ABSTRACT
El tumor fibroso pleural es un tumor habitualmente asintomático, benigno y de lento crecimiento, que en un pequeño porcentaje de los casos tiene un comportamiento más agresivo. Para definir los criterios de malignidad es necesario un análisis inmunohistoquímico. El tratamiento de elección es la resección quirúrgica completa con márgenes de seguridad ya sea por toracotomía o por videotoracoscopia en función del tamaño. Se encuentra en estudio la utilización de terapia adyuvante radioterápica o quimioterápica que en el momento actual no cuenta con resultados significativos. Presentamos dos casos que fueron tratados de forma quirúrgica, con extirpación completa siendo el primero definido como maligno según los criterios histológicos y el segundo benigno, pero de alto riesgo. Solo uno de ellos recibió terapia adyuvante. (AU)
Solitary fibrous pleural tumor is a usually asymptomatic, benign and slow-growing tumor, which in a small percentage of cases has a more aggressive behavior. To define the malignancy criteria, an immunohistochemical analysis is necessary. The gold standard treatment is a complete surgical resection with safety margins either by thoracotomy or by videothoracoscopy depending on the size. The use of radiotherapy or chemotherapy as an adjuvant therapy is under study, which at the present time does not have significant results. We present two cases that were treated surgically, with complete removal, one being classified as malignant according to histological criteria and the other benign but high risk. Only one of them received adjuvant therapy. (AU)
Subject(s)
Humans , Female , Middle Aged , Aged , Solitary Fibrous Tumor, Pleural/surgery , Solitary Fibrous Tumor, Pleural/classification , Mesothelioma , Solitary Fibrous Tumor, Pleural/therapy , Combined Modality TherapyABSTRACT
The ultrastructural changes produced in the upper mesophyl cells of Spirodela intermedia W. Koch, by the inclusion of polyethylene glycol (PEG) in the nutrient solution, are related to the degree of the osmotically-induced water shortage. The ultrastructural characteristics of the -0.08 MPa treated fronds differed from the untreated ones in the form of the chloroplasts. PEG up to -0.20 MPa induced considerable cell structural disorganization as the swelling, breaking and disappearance of the outer membrane of the chloroplasts and the breakdown of the tonoplast into small vesicles.
Subject(s)
Plant Leaves/metabolism , Plant Leaves/ultrastructure , Water-Electrolyte Balance/physiology , Body Water/drug effects , Body Water/physiology , Dehydration , Organelles/drug effects , Organelles/metabolism , Organelles/ultrastructure , Plant Leaves/drug effects , Polyethylene Glycols/pharmacology , Water-Electrolyte Balance/drug effectsABSTRACT
The ultrastructural changes produced in the upper mesophyl cells of Spirodela intermedia W. Koch, by the inclusion of polyethylene glycol (PEG) in the nutrient solution, are related to the degree of the osmotically-induced water shortage. The ultrastructural characteristics of the -0.08 MPa treated fronds differed from the untreated ones in the form of the chloroplasts. PEG up to -0.20 MPa induced considerable cell structural disorganization as the swelling, breaking and disappearance of the outer membrane of the chloroplasts and the breakdown of the tonoplast into small vesicles.
Subject(s)
Plant Leaves , Water Deprivation/physiology , Water-Electrolyte Balance , Body Water , Organelles , Plant Leaves , Polyethylene Glycols/pharmacology , Water-Electrolyte BalanceABSTRACT
The ultrastructural changes produced in the upper mesophyl cells of Spirodela intermedia W. Koch, by the inclusion of polyethylene glycol (PEG) in the nutrient solution, are related to the degree of the osmotically-induced water shortage. The ultrastructural characteristics of the -0.08 MPa treated fronds differed from the untreated ones in the form of the chloroplasts. PEG up to -0.20 MPa induced considerable cell structural disorganization as the swelling, breaking and disappearance of the outer membrane of the chloroplasts and the breakdown of the tonoplast into small vesicles.(AU)
Subject(s)
Plant Leaves/metabolism , Plant Leaves/ultrastructure , Water Deprivation/physiology , Water-Electrolyte Balance/physiology , Body Water/drug effects , Body Water/physiology , Organelles/drug effects , Organelles/metabolism , Organelles/ultrastructure , Plant Leaves/drug effects , Polyethylene Glycols/pharmacology , Water-Electrolyte Balance/drug effectsABSTRACT
The ultrastructural changes produced in the upper mesophyl cells of Spirodela intermedia W. Koch, by the inclusion of polyethylene glycol (PEG) in the nutrient solution, are related to the degree of the osmotically-induced water shortage. The ultrastructural characteristics of the -0.08 MPa treated fronds differed from the untreated ones in the form of the chloroplasts. PEG up to -0.20 MPa induced considerable cell structural disorganization as the swelling, breaking and disappearance of the outer membrane of the chloroplasts and the breakdown of the tonoplast into small vesicles.
ABSTRACT
This study attempts to find the cause of differences observed between measurements of the thyroid uptake using a thyroid uptake probe and a gamma camera. The thyroid uptakes of 65 patients were measured using the gamma camera with a pinhole collimator and two commercially available thyroid uptake systems. Moreover, simulated thyroid uptake measurements using 0.111 to 7.4 MBq (3 to 200 microCi) of I-123 were also taken using the same probe systems and gamma cameras. Results of the patient and phantom studies were evaluated by regression analyses. The gamma cameras recorded counts in direct proportion to the amount of I-123 in the phantom, but the probe systems exhibited a non-linear relationship. A 20% loss of counts was observed with 1.48 Mq (40 microCi), and up to 50% at the dose relating to a clinically administered dose of 7.4 MBq (200 microCi) in the neck phantom. Because of severe dead-time losses at high count rates associated with counting the capsule standard, the uptake ratios were artifactually higher. The 65 patient study showed a similar trend with the probe technique yielding uptake ratios higher than the gamma camera. Users of thyroid uptake systems should calibrate their instrument's counting efficiency in the dose range of the I-123 activity to be used clinically. To obtain an accurate uptake ratio, the counts must be corrected by calibration factors corresponding to the efficiency of the probe at multiple counting rates including that from counting the intended dose before therapy.
Subject(s)
Gamma Cameras , Hyperthyroidism/diagnostic imaging , Hypothyroidism/diagnostic imaging , Iodine Radioisotopes , Thyroid Gland/diagnostic imaging , Artifacts , Calibration , Humans , Models, Structural , Radionuclide Imaging/instrumentation , Time FactorsABSTRACT
Fifty-six patients with measurable or evaluable advanced gastric cancer were treated with cisplatin, 100 mg/m2 in continuous infusion of 24 hours, and 5-fluorouracil, 1000 mg/m2/day (by continuous 5-day infusion) every 4 weeks. Three patients were found ineligible for the study. A response rate of 41% (22/53) was obtained (95% confidence interval: 28%-54%), with a median duration of remission of 10.2 months and an overall median survival time of 10.6 months. Leukopenia and thrombocytopenia were mild. Nausea and vomiting were common, and 23.5% of the patients had grade 3 stomatitis. Peripheral neuropathy and renal insufficiency increased with the number of cycles, representing the cumulative dose-limiting toxicity. This study indicates that the combination of cisplatin plus 5-fluorouracil is synergistic or at least has additive antitumor activity. We think that this association of 2 drugs should be considered for further phase III clinical trials.
