ABSTRACT
Pemphigus vulgaris (PV) is a potentially fatal autoimmune blistering disease of the skin and mucous membranes, characterized by flaccid bullae that rupture and leave erosions. Its treatment is challenging. Although the use of systemic corticosteroids remains the cornerstone of effective therapeutic regimens for PV, their prolonged administration may lead to serious side effects. It is therefore necessary, for many patients, to add immunosuppressive agents or use immunomodulatory procedures to achieve remission. This paper will summarize the treatments available for PV, while focusing on the most recently available therapeutic options.
Subject(s)
Pemphigus/therapy , Adrenal Cortex Hormones/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Drug Therapy, Combination , Humans , Immunosuppressive Agents/therapeutic use , Immunotherapy/methodsSubject(s)
Drug Eruptions/etiology , Ibuprofen/adverse effects , Interleukin-2/adverse effects , Pemphigoid, Bullous/chemically induced , Penicillins/adverse effects , Acquired Immunodeficiency Syndrome/complications , Adult , Aged , Child , Child, Preschool , Diagnosis, Differential , Drug Eruptions/complications , Drug Eruptions/diagnosis , Drug Eruptions/therapy , Female , Humans , Male , Middle Aged , Pemphigoid, Bullous/complications , Pemphigoid, Bullous/diagnosis , Pemphigoid, Bullous/therapy , Radiation Injuries/etiology , Radiotherapy/adverse effectsSubject(s)
Amoxicillin/adverse effects , Drug Eruptions/etiology , Penicillins/adverse effects , Adult , Drug Interactions , Female , HumansSubject(s)
Drug Hypersensitivity/etiology , Penicillins/adverse effects , Adolescent , Adult , Anaphylaxis/chemically induced , Anemia, Hemolytic/chemically induced , Child , Desensitization, Immunologic , Drug Eruptions/etiology , Drug Hypersensitivity/therapy , Female , Humans , Middle Aged , Pemphigus/chemically induced , Pregnancy , Skin Diseases, Vesiculobullous/chemically induced , Urticaria/chemically inducedABSTRACT
A retrospective study of patients with pemphigus vulgaris, drug eruptions, psoriasis, and normal controls was undertaken in an attempt to determine whether a significant difference in drug exposure and/or drug allergy existed between the various groups. A statistically significant difference in drug exposure was found between pemphigus vulgaris and drug eruption patients, as compared with psoriatics and normal patients. Representative case reports and some possible mechanisms for the induction or exacerbation of pemphigus patients is described and discussed.
Subject(s)
Drug Hypersensitivity/complications , Pemphigus/etiology , Aged , Female , Humans , Male , Middle Aged , Penicillins/adverse effects , Psoriasis/drug therapy , Retrospective Studies , Scalp/pathology , Skin/immunologySubject(s)
Ampicillin/adverse effects , Pemphigus/chemically induced , Penicillins/adverse effects , Female , Humans , Male , Middle AgedABSTRACT
Keratoacanthomas have been associated with multiple carcinomas, discoid lupus erythematosus, and multiple sebaceous gland tumors with colonic and gastric carcinoma. Steatocystoma multiplex has been associated with ichthyosis and koilonychia, pachyonychia congenita, multiple hairs and acrokeratosis verruciformis of Hopf, hypertrophic lichen planus, hypohidrosis, hypothyroidism, hidradenitis suppurativa, and hypotrichosis. We report a case of multiple keratoacanthoma associated with steatocystoma multiplex and rheumatoid arthritis.
Subject(s)
Arthritis, Rheumatoid/complications , Epidermal Cyst/complications , Keratoacanthoma/complications , Skin Diseases/complications , Epidermal Cyst/genetics , Epidermal Cyst/pathology , Humans , Keratoacanthoma/pathology , Male , Middle Aged , Skin/pathology , Skin Diseases/pathologyABSTRACT
A 39-year-old man developed allergic hypersensitivity to lidocaine hydrochloride and showed urticarial dermographism. Although hypersensitivity reactions to local anesthetics are rare and are usually due to esters of procaine, reaction to the amides of lidocaine can occur. A review of the literature for the past decade revealed only four reported cases of allergic hypersensitivity to lidocaine hydrochloride.
Subject(s)
Drug Hypersensitivity/etiology , Lidocaine/immunology , Adolescent , Adult , Anesthesia, Dental/adverse effects , Child , Female , Humans , Lidocaine/adverse effects , Male , Middle Aged , Skin Tests , Urticaria/chemically inducedABSTRACT
The skin of 41 patients including 16 blacks, 15 Caucasians, and 10 Hispanics, was observed using a fluorescent microscope. Three patterns of autofluorescence were observed: intercellular, cytoplasmic, and a combination of intercellular and cytoplasmic. The hair of 75 subjects, including 18 Negroes and 55 Caucasians, was observed. Two patterns were found: medullar and at the cortex. Skin form black patients was associated with the cytoplasmic pattern of autofluorescence. Compared to lighter skin, black skin was also significantly associated with increased intensity of autofluorescence, indicating that autofluorescence of the epidermis parallels the clinical degree of pigmentation. In the hair of 75 subjects, similar results were obtained: Negro hair exhibited more fluorescence than Caucasian hair, and darker hair (brown to black) exhibited more fluorescence than lighter hair (blond). This may be related to melanin and it breakdown products.
