ABSTRACT
Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from different perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiological, genetic, molecular, structural, functional, physiological and preclinical evidence available.
Subject(s)
Disease Progression , Migraine Disorders/diagnostic imaging , Migraine Disorders/physiopathology , Chronic Disease , Epigenesis, Genetic/physiology , Humans , Migraine Disorders/genetics , Neuroimaging/trendsABSTRACT
The errors and deficiencies of current sight testing due to lack of adequate tools or training are highlighted. Some useful techniques and methods, especially for non-specialist personnel, are suggested as a way of improving the evaluation of eyesight.
