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1.
Infection ; 43(1): 103-6, 2015 Feb.
Article in English | MEDLINE | ID: mdl-25135045

ABSTRACT

The genus Janibacter comprises nine different species mainly found in the environment. Only two human infections by these microorganisms have been previously reported, one by J. melonis and another one by an undescribed Janibacter sp. Herewith we report the first human cases of infection by J. terrae in four bacteremic patients. The microorganisms were isolated from two consecutive blood cultures taken from four febrile patients with several underlying conditions. All patients were treated with antibiotics, two of them with favorable outcome. Two severely immunocompromised patients died, and one was treated with an antibiotic in vitro active against the isolate. Janibacter terrae was identified by phenotypic and 16S rDNA amplification methods. This report includes also the first data on antimicrobial susceptibility of this opportunistic pathogen. Clinical microbiologists should be aware of this microorganism which can be identified by phenotypic and molecular methods.


Subject(s)
Actinobacteria , Bacteremia , Gram-Positive Bacterial Infections , Actinobacteria/drug effects , Actinobacteria/isolation & purification , Aged , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged
2.
Eur J Clin Microbiol Infect Dis ; 28(6): 677-81, 2009 Jun.
Article in English | MEDLINE | ID: mdl-19089476

ABSTRACT

Fifteen Corynebacterium ureicelerivorans isolates were recovered in pure culture from six patients during a five-year period. Five patients had bacteremia and the other was an infection of ascitic fluid. The API Coryne numerical profile obtained corresponds to the profile for C. bovis, while Biolog GP2 identified four out of the six isolates as C. jeikeium. The organisms were molecular identified by 16S rDNA and rpoB. The present report also includes information on new phenotypic tests and, for the first time, antimicrobial susceptibility data of C. ureicelerivorans and their rpoB sequences. All macrolide-resistant isolates presented a constitutive MLS phenotype. This organism must be differentiated from other slow-growing, lipophilic, and urea-splitting corynebacteria.


Subject(s)
Corynebacterium Infections/microbiology , Corynebacterium/classification , Corynebacterium/isolation & purification , Adolescent , Adult , Aged , Animals , Bacteremia/microbiology , Bacterial Proteins/genetics , Bacterial Typing Techniques , Cluster Analysis , Corynebacterium/genetics , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , DNA, Ribosomal/chemistry , DNA, Ribosomal/genetics , DNA-Directed RNA Polymerases/genetics , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Molecular Sequence Data , Peritonitis/microbiology , Phylogeny , RNA, Ribosomal, 16S/genetics , Sequence Analysis, DNA
3.
Eur J Clin Microbiol Infect Dis ; 27(3): 177-84, 2008 Mar.
Article in English | MEDLINE | ID: mdl-17992547

ABSTRACT

Fourteen Corynebacterium coyleae isolates were recovered from 12 in-patients during a 5-years period. In six patients, the isolates were considered as clinically significant, three definite (sepsis), two probable (sepsis and soft tissue infection), and one possible (post-transfusional bacteremia). In the remaining 6 patients (all neonatal bacteremias), there was not enough data for considering the isolates as clinical significant. API Coryne identified all isolates as C. jeikeium, while Biolog GP2 correctly identified 7 out of the 14 isolates. Definitive identification was achieved in all isolates by the sequencing of a fragment of 724 to 1423 pb of 16S rDNA. Successive isolations from two patients presented identical random amplified polymorphic DNA (RAPD) profiles. All of the isolates were in-vitro-sensitive to beta-lactams, gentamicin, rifampin, tetracycline, vancomycin, linezolid, and resistant to clindamycin. Resistance to erythromycin occurred in 83.3% of isolates, all of them presenting phenotype cMLS and harboring the gene ermX.


Subject(s)
Corynebacterium Infections/microbiology , Corynebacterium Infections/physiopathology , Corynebacterium/isolation & purification , Adult , Aged , Anti-Bacterial Agents/pharmacology , Bacterial Typing Techniques , Corynebacterium/classification , Corynebacterium/genetics , Corynebacterium/metabolism , DNA Fingerprinting , DNA, Bacterial/chemistry , DNA, Bacterial/genetics , DNA, Ribosomal/chemistry , DNA, Ribosomal/genetics , Drug Resistance, Bacterial , Female , Humans , Infant, Newborn , Male , Microbial Sensitivity Tests , RNA, Ribosomal, 16S/genetics , Random Amplified Polymorphic DNA Technique , Sepsis/microbiology , Sequence Analysis, DNA , Soft Tissue Infections/microbiology
5.
Med Clin (Barc) ; 98(11): 419-22, 1992 Mar 21.
Article in Spanish | MEDLINE | ID: mdl-1533260

ABSTRACT

Three cases of encrusted cystitis caused by Corynebacterium group D2 are described. The vesical damage previous to the establishment of this bacteria is noteworthy and the very rapid increase in urease activity explains the pathogenesis of the situation. Thus allowing for its identification and is relevant to treatment. Cloudy urine with a strong smell of ammonium, alkaline pH and crystals of ammonium magnesium phosphate in the sediment will bring this microorganism and its characteristic growth pattern to mind thus avoiding a falsely negative report. Treatment combining an antimicrobial agent and cystoscopic resection of the encrusted stones, where Corynebacterium group D2 has lodged, has proved efficacious. Vancomycin and teicoplanin have always been active and are eliminated through the kidneys.


Subject(s)
Corynebacterium Infections/microbiology , Cystitis/microbiology , Urinary Bladder Calculi/etiology , Aged , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Corynebacterium/isolation & purification , Cystitis/complications , Cystitis/drug therapy , Female , Glycopeptides/therapeutic use , Humans , Male , Middle Aged , Teicoplanin , Urinary Bladder Calculi/diagnosis , Urinary Bladder Calculi/surgery , Vancomycin/therapeutic use
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