Emoji use validates the potential for meaning standardization among ideographic symbols.

Technological innovations for online communication reduce the impact of signal transience on meaning standardization while boosting access to reliable patterning across multiple linguistic and nonlinguistic contexts - both asynchronous and synchronous. We classify emojis as ideographic symbols, examine their interdependence with surrounding words when reading/writing, and argue that emoji use validates the potential for meaning standardization in ideographs.

Are emojis processed like words?: Eye movements reveal the time course of semantic processing for emojified text.

Emojis have many functions that support reading. Most obviously, they convey semantic information and support reading comprehension (Lo, CyberPsychology & Behavior, 11[5], 595-597, 2008; Riordan, Computers in Human Behavior, 76, 75-86, 2017b). However, it is undetermined whether emojis recruit the same perceptual and cognitive processes for identification and integration during reading as do words. To investigate whether emojis are processed like words, we used eye tracking to examine the time course of semantic processing of emojis during reading. Materials consisted of sentences containing a target word (e.g., coffee in the sentence "My tall coffee is just the right temperature") when there was no emoji present and when there was a semantically congruent (i.e., synonymous) emoji (e.g., the cup of coffee emoji, ) or an incongruent emoji (e.g., the beer mug emoji, ) present at the end of the sentence. Similar to congruency effects with words, congruent emojis were fixated for shorter periods and were less likely to be refixated than were incongruent emojis. In addition, congruent emojis were more frequently skipped than incongruent emojis, which suggests that semantic aspects of emoji processing begin in the parafovea. Finally, the presence of an emoji, relative to its absence increased target-word skipping rates and reduced total time on target words. We discuss the implications of our findings for models of eye-movement control during reading.

The dynamics of negative stereotypes as revealed by tweeting behavior in the aftermath of the Charlie Hebdo terrorist attack.

We describe the evolution of a stereotype as it emerged in tweets about the Charlie Hebdo terrorist attack in Paris in early 2015. Our focus is on terms associated with the Muslim community and the Islamic world. The data (400k tweets) were collected via Twitter streaming API and consisted of tweets that contained at least one of 16 hashtags associated with the Charlie Hebdo attack (e.g., #JeSuisCharlie, #IAmCharlie, #ParisAttacks), collected between January 14th and February 9th. From these data, we generated pairwise co-occurrence frequencies between key words such as "Islam", "Muslim(s)", "Arab(s)", and "The Prophet" and possible associates such as: "terrorism", "terror", "terrorist(s)", "kill(ed)", "free", "freedom" and "love". We use changes in frequency of co-occurring words to define ways in which acute negative and positive stereotypes towards Muslims and Islam arise and evolve in three phases during the period of interest. We identify a positively-valenced backlash in a subset of tweets associated with the "origins of Islam". Results depict the emergence and transformation of implicit online stereotypes related to Islam from naturally occurring social media data and how pro-as well as anti-Islam online small-world networks evolve in response to a terrorist attack.

Discrimination in lexical decision.

In this study we present a novel set of discrimination-based indicators of language processing derived from Naive Discriminative Learning (ndl) theory. We compare the effectiveness of these new measures with classical lexical-distributional measures-in particular, frequency counts and form similarity measures-to predict lexical decision latencies when a complete morphological segmentation of masked primes is or is not possible. Data derive from a re-analysis of a large subset of decision latencies from the English Lexicon Project, as well as from the results of two new masked priming studies. Results demonstrate the superiority of discrimination-based predictors over lexical-distributional predictors alone, across both the simple and primed lexical decision tasks. Comparable priming after masked corner and cornea type primes, across two experiments, fails to support early obligatory segmentation into morphemes as predicted by the morpho-orthographic account of reading. Results fit well with ndl theory, which, in conformity with Word and Paradigm theory, rejects the morpheme as a relevant unit of analysis. Furthermore, results indicate that readers with greater spelling proficiency and larger vocabularies make better use of orthographic priors and handle lexical competition more efficiently.

Emoticons in text may function like gestures in spoken or signed communication.

We draw parallels between emoticons in textual communication and gesture in signed language with respect to the interdependence of codes by describing two contexts under which the behavior of emoticons in textual communication resembles that of gesture in speech. Generalizing from those findings, we propose that gesture is likely characterized by a nuanced interdependence with language whether signed, spoken or texted.

If priming is graded rather than all-or-none, can reactivating abstract structures be the underlying mechanism?

In our commentary on Branigan & Pickering (B&P), we start by arguing that the authors implicitly adopt several assumptions, the consequence of which is to make further claims necessary and/or sufficient. Crucially, the authors assume the existence of discrete units at various levels of linguistic granularity that then must be operated upon by combinatorial mechanisms and rules (i.e., decomposition/recomposition). They further argue that structural priming provides a powerful tool to study abstract, structural representations. We provide evidence that priming effects in production are characterized better as graded than as all-or-none and that priming need not arise from a mechanism that (re)activates a shared but abstract internal structure.

Perception, as you make it.

The main question that Firestone & Scholl (F&S) pose is whether "what and how we see is functionally independent from what and how we think, know, desire, act, and so forth" (sect. 2, para. 1). We synthesize a collection of concerns from an interdisciplinary set of coauthors regarding F&S's assumptions and appeals to intuition, resulting in their treatment of visual perception as context-free.

Must analysis of meaning follow analysis of form? A time course analysis.

Many models of word recognition assume that processing proceeds sequentially from analysis of form to analysis of meaning. In the context of morphological processing, this implies that morphemes are processed as units of form prior to any influence of their meanings. Some interpret the apparent absence of differences in recognition latencies to targets (SNEAK) in form and semantically similar (sneaky-SNEAK) and in form similar and semantically dissimilar (sneaker-SNEAK) prime contexts at a stimulus onset asynchrony (SOA) of 48 ms as consistent with this claim. To determine the time course over which degree of semantic similarity between morphologically structured primes and their targets influences recognition in the forward masked priming variant of the lexical decision paradigm, we compared facilitation for the same targets after semantically similar and dissimilar primes across a range of SOAs (34-100 ms). The effect of shared semantics on recognition latency increased linearly with SOA when long SOAs were intermixed (Experiments 1A and 1B) and latencies were significantly faster after semantically similar than dissimilar primes at homogeneous SOAs of 48 ms (Experiment 2) and 34 ms (Experiment 3). Results limit the scope of form-then-semantics models of recognition and demonstrate that semantics influences even the very early stages of recognition. Finally, once general performance across trials has been accounted for, we fail to provide evidence for individual differences in morphological processing that can be linked to measures of reading proficiency.

Human selenium binding protein-1 (hSP56) is a negative regulator of HIF-1α and suppresses the malignant characteristics of prostate cancer cells.

In the present study, we demonstrate that ectopic expression of 56-kDa human selenium binding protein-1 (hSP56) in PC-3 cells that do not normally express hSP56 results in a marked inhibition of cell growth in vitro and in vivo. Down-regulation of hSP56 in LNCaP cells that normally express hSP56 results in enhanced anchorage-independent growth. PC-3 cells expressing hSP56 exhibit a significant reduction of hypoxia inducible protein (HIF)-1α protein levels under hypoxic conditions without altering HIF-1α mRNA (HIF1A) levels. Taken together, our findings strongly suggest that hSP56 plays a critical role in prostate cells by mechanisms including negative regulation of HIF-1α, thus identifying hSP56 as a candidate anti-oncogene product.

Does a focus on universals represent a new trend in word recognition?

Comparisons across languages have long been a means to investigate universal properties of the cognitive system. Although differences between languages may be salient, it is the underlying similarities that have advanced our understanding of language processing. Frost is not unique in emphasizing that the interaction among linguistic codes reinforces the inadequacy of constructing a model of word recognition where orthographic processes operate in isolation.

Semantic similarity influences early morphological priming in Serbian: a challenge to form-then-meaning accounts of word recognition.

Semantically similar (e.g., coolant-COOL) primes have produced greater facilitation than have form-similar but semantically dissimilar (e.g., rampant-RAMP) primes when English words have appeared in the forward-masked primed lexical decision task (Feldman, O'Connor, & Moscoso del Prado Martín, Psychonomic Bulletin & Review 16: 684-691, 2009). These results challenge claims that form-based, semantically blind activation underlies early morphological facilitation. Some have argued that the English materials in previous studies were not ideally constructed, insofar as the types of spelling changes to affixed stems differed in the semantically similar and dissimilar pairs. The present study exploited Serbian's bialphabetism, rich morphology, and homographic (form-identical) stems to replicate early effects of semantic similarity. Furthermore, it incorporated within-target manipulations of prime type and of alphabet, such that the alphabets of the prime-target pairs matched in Experiment 1a and alternated in Experiment 1b. Importantly, no letter or phoneme changes occurred between the stems of the primes and targets. These results revealed significant effects of semantic similarity that are comparable with and without alphabet alternation. The semantic effects in Serbian replicated almost exactly those in English (Feldman et al., Psychonomic Bulletin & Review 16: 684-691, 2009), which suggests that even early in the course of processing, morphemes are units of meaning as well as of form. The results failed to support models of lexical processing that postulate sequential access, first to the morphological form, and then to the semantic aspects of words.

Morphological facilitation for regular and irregular verb formations in native and non-native speakers: Little evidence for two distinct mechanisms.

The authors compared performance on two variants of the primed lexical decision task to investigate morphological processing in native and non-native speakers of English. They examined patterns of facilitation on present tense targets. Primes were regular (billed-bill) past tense formations and two types of irregular past tense forms that varied on preservation of target length (fell-fall; taught-teach). When a forward mask preceded the prime (Exp. 1), language and prime type interacted. Native speakers showed reliable regular and irregular length preserved facilitation relative to orthographic controls. Non-native speakers' latencies after morphological and orthographic primes did not differ reliably except for regulars. Under cross-modal conditions (Exp. 2), language and prime type interacted. Native but not non-native speakers showed inhibition following orthographically similar primes. Collectively, reliable facilitation for regulars and patterns across verb type and task provided little support for a processing dichotomy (decomposition, non-combinatorial association) based on inflectional regularity in either native or non-native speakers of English.

The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells From clinic to bench - a critical review.

Recombinant human erythropoietin (rhEPO) has been used clinically to alleviate cancer- and chemotherapy-related anemia. However, recent clinical trials have reported that rhEPO also may adversely impact disease progression and survival. The expression of functional EPO receptors (EPOR) has been demonstrated in many human cancer cells where, at least in vitro, rhEPO can stimulate cell growth and survival and may induce resistance to selected therapies. Responses to rhEPO measured by alterations in tumor cell growth or survival, activation of signaling pathways or modulation of sensitivity to anticancer agents are variable. Both methodological and inherent biological issues underlie the differential cell responses, including reported difficulties in EPOR protein detection, potential involvement of EPOR isoforms or of cytoplasmic EPOR, possible differential structure and/or binding affinities of hematopoietic versus non-hematopoietic cell EPOR, possible aberrant regulation of EPOR activity, and a functional EPO/EPOR autocrine/paracrine loop. The modulation by rhEPO of tumor cell response to anticancer agents is coincident with modulation of multiple signaling pathways, BCL-2 family proteins, caspases and NFkB. The molecular interplay of pro-survival and pro-death signals, triggered by EPO and/or by anticancer agents, is multifactorial and tightly coordinated. Expression microarray analysis may prove critical for deciphering this potentially novel network and its broad spectrum of genes and proteins.

Early morphological processing is morphosemantic and not simply morpho-orthographic: a violation of form-then-meaning accounts of word recognition.

Many studies have suggested that a word's orthographic form must be processed before its meaning becomes available. Some interpret the (null) finding of equal facilitation after semantically transparent and opaque morphologically related primes in early stages of morphological processing as consistent with this view. Recent literature suggests that morphological facilitation tends to be greater after transparent than after opaque primes, however. To determine whether the degree of semantic transparency influences parsing into a stem and a suffix (morphological decomposition) in the forward masked priming variant of the lexical decision paradigm, we compared patterns of facilitation between semantically transparent (e.g., coolant-cool) and opaque (e.g., rampant-ramp) prime-target pairs. Form properties of the stem (frequency, neighborhood size, and prime-target letter overlap), as well as related-unrelated and transparent-opaque affixes, were matched. Morphological facilitation was significantly greater for semantically transparent pairs than for opaque pairs. Ratings of prime-target relatedness predicted the magnitude of facilitation. The results limit the scope of form-then-meaning models of word recognition and demonstrate that semantic similarity can influence even early stages of morphological processing.

An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells.

Erythropoietin receptors have been identified on a variety of cancer-derived cell lines and primary cancer cells, including those of prostate cancer. The functional status of these extrahematopoietic erythropoietin receptors remains a matter of some dispute. The publication of several important clinical trials suggesting a direct effect of erythropoietin on the growth and survival of primary tumors adds further importance to the question of whether erythropoietin receptors on cancer cells are functional. We have reported previously that human prostate cancer cell lines and primary prostate cancer cells express functional erythropoietin receptors that respond to exogenous erythropoietin by increased cell proliferation and STAT5 phosphorylation. We now show that prostate cancer cell lines express both the EPO gene and the biologically active erythropoietin. The coexpression of functional receptor and biologically active ligand in the cells has led us to hypothesize an autocrine/paracrine mechanism, driven by endogenous erythropoietin, which may modulate the growth and progression of prostate cancer. To test our hypothesis, we have knocked down, independently, erythropoietin receptor and erythropoietin on prostate cancer cells by transfection with short hairpin RNAs. Erythropoietin receptor knockdown cells grow significantly more slowly than their erythropoietin receptor-bearing counterparts in monolayer culture, produce fewer, smaller colonies in soft agar, and do not exhibit erythropoietin-induced signaling. Erythropoietin knockdown cells exhibit dramatically slower rates of growth, which could be restored by transfecting the cells with a murine erythropoietin gene. Taken together, our data suggest that the coordinated regulation of a functional erythropoietin/erythropoietin receptor axis in prostate cancer cells may be integral to the growth and progression of prostate cancer.

Multiple dimensions of relatedness among words: Conjoint effects of form and meaning in word recognition.

Words can be similar with respect to form (viz., spelling, pronunciation), meaning, or both form and meaning. In three lexical decision experiments (48 ms forward masked, 116 ms, and 250 ms SOAs), targets (e.g., FLOAT) followed prime words related by form only (e.g., COAT), meaning only (e.g., SWIM), or form and meaning (e.g., BOAT). BOAT-FLOAT and SWIM-FLOAT type pairs showed reduced target decision latencies relative to unrelated controls when primes were unmasked, but not when they were masked, and the magnitude of facilitation increased with increasing prime duration. By contrast, COAT-FLOAT type pairs produced significant inhibition at the shorter two prime durations. In all three experiments, including at the shortest SOA, (BOAT-FLOAT) pairs that shared form and meaning differed from COAT-FLOAT type pairs that shared only form. We discuss the similarity of the BOAT-FLOAT pattern to that of morphological facilitation and argue that if the same mechanism underlies both outcomes then activation of a shared morphemic representation need not underlie morphological facilitation.

List context fosters semantic processing: parallels between semantic and morphological facilitation when primes are forward masked.

The authors examined patterns of facilitation under forward-masked priming conditions across 3 list contexts (Experiments 1-3) that varied with respect to properties of filler trials -- (a) mixed (morphological, orthographic, semantic), (b) identity, and (c) semantic -- but held the relatedness proportion constant (75%). Facilitation for targets that were related morphologically to their prime occurred regardless of filler context, but facilitation for semantically related pairs occurred only in the context of identity and semantic fillers. Facilitation was absent for orthographically similar prime-target pairs in all 3 filler contexts when matching numbers of orthographically similar word-word and word-nonword prime-target pairs rendered orthographic similarity uninformative with respect to lexicality of the target. Enhanced semantic and morphological facilitation in the context of identity and semantic relative to mixed fillers support a semantically attuned, as contrasted with a purely form-based, account of early morphological processing.

Erythropoietin treatment of human ovarian cancer cells results in enhanced signaling and a paclitaxel-resistant phenotype.

Erythropoietin (Epo), a glycoprotein hormone that is the principal regulator of erythropoiesis, is known to act also on nonhematopoietic cell types. Epo receptors have been reported on several normal and neoplastic human cells and tissues, including ovarian cancer cells. We found that long-term Epo treatment of A2780 cells resulted in the development of a phenotype exhibiting both enhanced Epo signaling, evidenced by increased peak levels of phospho-Erk1/2 and increased paclitaxel resistance. This phenotypic effect was specific for paclitaxel, since no change in cisplatin or carboplatin sensitivity was observed. In addition, the change in phenotype was stable, even after the removal of Epo. Measurement of mono- and oligonucleosome formation revealed that long-term Epo treated A2780 cells exhibited markedly less apoptosis than nonerythropoietin treated cells at essentially all concentrations of paclitaxel tested. Western blot analyses revealed that the long-term Epo treated cells had significantly reduced expression of apoptosis-related proteins Bcl-2 and Bcl-10. These findings may have implications for the clinical use of recombinant human Epo and other erythropoiesis stimulating agents to correct anemia in paclitaxel-treated cancer patients.

Characterization of erythropoietin receptor and erythropoietin expression and function in human ovarian cancer cells.

The identification of erythropoietin receptors (EpoR) on cancer cells has caused concern, since it implies the possibility that treatment of cancer patients with erythropoietin (Epo) and related agents with demonstrable antiapoptotic activity could enhance cancer growth and progression. However, the function and even the validity of the identification of these receptors have been called into question. We now report the characterization of EpoR and Epo expression by 4 human ovarian cancer cell lines: A2780, CaOV, SKOV and OVCAR-3. Using semiquantitative RT-PCR, restriction digestion of the PCR products and DNA sequence analysis, we determined that each of the lines expresses the EpoR and Epo at the mRNA level. A2780 cells were the highest expressers of both genes. We demonstrated EpoR protein both by western blotting and by immunofluorescence and biologically active Epo protein by quantitative in vitro bioassay. The EpoR on A2780 cells was shown to be functional, since Epo stimulation resulted in phosphorylation of Erk1/2, an important EpoR mitogenic signaling intermediate. None of the cell lines exhibited a growth response in culture to exogenous Epo. However, addition of a neutralizing anti-Epo antibody to A2780 cells resulted in partial growth inhibition that was reversed by the addition of excess Epo, providing evidence for an autocrine/paracrine mechanism of growth enhancement in these cells.

Monolingual and Bilingual Recognition of Regular and Irregular English Verbs: Sensitivity to Form Similarity Varies with First Language Experience.

We used a cross-modal priming procedure to explore the processing of irregular and regular English verb forms in both monolinguals and bilinguals (Serbian-English, Chinese-English). Materials included irregular nested stem (drawn-DRAW), irregular change stem (ran-RUN), and regular past tense-present tense verb pairs that were either low (guided-GUIDE) or high (pushed-PUSH) in resonance, a measure of semantic richness. Overall, semantic richness of irregular verbs (nested and irregular change) and of regular verbs (high and low resonance) was matched. Native speakers of English revealed comparable facilitation across regularity and greater facilitation for nested than change stem irregulars. Like native speakers, Serbian, but not Chinese bilinguals matched for proficiency, showed facilitation due to form overlap between irregular past and present tense forms with a nested stem. Unlike native speakers, neither group showed reliable facilitation to stem change irregulars. Results demonstrate the influence of first language on inflectional processing in a second language.