ABSTRACT
Neisseria gonorrhoeae is the second most common etiological agent of pelvic inflammatory disease and is currently un-derdiagnosed due to its asymptomatic presentation in 50% of cases. When the disease presents, it may appear in the form of acute abdomen and normal imaging tests, making it a major diagnostic challenge. We present four cases of acute gonococcal peritonitis. The main symptom was acute abdominal pain, and both the gy-necological examination and complementary tests showed normal results. The only notable finding from the laparoscopy was the existence of purulent ascitic fluid. The results of the anatomical and pathological tests were all normal. Endocer-vical and ascitic fluid culture showed infection with N. gonorrhoeae, and in one case, concomitant infection with Chlamydia trachomatis. The definitive treatment applied was intravenous antibiotic therapy. When a sexually active young woman is diagnosed with peritonitis that has no apparent cause, it is important to rule out sexually transmitted diseases.
Subject(s)
Gonorrhea , Pelvic Inflammatory Disease , Chlamydia Infections , Chlamydia trachomatis , Female , Gonorrhea/diagnosis , Humans , Neisseria gonorrhoeaeABSTRACT
Neisseria gonorrhoeae es el segundo agente etiológico de enfermedad inflamatoria pélvica y actualmente sigue infradiagnosticado debido a su presentación asintomática en la mitad de los casos. Cuando presenta síntomas puede debutar con un abdomen agudo y pruebas de imagen normales, suponiendo un importante reto diagnóstico. Se presentan cuatro casos de peritonitis aguda por gonococo. El síntoma principal fue dolor abdominal agudo, mientras que la exploración ginecológica y las pruebas complementarias resultaron normales. Mediante laparoscopia, el único hallazgo relevante fue la existencia de líquido ascítico purulento. El estudio anatomopatológico del apéndice resultó normal en todos los casos. El cultivo endocervical y de líquido ascítico mostró infección por N. gonorrhoeae y, en un caso, infección concomitante con Chlamydia trachomatis. El tratamiento definitivo fue la antibioterapia intravenosa. Ante el diagnóstico de una peritonitis sin causa aparente en una mujer joven sexualmente activa es relevante descartar enfermedades de transmisión sexual
Neisseria gonorrhoeae is the second most common etiological agent of pelvic inflammatory disease and is currently underdiagnosed due to its asymptomatic presentation in 50% of cases. When the disease presents, it may appear in the form of acute abdomen and normal imaging tests, making it a major diagnostic challenge. We present four cases of acute gonococcal peritonitis. The main symptom was acute abdominal pain, and both the gynecological examination and complementary tests showed normal results. The only notable finding from the laparoscopy was the existence of purulent ascitic fluid. The results of the anatomical and pathological tests were all normal. Endocervical and ascitic fluid culture showed infection with N. gonorrhoeae, and in one case, concomitant infection with Chlamydia trachomatis. The definitive treatment applied was intravenous antibiotic therapy. When a sexually active young woman is diagnosed with peritonitis that has no apparent cause, it is important to rule out sexually transmitted diseases
Subject(s)
Humans , Female , Young Adult , Adult , Chlamydia Infections/diagnosis , Gonorrhea/diagnosis , Pelvic Inflammatory Disease/diagnosis , Peritonitis/complications , Anti-Bacterial Agents/therapeutic use , Chlamydia trachomatis/isolation & purification , Chlamydia Infections/microbiology , Diagnosis, Differential , Neisseria gonorrhoeae/isolation & purification , Abdominal Pain/etiology , Laparoscopy , Administration, Intravenous , Hemostasis/drug effects , C-Reactive Protein/analysis , Tomography, X-Ray ComputedABSTRACT
OBJECTIVE: Since the discovery of the SARS-CoV-2 virus, the polymerase chain reaction technique (RT-PCR) has become the fundamental method for diagnosing the disease in its acute phase. The objective is to describe the demand-based series of RT-PCR determinations received at a Microbiology Service at a third-level reference hospital for a health area for three months spanning from the onset of the epidemic by SARS-CoV-2. METHODS: A retrospective analysis of the total of the RT-PCR requested in the Microbiology Service analyzed from 02/25/2020 to 05/26/2020 (90 days) has been carried out. They have been grouped by epidemiological weeks and by the petitioner service. A descriptive analysis was carried out by age, gender and number of requests for each patient. In the tests carried out, a confidence level of 95% (p <0.05) was considered significant. RESULTS: A total of 27,106 requests was received corresponding to 22,037 patients. Median age 53.7 (RIC 40.9-71.7) years, women: 61.3%. Proportion of patients with any positive RT-PCR: 14%. Of the total requests for RT-PCR, positive 3,710. Week 13 had the highest diagnosis performance (39.0%). The primary care has been the service thar has made the most requests (15,953). Patients with 3 or more RT-PCR: 565, of them, 19 patients had a positive result after previously having a negative one. CONCLUSIONS: Requests have been increasing depending on the evolution of the epidemic. The RT-PCR has a high diagnostic performance in the phases of highest contagiousness and / or transmissibility of the virus.
Subject(s)
COVID-19/diagnosis , Pandemics , Reverse Transcriptase Polymerase Chain Reaction/statistics & numerical data , SARS-CoV-2/isolation & purification , Adolescent , Adult , Aged , Aged, 80 and over , COVID-19/epidemiology , Child , Child, Preschool , Confidence Intervals , Female , Health Services Needs and Demand/statistics & numerical data , Humans , Infant , Infant, Newborn , Male , Middle Aged , Primary Health Care/statistics & numerical data , Retrospective Studies , Spain/epidemiology , Statistics, Nonparametric , Young AdultABSTRACT
OBJECTIVE: Our objective was to evaluate the in vitro activity of ceftolozane-tazobactam against multidrug resistant (MDR) and extensively drug-resistant (XDR) non metallo-ß-lactamase producing Pseudomonas aeruginosa clinical isolates at Hospital Universitario Miguel Servet (Zaragoza, Spain) from February 2016 to October 2017. METHODS: We evaluated the in vitro activity of ceftolozane-tazobactam and other antipseudomonal antibiotics against 12 MDR and 117 XDR non metallo-ß-lactamase producing P. aeruginosa isolates. Ceftolozane-tazobactam minimal inhibitory concentrations (MICs) were determined by MIC gradient diffusion test strip. RESULTS: Among the 129 MDR/XDR isolates included, 119 (92.2%) were susceptible to ceftolozane-tazobactam, and ten (7.8%) were resistant. MIC50 was 2 mg/L, and MIC90 4 mg/L. Ceftolozane-tazobactam was the second most active antibiotic after colistin, overtaking amikacin. CONCLUSIONS: Ceftolozane-tazobactam is a valuable treatment option for MDR and XDR P. aeruginosa infections in our setting.
