ABSTRACT
A monocyclic "temple" synthetic lectin, with extended electron-rich aromatic surfaces, shows enhanced affinities for carbohydrates in water. The methoxy substituents favour binding to α-linked maltodextrins, against the all-equatorial substrates normally favoured by this family of receptors.
ABSTRACT
Phytochemical investigations of the n-butanol soluble sub-fraction of the methanolic extract of Galinsoga parviflora Cav. has led to the isolation of two new glucosides named as parvisides A (1) and B (2). Their structures have been assigned on the basis of their spectral analysis including 1D and 2D NMR techniques.
Subject(s)
Asteraceae/chemistry , Glucosides/chemistry , Plant Extracts/chemistry , Glucosides/isolation & purification , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Extracts/isolation & purificationABSTRACT
Galinosoates A-C (1-3), new aromatic esters, have been isolated from the n-hexane soluble fraction of Galinsoga parviflora. Their structures were assigned from the spectral data including IR, HR-EI-MS, 1D and 2D NMR.
Subject(s)
Asteraceae/chemistry , Benzene Derivatives/isolation & purification , Benzene Derivatives/chemistry , Esters , Hexanes , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular , PakistanABSTRACT
Phytochemical investigation of the ethyl acetate soluble fraction of the methanol soluble extract of the roots of Daphne oleoides resulted in isolation and identification of two new isomeric biisoflavonoids characterized as 8,8"-bi-6-hydroxyorobol (1) and 8,8"-bi-6, 2'-dihydroxygenistein (2). The structures of these compounds were established by analysis of their 1D and 2D NMR and HRMS data.
Subject(s)
Daphne/chemistry , Flavonoids/chemistry , Isoflavones/chemistry , Plant Roots/chemistry , Chromatography, High Pressure Liquid , Indicators and Reagents , Magnetic Resonance Spectroscopy , Mass Spectrometry , Plant Extracts/chemistry , Spectrometry, Mass, Fast Atom Bombardment , Spectrophotometry, Infrared , Spectrophotometry, UltravioletABSTRACT
Galinsosides A (1) and B (2), new flavanone glucosides together with two known flavanones, 7,3',4'-trihydroxyflavanone (3) and 3,5,7,3',4'-pentahydroxyflavanone (4) have been isolated from an ethyl acetate- soluble fraction of Galinsoga parviflora. Their structures were assigned on the basis of spectral studies. Compound 1 showed significant antioxidant and urease inhibitory activity while compound 2 was moderately active. On the other hand, 2 showed inhibitory potential against alpha-glucosidase.
Subject(s)
Asteraceae/chemistry , Flavanones , Glucosides , Plant Extracts/chemistry , Plant Extracts/pharmacology , Antioxidants/chemistry , Antioxidants/pharmacology , Flavanones/chemistry , Flavanones/pharmacology , Glucosides/chemistry , Glucosides/pharmacology , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Structures/chemistry , Urease/antagonists & inhibitorsABSTRACT
Silymins A (1) and B (2), the new pentacyclic triterpenes, have been isolated from ethyl acetate fraction of Silybum marianum and their structures assigned from 1H and 13C NMR spectra, DEPT and by 2D COSY, NOE and HMBC experiments.
Subject(s)
Silybum marianum/chemistry , Triterpenes/chemistry , Cyclization , Hydrogen , Magnetic Resonance Spectroscopy/methods , Reference Standards , Triterpenes/isolation & purificationABSTRACT
Hyperinols A (1) and B (2) are new taraxastane type triterpenes which have been isolated from the chloroform soluble fraction of Hypericum oblongifolium and their structures elucidated on the basis of spectroscopic data. Both showed significant inhibitory activity against chymotrypsin enzyme.
Subject(s)
Chymotrypsin/antagonists & inhibitors , Hypericum/chemistry , Triterpenes/pharmacology , Trypsin Inhibitors/pharmacology , Chloroform/chemistry , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Molecular Structure , Solutions/chemistry , Triterpenes/chemistry , Trypsin Inhibitors/chemistryABSTRACT
Marianine, the new lanostane triterpene (1) and marianosides A (2) and B (3) have been isolated from the whole plant of Silybum marianum. Their structures were elucidated on the basis of extensive analysis of their one dimensional and two dimensional nuclear magnetic resonance (1D, 2D-NMR) spectral data. All inhibited chymotrypsin in a concentration-dependent manner.
Subject(s)
Asteraceae/chemistry , Chymotrypsin/antagonists & inhibitors , Glucosides/pharmacology , Triterpenes/pharmacology , Trypsin Inhibitors/pharmacology , Carbohydrate Conformation , Chloroform , Glucosides/isolation & purification , Hydrolysis , Magnetic Resonance Spectroscopy , Plant Extracts/chemistry , Solvents , Spectrophotometry, Infrared , Spectrophotometry, Ultraviolet , Triterpenes/isolation & purification , Trypsin Inhibitors/isolation & purificationABSTRACT
Haloxylines A (1) and B (2), new piperidine alkaloids, have been isolated from the chloroform soluble fraction of Haloxylon salicornicum and their structures elucidated by spectroscopic techniques including 2D-NMR. Both the compounds displayed antifungal and cholinesterase enzymes inhibitory potentials.
