Subject(s)
Disease Progression , Eccrine Glands/pathology , Hamartoma/pathology , Nevus, Intradermal/pathology , Porokeratosis/pathology , Adult , Biopsy, Needle , Diagnosis, Differential , Drug Therapy, Combination , Follow-Up Studies , Hamartoma/diagnosis , Hamartoma/drug therapy , Humans , Immunohistochemistry , Male , Nevus, Intradermal/diagnosis , Nevus, Intradermal/drug therapy , Porokeratosis/diagnosis , Porokeratosis/drug therapy , Rare Diseases , Risk Assessment , Treatment FailureABSTRACT
Xanthelasmoid or pseudoxanthomatous mastocytosis is an extremely rare variant of diffuse cutaneous mastocytosis. Herein, we describe an adult male with cutaneous mastocytosis showing multiple widespread yellowish ovoid papules like eruptive xanthoma. A 60-year-old male visited our outpatient clinic with a 1-year history of generalized yellowish, ovoid, and skin color papular eruption located on the trunk, groin, extremities, with the modest pruritus. Vital signs were stable, and Darier's sign was negative. No other subjective and objective signs were detected during the examination. No abnormality was detected in his diagnostic laboratory tests. Skin biopsy was taken, and histopathologic examination revealed proliferation of mast cells with ovoid and spindle nuclei with distinct cytoplasm borders around the capillaries, which was compatible with mastocytosis. Antihistamine was prescribed for pruritus control which was successful, but eruptions were persistent, and even 1-year phototherapy was not useful.
ABSTRACT
BACKGROUND: Although the occurrence of psoriasis and vitiligo is reported in a few studies, no proper relationship has been found between these two diseases. OBJECTIVE: The aim of this study was to identify the frequency of the coincidence of these two diseases. METHOD: A descriptive and cross-sectional study was conducted on 6,200 patients referred to dermatology clinics from September 2004 to June 2005. RESULTS: Among these patients, 219 and 154 patients suffered from psoriasis (3.53%) and vitiligo (2.48%), respectively, and 12 patients (0.19%) had psoriasis and vitiligo simultaneously. The coincidence in the psoriasis group was 5.48% and in the vitiligo group was 7.79%, so the coincidence of both diseases was greater than the incidence of each alone. This association was significant (p = .004). CONCLUSION: Coincidence of these two diseases was seen, but more studies should be done to find common genetic and immunologic factors.
