ABSTRACT
No disponible
Subject(s)
Humans , Female , Infant , Skin/pathology , Job Syndrome/complications , Job Syndrome/diagnosisSubject(s)
Job Syndrome/complications , Skin/pathology , Female , Humans , Infant , Job Syndrome/diagnosisABSTRACT
No disponible
Subject(s)
Humans , Female , Aged, 80 and over , Keratoderma, Palmoplantar/drug therapy , Pruritus/drug therapy , Mite Infestations/drug therapy , Mite Infestations/immunology , Adrenal Cortex Hormones/therapeutic use , Hyperkeratosis, Epidermolytic/drug therapy , Ivermectin/therapeutic use , Petrolatum/therapeutic use , Polymyalgia Rheumatica/complications , Polymyalgia Rheumatica/drug therapy , Diabetes Mellitus/drug therapy , Hypertension/complications , Respiratory Tract Infections/complications , Respiratory Tract Infections/drug therapySubject(s)
Adrenal Cortex Hormones/adverse effects , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Polymyalgia Rheumatica/drug therapy , Pruritus/etiology , Scabies/diagnosis , Scabies/immunology , Aged, 80 and over , Female , Humans , Polymyalgia Rheumatica/immunology , Scabies/complicationsABSTRACT
Alopecia and nail distrophy are rare signs of systemic amyloidosis. We present a case with both manifestations and give a brief review of the cutaneous signs of this disease. A biopsy of affected or unaffected skin may provide the diagnosis.
Subject(s)
Alopecia/etiology , Amyloidosis/pathology , Skin/pathology , Aged , Alopecia/pathology , Amyloidosis/complications , Biopsy , Diagnosis, Differential , Fatal Outcome , Female , Humans , Multiple Myeloma/diagnosisSubject(s)
Carcinoma, Squamous Cell/epidemiology , Epidermolysis Bullosa/epidemiology , Skin Neoplasms/epidemiology , Wound Closure Techniques , Bandages, Hydrocolloid , Carcinoma, Squamous Cell/surgery , Comorbidity , Epidermolysis Bullosa Dystrophica/genetics , Female , Genes, Recessive , Humans , Middle Aged , Skin Neoplasms/surgery , Wound HealingABSTRACT
BACKGROUND: Milia are a usual consultation in dermatologic practice and optimal treatment modalities are not established. OBJECTIVE: To evaluate the efficacy and the safety of CO(2) laser vaporization in the treatment of milia. METHODS: We report four patients, aged from 12 to 50 years old, with different variants of milia: milia en plaque, milia post-photodermatitis, multiple eruptive milia and milia post-trauma. They were treated with the CO(2) laser in superpulsed and focused mode at 2 W/cm(2), with two passes in each session. The follow-up was 12-36 months. RESULTS: All patients showed marked improvement after a few sessions of CO(2) laser. No-one had recurrence or noticeable side effects. CONCLUSION: The CO(2) laser is an option in adult and child patients with multiple milia lesions or milia en plaque, obtaining good cosmetic results with minimal side effects.
Subject(s)
Epidermal Cyst/surgery , Lasers, Gas/therapeutic use , Skin Diseases/surgery , Adolescent , Adult , Anesthesia, Local , Child , Female , Humans , Male , Middle AgedSubject(s)
Anti-Infective Agents/adverse effects , Dermatitis, Allergic Contact/etiology , Diphenhydramine/adverse effects , Drug Eruptions/etiology , Metronidazole/adverse effects , Anti-Infective Agents/administration & dosage , Dermatitis, Allergic Contact/diagnosis , Diphenhydramine/administration & dosage , Drug Eruptions/diagnosis , Drug Therapy, Combination , Female , Humans , Metronidazole/administration & dosage , Middle Aged , Patch Tests/methods , Rosacea/drug therapyABSTRACT
Papular elastorrhexis is a rare entity of elastic tissue characterized by multiple white papules usually located on the trunk. We report a case of papular elastorrhexis in a 22-year-old man with sparse lesions and discuss the main controversial facts in this entity: its consideration as an independent disease or as an incomplete form of Buschke-Ollendorff syndrome and the confusion with and its possible inclusion as a variant of elastic tissue naevi.
Subject(s)
Connective Tissue Diseases/pathology , Elastic Tissue/pathology , Osteopoikilosis/pathology , Skin Neoplasms/pathology , Adult , Biopsy, Needle , Diagnosis, Differential , Humans , Immunohistochemistry , Male , Rare Diseases , Syndrome , Thoracic WallABSTRACT
BACKGROUND: Bowen's disease is a common form of intraepidermal (in situ) squamous cell carcinoma of the skin and mucous membrane. Treatment with destruction of the epidermis by any method is necessary to prevent invasive squamous cell carcinoma. OBJECTIVE: To report our experience with CO2 laser vaporization in the treatment of Bowen's disease and try to identify which factors could have any influence on results. METHODS: A total of 44 patients were treated with the CO2 laser in superpulsed mode, focalized at 2 W/cm2. RESULTS: In 86.3% of patients, a unique treatment session was required. 'Clearance after one treatment' was achieved in 86.3% of the total series of patients and only 7.9% of these patients developed recurrence of the lesion. In 11.3% of the cases, there was 'clearance after more than one treatment' without clinical recurrences in any of these patients during the follow-up. 'No response' was achieved in 2.2% of the total series of patients. CONCLUSION: We conclude that the CO2 laser in superpulsed mode is an effective, efficient, safe, functional and good cosmetics treatment for Bowen's disease and it provides the same recurrence rate as other more aggressive or more expensive modalities of treatment.
Subject(s)
Bowen's Disease/surgery , Laser Therapy , Lasers, Gas/therapeutic use , Skin Neoplasms/surgery , Adult , Aged , Aged, 80 and over , Cohort Studies , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment OutcomeSubject(s)
Fibroma/therapy , Nail Diseases/therapy , Skin Neoplasms/therapy , Tuberous Sclerosis/complications , Adult , Female , Fibroma/etiology , Fibroma/surgery , Humans , Nail Diseases/etiology , Nail Diseases/surgery , Phenol/administration & dosage , Sclerosing Solutions/administration & dosage , Skin Neoplasms/etiology , Skin Neoplasms/surgeryABSTRACT
Histiocytoses are a heterogeneous group of diseases, characterized by the accumulation of reactive or neoplastic histiocytes in various tissues. Generalized eruptive histiocytosis belongs to cutaneous non-Langerhans' cell histiocytoses and is a rare, generalized, self-healing disorder that usually follows a benign clinical course. Herein, we report a case of generalized eruptive histiocytosis in a 41-year-old woman with peculiar clinical and histological features. Clinically, the papules showed a marked distribution into the seborrhoeic areas of the trunk, with a great tendency to coalesce. Furthermore, immunohistochemical labelling demonstrated that the histiocytes were positive for CD68, but negative for CD34, S100, CD1a and XIIIa factor. This is the second report of generalized eruptive histiocytosis with a negative XIIIa factor. We discuss the differential diagnoses of the clinical picture and emphasize that this benign cutaneous disorder should be subjected to close follow-up, owing to the possibility of evolution to a more severe type of histiocytosis or the association with underlying diseases. Spontaneous regression was observed in this actual case.
Subject(s)
Histiocytosis, Non-Langerhans-Cell/diagnosis , Skin Diseases/diagnosis , Adult , Antigens, CD/analysis , Antigens, Differentiation, Myelomonocytic/analysis , Diagnosis, Differential , Factor XIIIa/analysis , Female , Histiocytes/metabolism , Histiocytosis, Non-Langerhans-Cell/immunology , Humans , Immunohistochemistry , Skin Diseases/immunologyABSTRACT
BACKGROUND: Epidermal nevi are benign proliferations of epidermis. Numerous treatment modalities have been tried, but no ideal treatment is yet available. OBJECTIVE: To report our experience with CO(2) laser vaporization in the treatment of verrucous epidermal nevi, and to identify which factors could have influence in long-term results. METHODS: A total of 25 patients were treated with the CO(2) laser in the superpulsed mode, focalized at 2 W/cm(2). The patients were between 3 and 41 years old (mean: 17 years). A total of 44% of lesions were <20 cm(2), 40% measured between 20 and 100 cm(2) and 16% were >100 cm(2). The follow-up was 4-79 months (mean: 28 months). In 76% of patients, multiple treatment sessions were required. RESULTS: Good results were achieved in 92% of patients with soft, flattened nevi and in only 33% patients with keratotic nevi. In addition, 87% of the latter had moderate results and 12.5% had poor results. CONCLUSION: We conclude that the CO(2) laser in superpulsed mode is an effective and safe treatment for verrucous epidermal nevi and provides fewer recurrences than other laser therapies. We also believe that the most determining factor for the cosmetic result is thickness of the nevus.
Subject(s)
Nevus/surgery , Skin Neoplasms/surgery , Adolescent , Adult , Carbon Dioxide , Child , Child, Preschool , Female , Humans , Laser Therapy , Male , Nevus/pathology , Skin Neoplasms/pathology , Treatment OutcomeABSTRACT
INTRODUCTION: Hereditary hemorrhagic telangiectasia (HHT) or Rendu-Osler-Weber disease is an autosomal dominant disorder characterized by epistaxis, mucocutaneous telangiectases and visceral arteriovenous malformations. Cutaneous telangiectases are the most obvious sign of this disorder and are not a merely cosmetic problem owing to their risk for bleeding, which may constitute an authentic matter of concern to these patients. METHODS: Three patients with type-II HHT disease who presented cutaneous and labial lesions were treated with an intense pulsed light (IPL) system associated with a long-pulsed Nd:YAG laser (Photoderm-Vasculight, Lumenis). Labial lesions were treated with the IPL system and cutaneous lesions were treated with the IPL system and the long-pulsed Nd:YAG laser. All treatments were accomplished on an outpatient basis, without anesthesia. RESULTS: All three patients experienced a reduction in the frequency and severity of bleeding episodes and a great cosmetic improvement, with total lesion clearance. Side effects, such as purpura, hypopigmentation, hyperpigmentation or textural changes, were not observed. Recurrences were not detected after a maximum period of 24 months of follow-up. CONCLUSION: The combination of an IPL system and a long-pulsed Nd:YAG laser is efficient and safe for the treatment of cutaneous and labial telangiectases in patients with HHT disease and constitutes an important tool in improving their quality of life.
Subject(s)
Low-Level Light Therapy , Phototherapy , Telangiectasia, Hereditary Hemorrhagic/therapy , Adult , Female , Humans , Low-Level Light Therapy/instrumentation , Middle Aged , Phototherapy/instrumentation , Telangiectasia, Hereditary Hemorrhagic/radiotherapyABSTRACT
Pustular dermatosis of the dorsal hands is a peculiar variant of Sweet's syndrome described by Strutton et al. Nevertheless, not all authors accept this entity. We present a retrospective study of eight cases of neutrophilic vasculitis of the hands. Three patients presented with lesions only on the dorsal hands, three with lesions on the palmar surface and two with lesions on the dorsal and palmar surfaces of the hands. The patients with lesions on the dorsal surface presented a pustular aspect, and the histopathological examination revealed a high degree of vascular damage with presence of vasculitis and, in one case, with fibrinoid necrosis. Therefore, the term pustular vasculitis of the dorsal hands introduced by Strutton et al. should probably be conserved. Our cases may have demonstrated a peculiar clinicopathological disease with its own entity.
