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Oncogene ; 28(2): 279-88, 2009 Jan 15.
Article in English | MEDLINE | ID: mdl-18836480

ABSTRACT

The recepteur d'origine nantais (RON) is a receptor tyrosine kinase (RTK) in the scatter factor family, which includes the c-Met receptor. RON exhibits increased expression in a significant number of human breast cancer tissues as well as in many established breast cancer cell lines. Recent studies have indicated that in addition to ligand-dependent signaling events, RON also promotes signals in the absence of its only known ligand, MSP, when expressed in epithelial cells. In this study, we found that when expressed in MCF-10A breast epithelial cells, RON exhibits both MSP-dependent and MSP-independent signaling, which lead to distinct biological outcomes. In the absence of MSP, RON signaling promotes cell survival, increased cell spreading and enhanced migration in response to other growth factors. However, both RON-mediated proliferation and migration require the addition of MSP in MCF-10A cells. Both MSP-dependent and MSP-independent signaling by RON are mediated in part by Src family kinases. These data suggest that RON has two alternative modes of signaling that can contribute to oncogenic behavior in normal breast epithelial cells.


Subject(s)
Breast/cytology , Cell Transformation, Neoplastic , Epithelial Cells/enzymology , Hepatocyte Growth Factor/physiology , Proto-Oncogene Proteins/physiology , Receptor Protein-Tyrosine Kinases/physiology , Signal Transduction/physiology , Animals , Cell Adhesion/drug effects , Cell Adhesion/physiology , Cell Division/drug effects , Cell Division/physiology , Cell Line/cytology , Cell Line/drug effects , Cell Line/enzymology , Cell Line, Transformed/cytology , Cell Line, Transformed/drug effects , Cell Line, Transformed/enzymology , Cell Movement/drug effects , Cell Movement/physiology , Cell Shape/drug effects , Cell Shape/physiology , Cell Survival/drug effects , Cell Survival/physiology , Epithelial Cells/cytology , Epithelial Cells/drug effects , Female , Humans , Mice , NIH 3T3 Cells/cytology , NIH 3T3 Cells/drug effects , Phosphatidylinositol 3-Kinases/physiology , Phosphoinositide-3 Kinase Inhibitors , Phosphorylation/drug effects , Protein Kinase Inhibitors/pharmacology , Protein Processing, Post-Translational/drug effects , Proto-Oncogene Proteins c-akt/antagonists & inhibitors , Proto-Oncogene Proteins c-akt/physiology , Receptor Protein-Tyrosine Kinases/genetics , Signal Transduction/drug effects , src-Family Kinases/physiology
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