[Serum IGF-I levels in retinopathy of prematurity. New indications for ROP screening]. / Valores de IGF-I séricos en la ROP. Buscando nuevas indicaciones para su screening.

OBJECTIVE: To determine the IGF-I serum levels in premature infants with the objective of being able to use these levels as an indicator of the need for exploration in a screening program for retinopathy of prematurity (ROP). METHODS: This was a comparative study in which IGF-I levels were measured in every infants' serum during the first exploration in the 4 to 6 postnatal weeks. The degree of ROP and a variety of morbidity factors were evaluated, including the presence of intraventricular haemorrhage, sepsis, need for blood transfusion and the number of days of mechanical ventilation. RESULTS: The average IGF-I values during the first 4 to 6 postnatal weeks were lowest in the ROP cases (10.75 microg/L SD 16.053) while the NO-ROP cases yielded higher values (29.75 microg/L, SD 13.022). The Mann-Whitney U test showed a value of P for the IGF-I values of 0.004, indicating significant differences between the groups with or without ROP. CONCLUSIONS: The low IGF-I serum levels in ROP infants in comparison with the NO-ROP cases, suggest that this marker could be used as an indicator in the screening for ROP.

Valores de IGF-I séricos en la ROP. Buscando nuevas indicaciones para su screening / Serum IGF-I levels in retinopathy of prematurity. New indications for ROP screening

Objetivo: Determinar los niveles séricos IGF-I en niños prematuros con el objetivo de que éstos, pueden ser usados como indicadores de la exploración en el despistaje de la ROP.Método: Nuestro estudio se diseña como transversal comparativo, midiendo los valores de IGF-I en suero de cada niño en la primera exploración entre las primeras 4-6 semanas postnatales. Se evaluaron el grado de ROP y otros factores de morbilidad: hemorragia intraventricular, sepsis, transfusiones y días de ventilación mecánica.Resultados: Los valores medios de la IGF-I entre las 4-6 primeras semanas postnatales fue más baja en los casos de ROP, 10,75 µg/L D.E. 16,053, siendo los casos de No ROP de 29,75 µg/L D.E. 13,022. El test de la U de Mann-Whitney reflejó un valor de la P para los valores de IGF-I de .004, indicando así diferencias significativas entre los dos grupos.Conclusión: Los bajos niveles de IGF-I séricos en niños con ROP en comparación con los casos de no ROP, sugieren que este marcador podría servir como indicador del screening de la ROP

Objective: To determine the IGF-I serum levels in premature infants with the objective of being able to use these levels as an indicator of the need for exploration in a screening program for retinopathy of prematurity (ROP).Methods: This was a comparative study in which IGF-I levels were measured in every infants’ serum during the first exploration in the 4 to 6 postnatal weeks. The degree of ROP and a variety of morbidity factors were evaluated, including the presence of intraventricular haemorrhage, sepsis, need for blood transfusion and the number of days of mechanical ventilation.Results: The average IGF-I values during the first 4 to 6 postnatal weeks were lowest in the ROP cases (10.75 µg/L SD 16.053) while the NO-ROP cases yielded higher values (29.75 µg/L, SD 13.022). The Mann-Whitney U test showed a value of P for the IGF-I values of 0.004, indicating significant differences between the groups with or without ROP.Conclusions: The low IGF-I serum levels in ROP infants in comparison with the NO-ROP cases, suggest that this marker could be used as an indicator in the screening for ROP