ABSTRACT
BACKGROUND: XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the DNA base excision repair mechanism. Single nucleotide polymorphisms (SNPs) in the XRCC1 gene are thought to modulate DNA repair capacity and have been linked to cancer risk in several studies. MATERIALS AND METHODS: We conducted a case-control study comprising 217 cervical samples, including 103 cervical carcinomas and 114 normal tissue samples. Cervical samples were genotyped for two XRCC1 SNPs (Arg194Trp and Arg399Gln) by PCR-RFLPs. RESULTS: Subjects carrying heterozygous Arg399Gln or the combined Gln399Gln + Arg399Gln variant genotypes had a significantly reduced risk for cervical cancer development. In addition, the 194Arg-399Gln haplotype was also found to be associated with a decreased risk for cervical carcinoma. CONCLUSION: Our findings suggest that XRCC1 genotypes and haplotypes contribute in reducing the risk for cervical cancer development. Furthermore, genetic susceptibility conferred by Arg399Gln polymorphism operates independently of human papillomavirus infection of cervical tissue.
Subject(s)
DNA-Binding Proteins/genetics , Genetic Predisposition to Disease , Polymorphism, Single Nucleotide , Uterine Cervical Neoplasms/genetics , Adult , Alleles , Argentina , Case-Control Studies , Female , Gene Frequency , Genotype , Haplotypes , Humans , Middle Aged , Papillomaviridae/genetics , Papillomavirus Infections/genetics , Risk , Uterine Cervical Neoplasms/virology , X-ray Repair Cross Complementing Protein 1ABSTRACT
This paper presents the results obtained in an epidemiological survey conducted at Unidad de Pediatría del Hospital General de México, S.S.A., in 1,009 patients, randomly selected. The routine immunization schedule, followed in Mexico during the last few years was investigated. The results are presented for every one of the vaccines, according with the age periods. Considering the group as a whole, the results are significantly low, as far as the recommended standards pretend. It is concluded that it is necessary to strengthen the vaccination program in this country, in order to avoid the possibilities of new breaks of epidemics related with this marked lack of immunization in the community.
Subject(s)
Communicable Disease Control , Vaccination , Vaccines/administration & dosage , Age Factors , Child , Child, Preschool , Evaluation Studies as Topic , Female , Humans , Immunization , Infant , Infant, Newborn , Male , Mass Screening , Mexico , Sex FactorsABSTRACT
This paper includes the chief considerations about the community work in the Integral General Medicine Program Called Plan A36. General considerations are made abour the four years of trainign program in which the medical student in exposed to be in close contac with the most common medical and health problems in his country, and during this period of time, he becomes capable to develop all the techniques to act as a primary contac physicain.