI and PET under identical circumstances. In this work, we designed five commonly used linear and quadrature radiofrequency surface coils suitable for hybrid MR-PET use in endorectal applications. Due to the endorectal design and the shielded PET insert, the outer face of the coils investigated was curved and the region to be imaged was outside the volume of the coil. The tilting angles of the coils were varied with respect to the main magnetic field direction. This was done to approximate the various positions from which the prostate could be imaged. The transmit efficiencies and safety excitation efficiencies from simulations, together with the signal-to-noise ratios from the MR images were calculated and analysed. Overall, it was found that the overlapped loops driven in quadrature were superior to the other types of coils we tested. In order to determine the effect of the different coil designs on PET, transmission scans were carried out, and it was observed that the differences between attenuation maps with and without the coils were negligible. The findings of this work can provide useful guidance for the integration of such coil designs into MR-PET hybrid systems in the future.

Interslice current change constrained B0 shim optimization for accurate high-order dynamic shim updating with strongly reduced eddy currents.

PURPOSE: To overcome existing challenges in dynamic B0 shimming by implementing a shim optimization algorithm which limits shim current amplitudes and their temporal variation through the application of constraints and regularization terms. THEORY AND METHODS: Spherical harmonic dynamic B0 shimming is complicated by eddy currents, ill-posed optimizations, and the need for strong power supplies. Based on the fact that eddy current amplitudes are proportional to the magnitude of the shim current changes, and assuming a smoothness of the B0 inhomogeneity variation in the slice direction, a novel algorithm was implemented to reduce eddy current generation by limiting interslice shim current changes. Shim degeneracy issues and resulting high current amplitudes are additionally addressed by penalizing high solution norms. Applicability of the proposed algorithm was validated in simulations and in phantom and in vivo measurements. RESULTS: High-order dynamic shimming simulations and measurements have shown that absolute shim current amplitudes and their temporal variation can be substantially reduced with negligible loss in achievable B0 homogeneity. Whereas conventional dynamic shim updating optimizations improve the B0 homogeneity, on average, by a factor of 2.1 over second-order static solutions, our proposed routine reached a factor of 2.0, while simultaneously providing a 14-fold reduction of the average maximum shim current changes. CONCLUSIONS: The proposed algorithm substantially reduces the shim amplitudes and their temporal variation, while only marginally affecting the achievable B0  homogeneity. As a result, it has the potential to mitigate the remaining challenges in dynamic B0 shimming and help in making its application more readily available.

Design and evaluation of a 1H/31P double-resonant helmet coil for 3T MRI of the brain.

Proton magnetic resonance imaging (MRI) can be combined with signals from non-proton nuclei (X-nuclei) to provide metabolic information. Double-resonant coils are often used for X-nuclei MR studies where the proton element is employed for scout imaging and B 0 shimming. This work describes the development of a new double-resonant coil capable of operating at both proton and X-nuclei frequencies. The proposed design extends the wheel-and-spoke coil, which allows for quadrature drive, by adding an extra ring outside the coil to achieve double-resonance. Furthermore, in order to maximise SNR by increasing the filling factor, the shape of the coil has been modified to a helmet style making it suitable for brain applications. The performance of the double-resonant helmet coil was evaluated by simulation and MR measurements. The helmet coil was successfully tuned to the 1H/31P resonance frequencies of a 3T MR scanner, with high isolation between the two quadrature ports. MR measurements of a phantom were carried out, and the averaged sensitivity of the double-resonant helmet coil over the whole phantom was found to be higher than that of the conventional double-tuned birdcage coil at both frequencies.

MR-compatible, 3.8 inch dual organic light-emitting diode (OLED) in-bore display for functional MRI.

PURPOSE: Functional MRI (fMRI) is a well-established method used to investigate localised brain activation by virtue of the blood oxygen level dependent (BOLD) effect. It often relies on visual presentations using beam projectors, liquid crystal display (LCD) screens, and goggle systems. In this study, we designed an MR compatible, low-cost display unit based on organic light-emitting diodes (OLED) and demonstrated its performance. METHODS: A 3.8" dual OLED module and an MIPI-to-HDMI converter board were used. The OLED module was enclosed using a shielded box to prevent noise emission from the display module and the potentially destructive absorption of high power RF from the MRI transmit pulses. The front of the OLED module was covered by a conductive, transparent mesh. Power was supplied from a non-magnetic battery. The shielding of the display was evaluated by directly measuring the electromagnetic emission with the aid of a pickup loop and a low noise amplifier, as well as by examining the signal-to-noise ratio (SNR) of phantom MRI data. The visual angle of the display was calculated and compared to standard solutions. As a proof of concept of the OLED display for fMRI, a healthy volunteer was presented with a visual block paradigm. RESULTS: The OLED unit was successfully installed inside a 3 T MRI scanner bore. Operation of the OLED unit did not degrade the SNR of the phantom images. The fMRI data suggest that visual stimulation can be effectively delivered to subjects with the proposed OLED unit without any significant interference between the MRI acquisitions and the display module itself. DISCUSSION: We have constructed and evaluated the MR compatible, dual OLED display for fMRI studies. The proposed OLED display provides the benefits of high resolution, wide visual angle, and high contrast video images during fMRI exams.

Signal Loss Compensation of RF Crossbar Switch Matrix System in Ultra-High Field MRI.

With the increased commercial availability of high channel count MR coil arrays and the associated higher number of plugs in the patient bed, it has become a common practice to include switch matrices in the receive path of MR systems. These allow the arbitrary routing of a signal from any plug to any receiver in the console. While switch matrices are standard in systems at clinical field strength and have been developed for systems operating up to 4T, they have not yet been implemented at ultra-high field (UHF). Here, we present a switch matrix suitable for operation at UHF. Crossbar switches, which are the most frequently employed forms of a switch matrix, use RF switches to connect horizontal input lines with the desired vertical output line. This leaves transmission line stubs of variable length physically connected with the selected signal path, potentially resulting in elevated signal losses. While this can be tolerated at low frequencies, and only needs partial compensation at intermediate frequencies (4T), a full compensation is required at UHF. In this study, an RF crossbar switch, which uses switchable compensation elements in both horizontal and vertical transmission lines, was implemented for a 9.4T MRI scanner. The prototype developed was evaluated for single channel and multichannel receive performance and benchmarked against a fixed wire connection.

Design and use of a folded four-ring double-tuned birdcage coil for rat brain sodium imaging at 9.4 T.

A folded four-ring quadrature birdcage coil was designed and constructed with a double-tune configuration of an outer high-pass coil for 1H (400 MHz) and inner low-pass coil for 23Na (105.72 MHz at 9.4 T). The coil was evaluated on the bench and in the scanner, comparing its performance with that of single-tuned coils and a large four-ring coil. All coils were tuned and matched and the isolation between two quadrature ports was found to be better than -13.7 dB for 1H and -27 dB for 23Na. Signal-to-noise ratios (SNRs) were calculated and 23Na flip angle maps were acquired. 23Na SNR of the folded four-ring reached ∼93% of that obtained with the single-tuned coil. A set of in vivo1H and 23Na axial images to cover the whole rat brain were obtained. The performance of the folded four-ring coil and its benefit for 23Na imaging experiments have been demonstrated. This proposed four-ring coil could avoid length restrictions, e.g. the shoulders, by folding the outer rings vertically. This facilitates the construction of double-tuned four-ring birdcage coils just to fit the head, leading to higher filling factors and better SNR.