[Relationship between mass of the left ventricular myocardium and uric acid metabolic imbalance in patients with arterial hypertension]. / Sviaz' mezhdu massoi miokarda levogo zheludochka i narusheniem obmena mochevoi kisloty u bol'nykh arterial'noi gipertoniei.

AIM: To analyse relationships between left ventricular myocardium mass (LVMM) and imbalance of uric acid metabolism in patients with arterial hypertension (AH). MATERIAL AND METHODS: Body mass index, waist/hip circumference index, levels of uric acid in the blood and urine, urinary excretion of albumin, LVMM were estimated in 106 patients with mild and moderate AH (70 males and 36 females, mean age 51 +/- 8.5 years). RESULTS: Hypertensive patients with and without metabolic imbalance of uric acid differ significantly by LVMM index. The latter was higher in metabolic imbalance of uric acid, being the highest if this imbalance combined with microalbuminuria. CONCLUSION: Imbalance of uric acid metabolism in AH patients may indicate affection of both the kidneys and the heart.

[Urate affection of kidneys and metabolic disturbances in hypertensive patients]. / Uratnoe porazhenie pochek i metabolicheskie sdvigi u patsientov s arterial'noi gipertoniei.

AIM: To detect urate renal affection and correlations between purine metabolism, hyperinsulinemia, obesity, dyslipidemia in patients with arterial hypertension (AH). MATERIALS AND METHODS: 78 patients with mild, moderate and severe hypertension have undergone 24-h monitoring of arterial pressure and microalbuminuria test. RESULTS: Hyperuricemia was diagnosed in 21 of 78, hyperuricosuria in 27 patients. 13 patients had combination of hyperinsulinemia with obesity, dyslipidemia, arterial hypertension. Renal symptoms occurred in almost half of the patients with hyperuricemia. Disturbed 24-h rhythm and variability of arterial pressure were encountered more frequently in patients with hyperuricemia and hyperinsulinemia than in patients with normal purin metabolism and no other metabolic shifts. CONCLUSION: Renal abnormalities were found more frequently in hypertensive patients with hyperuricemia and those free of urate disturbances and metabolic changes. A positive correlation exists between body mass index and insulinemia (r = 0.58, p < 0.01), body mass index and uricemia (r = 0.37, p < 0.01), insulinemia and uricemia (r = 0.32, p < 0.01).

[Hyperbaric oxygenation and antiaggregants: effects on platelet function in patients with ischemic heart disease]. / Giperbaricheskaia oksigenatsiia i antiagregantnye preparaty: vliianie na funktsional'noe sostoianie trombotsitov u bol'nykh ishemicheskoi bolezniu serdtsa.

Platelet function (duration and percentage of aggregation and disaggregation) was studied in 65 chronic coronary patients over the course of hyperbaric oxygenation and antiaggregant therapy. A course of hyperbaric oxygenation (8 to 12 sessions at absolute atmosphere of 1.3-1.6 for 40 min) had no proaggregant or antiaggregant effects on the platelets in this category of patients. Aspirin in a daily dose of 125 mg and pentoxifylline in a daily dose of 300 mg reliably decreased the percentage of platelet aggregation and increased the share of disaggregation. Hyperbaric oxygenation in the above mode did not change the antiaggregant activity of these drugs.