ABSTRACT
We hypothesized that the IL-1ß-511 C>T polymorphism could be associated with the development of neurotoxicity and that it could be a possible biomarker to rate the risk of occurrence of neurotoxicity in cancer patients. Genomic DNA was extracted from 85 cancer patients: 49 received systemic chemotherapeutic treatment (CHT) and 36 patients did not receive it (No-CHT). All subjects were genotyped for the functionally active polymorphisms of IL-1ß-511 C>T. We estimated neurotoxicity with the evaluation of neurological deficits. CHT patients showed erythrocytopenia, neurological deficit and a slight lowering of cognitive performance. The subgroup of patients carrying the CC genotype of the IL-1ß-511 C>T gene showed lesser neurological deficits. In the context of cancer treatment, we suggested the potential value of IL-1ß-511 C>T as genetic biomarkers to identify patients with higher risk to develop neurological deficits.
Subject(s)
Antineoplastic Agents/adverse effects , Genetic Predisposition to Disease , Homozygote , Interleukin-1beta/genetics , Neurotoxicity Syndromes/genetics , Polymorphism, Single Nucleotide , Antineoplastic Agents/therapeutic use , Female , Genotyping Techniques , Humans , Male , Mental Status Schedule , Middle Aged , Neoplasms/complications , Neoplasms/drug therapy , Neoplasms/genetics , Neuropsychological TestsABSTRACT
OBJECTIVE: Several lines of evidence indicate a role for inflammatory processes in the development of cerebral aneurysms. Recently, polymorphisms in the promoter region of the interleukin 6 (IL6) gene were shown to be associated with intracranial aneurysmal disease. The purpose of this study was to verify the association of two functionally active polymorphisms (-174 G>C and -572 G>C) in the promoter region of the IL6 gene with the risk and clinical features of aneurysmal subarachnoid haemorrhage (SAH) in an Italian population. METHODS: A total of 179 consecutive aneurysmal SAH patients and 156 healthy controls were involved in the study. Cases and controls were genotyped for the -174 GSubject(s)
Genetics, Population
, Interleukin-6/genetics
, Intracranial Aneurysm/genetics
, Polymorphism, Genetic/genetics
, Promoter Regions, Genetic/genetics
, Subarachnoid Hemorrhage/genetics
, Adult
, Aged
, Female
, Gene Frequency
, Genetic Predisposition to Disease/genetics
, Genotype
, Haplotypes
, Humans
, Italy
, Male
, Middle Aged
, Risk Factors
ABSTRACT
Several studies have suggested that iron metabolism may be involved in the pathogenesis of migraine. Using a case-control design, we performed an association study in a cohort of Italian migraine patients to evaluate whether a particular allele or genotype of the haemochromatosis gene (HFE) would modify the occurrence and clinical features of the disease. We genotyped 256 migraine patients and 237 healthy age-, sex- and ethnicity-matched controls for the C282Y and H63D polymorphisms of the HFE gene. Phenotype and allele frequencies of both polymorphisms were similarly distributed in migraine patients and controls. The patients carrying the DD genotype of the H63D polymorphism showed a later age at onset of the disease and an increased number of migraine attacks. Our data suggest that the HFE gene is not a major disease gene for migraine. However, the H63D polymorphism of the HFE gene may be considered a modifying genetic factor in migraine.
