ABSTRACT
Persistent sciatic artery (PSA) is a rare vascular anomaly that results from failure of an embryonal artery to the lower extremities to regress during fetal development. Aneurysm formation, thromboembolism, and arterial occlusions may complicate this abnormality. We report a patient with complete bilateral PSA and intermittent claudication who was treated by bilateral percutaneous angioplasty.
Subject(s)
Angioplasty, Balloon , Arteries/abnormalities , Intermittent Claudication/therapy , Leg/blood supply , Angiography , Humans , Intermittent Claudication/complications , Intermittent Claudication/diagnostic imaging , Male , Middle AgedABSTRACT
Assays for phosphotyrosyl protein phosphatase activity have been developed using the synthetic peptide Glu-Glu-Tyr(P)-Ala-Ala and its N alpha-fluorenylmethoxycarbonyl derivative (Fmoc-Glu-Glu-Tyr(P)-Ala-Ala) as substrates. Conditions for monitoring the phosphatase-catalyzed hydrolysis of the former peptide, either spectrophotometrically or fluorometrically, are reported. These continuous assays are similar in sensitivity to published assays using phosphotyrosine as substrate. A discontinuous HPLC-based assay using the intensely fluorescent Fmoc-peptide as substrate is also described. This assay is comparable in sensitivity to assays using 32P-labeled substrates and is suitable for assaying low levels of phosphotyrosyl protein phosphatase activity in crude tissue extracts.
Subject(s)
Fluorenes/metabolism , Oligopeptides/metabolism , Phosphopeptides/metabolism , Protein Tyrosine Phosphatases/metabolism , Amino Acid Sequence , Animals , Chromatography, High Pressure Liquid , Kinetics , Mice , Molecular Sequence Data , Spectrometry, Fluorescence , Tyrosine/metabolismABSTRACT
The angiographic, phlebographic and lymphographic findings in a 3-year old girl with mixed angiodysplasia (Klippel-Trenaunay-Weber syndrome) combined with unilateral congenital choanal atresia are described.
Subject(s)
Abnormalities, Multiple/diagnostic imaging , Angiomatosis/complications , Klippel-Trenaunay-Weber Syndrome/complications , Nasal Cavity/abnormalities , Nasopharynx/abnormalities , Nose Deformities, Acquired , Angiography , Gigantism/complications , Humans , Leg/blood supply , Lymphatic System/abnormalities , Lymphography , Male , Pelvis , PhlebographyABSTRACT
The rare condition Vrolik's syndrome and its typical radiological signs are described with reference to two cases.
