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1.
Bile acid receptor protects against diabetic cardiomyopathy.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(7): 440, 2024 07.
Article in English | MEDLINE | ID: mdl-38769466

Subject(s)
Diabetic Cardiomyopathies , Diabetic Cardiomyopathies/prevention & control , Animals , Humans
2.
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(7): 438, 2024 07.
Article in English | MEDLINE | ID: mdl-38806634

Subject(s)
Bariatric Surgery , Glucagon-Like Peptide-1 Receptor , Heart Failure , Humans , Bariatric Surgery/adverse effects , Bariatric Surgery/methods , Glucagon-Like Peptide-1 Receptor/agonists , Obesity/surgery , Treatment Outcome , Hypoglycemic Agents/therapeutic use , Diabetes Mellitus, Type 2/drug therapy
3.
Gut bacteria can break down cholesterol.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(6): 357, 2024 06.
Article in English | MEDLINE | ID: mdl-38627565

Subject(s)
Cholesterol , Gastrointestinal Microbiome , Humans , Cholesterol/blood , Animals
4.
A newly identified gut hormone suppresses cholesterol production in the liver.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(6): 358, 2024 06.
Article in English | MEDLINE | ID: mdl-38548956

Subject(s)
Cholesterol , Liver , Humans , Cholesterol/metabolism , Cholesterol/blood , Liver/metabolism , Liver/drug effects , Animals , Gastrointestinal Hormones/metabolism
5.
An epigenome editing approach induces durable silencing of Pcsk9.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(5): 279, 2024 05.
Article in English | MEDLINE | ID: mdl-38480792

Subject(s)
Epigenome , Proprotein Convertase 9 , Humans , Proprotein Convertase 9/genetics , Gene Editing , Epigenesis, Genetic
6.
DYRK1A gene linked to heart defects in Down syndrome.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(4): 217, 2024 04.
Article in English | MEDLINE | ID: mdl-38326439

Subject(s)
Down Syndrome , Heart Defects, Congenital , Humans , Down Syndrome/complications , Down Syndrome/genetics , Dyrk Kinases , Protein Serine-Threonine Kinases/genetics
7.
Base editing therapy corrects long QT syndrome in mice.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(2): 73, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38052971

Subject(s)
Gene Editing , Long QT Syndrome , Mice , Animals , Long QT Syndrome/genetics , Long QT Syndrome/therapy , Electrocardiography
8.
SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(2): 69, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38036669

Subject(s)
Anti-Obesity Agents , Cardiovascular Diseases , Diabetes Mellitus, Type 2 , Glucagon-Like Peptides , Humans , Cardiovascular Diseases/epidemiology , Cardiovascular Diseases/prevention & control , Risk Factors , Heart Disease Risk Factors , Diabetes Mellitus, Type 2/complications , Diabetes Mellitus, Type 2/drug therapy
9.
MINT trial signals potential benefit of liberal transfusion strategy in MI with anaemia.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(2): 70, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38036672
10.
Disrupting a cell-specific miRNA-CXCR4 interaction is atheroprotective in mice.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(1): 9, 2024 01.
Article in English | MEDLINE | ID: mdl-37957335

Subject(s)
Atherosclerosis , MicroRNAs , Animals , Mice , Cell Communication , MicroRNAs/genetics , Receptors, CXCR4/genetics , Signal Transduction , Atherosclerosis/genetics
11.
Photoacoustic method enables deep imaging of blood flow.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(2): 72, 2024 02.
Article in English | MEDLINE | ID: mdl-38102479

Subject(s)
Hemodynamics , Photoacoustic Techniques , Humans , Photoacoustic Techniques/methods
12.
Patisiran is beneficial for the treatment of TTR cardiac amyloidosis.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 21(1): 8, 2024 01.
Article in English | MEDLINE | ID: mdl-37932423

Subject(s)
Amyloidosis , RNA, Small Interfering , Humans , Amyloidosis/therapy , Prealbumin , RNA, Small Interfering/therapeutic use
13.
Sirtuin 2 protects against cardiac ageing.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(12): 796, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37853159

Subject(s)
Aging , Sirtuin 2 , Humans , Heart
14.
Metabolic reprogramming unlocks the regenerative potential of the heart.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(12): 795, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37833501
15.
New insights into OCT-guided PCI.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(11): 720, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37670011

Subject(s)
Coronary Artery Disease , Myocardial Infarction , Percutaneous Coronary Intervention , Humans , Coronary Artery Disease/surgery , Tomography, Optical Coherence , Coronary Angiography , Treatment Outcome , Coronary Vessels
16.
Semaglutide is beneficial in patients with HFpEF and obesity.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(11): 719, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37709935
17.
Heart disease causes sleep disturbances via neuroimmune mechanisms.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(10): 649, 2023 10.
Article in English | MEDLINE | ID: mdl-37580430

Subject(s)
Heart Diseases , Neuroimmunomodulation , Humans , Sleep
18.
Promising novel siRNA for the treatment of hypertension.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(10): 647, 2023 10.
Article in English | MEDLINE | ID: mdl-37524808

Subject(s)
Antihypertensive Agents , Hypertension , Humans , RNA, Small Interfering/genetics , RNA, Small Interfering/therapeutic use , Antihypertensive Agents/therapeutic use , Hypertension/genetics , Hypertension/therapy
19.
Sacubitril-valsartan shows benefit in heart failure with ejection fraction of >40.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(8): 515, 2023 Aug.
Article in English | MEDLINE | ID: mdl-37286705

Subject(s)
Heart Failure , Humans , Stroke Volume , Valsartan , Heart Failure/drug therapy , Aminobutyrates/adverse effects
20.
A fatty acid from mother's milk drives cardiomyocyte maturation in newborn mice.
Fernández-Ruiz, Irene.
Nat Rev Cardiol ; 20(8): 515, 2023 Aug.
Article in English | MEDLINE | ID: mdl-37280300

Subject(s)
Fatty Acids , Mothers , Female , Animals , Mice , Humans , Animals, Newborn , Myocytes, Cardiac , Milk, Human
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