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Z Naturforsch C J Biosci ; 58(3-4): 215-9, 2003.
Article in English | MEDLINE | ID: mdl-12710731

ABSTRACT

Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 microM and 20 microM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.


Subject(s)
Antiviral Agents/chemistry , Limonins/chemistry , Limonins/pharmacology , Melia azedarach/chemistry , Monoterpenes/chemistry , Monoterpenes/pharmacology , Antiviral Agents/isolation & purification , Antiviral Agents/pharmacology , Biological Assay , Herpesvirus 1, Human/drug effects , Limonins/isolation & purification , Microbial Sensitivity Tests , Monoterpenes/isolation & purification , Plant Leaves/chemistry , Vesicular stomatitis Indiana virus/drug effects
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