ABSTRACT
BACKGROUND: The Functional Gait Assessment (FGA) is commonly used to measure walking balance. The minimal clinically important difference (MCID) has yet to be determined for the FGA. OBJECTIVE: The purposes of this study were to determine: (1) the MCID in the FGA for older community-dwelling adults relative to patients' and physical therapists' estimates of change and (2) the extent of agreement between patients' and physical therapists' estimates of change. DESIGN: This study was a prospective case series. METHODS: Patients and physical therapists rated the amount of change in balance while walking after an episode of physical therapy for balance retraining on a 15-point global rating of change (GROC) scale. Weighted kappa statistics were calculated to express agreement between patients' and physical therapists' GROC ratings. Functional Gait Assessment change scores were plotted on receiver operating characteristic curves. A cutoff of +3 on the GROC was the criterion used for important change. The optimal FGA change cutoff score for MCID was determined, and sensitivity (SN), specificity (SP), and likelihood ratios (LRs) were calculated. RESULTS: One hundred thirty-five community-dwelling older adults (average age=78.8 years) and 14 physical therapists participated. There was poor agreement between the patients' and therapists' ratings of change (weighted kappa=.163). The estimated MCID value for the FGA using physical therapists' ratings of change as an anchor was 4 points (SN=0.66, SP=0.84, LR+=4.07, LR-=0.40). No accurate value for the FGA MCID could be determined based on the patients' ratings of change. LIMITATIONS: The small sample size was a limitation. CONCLUSION: Poor agreement between therapists' and patients' ratings indicate the need for further communication relative to patient goals. The 4-point MCID value for the FGA can be used for goal setting, tracking patient progress, and program evaluation.
Subject(s)
Gait Disorders, Neurologic/rehabilitation , Gait/physiology , Postural Balance/physiology , Recovery of Function/physiology , Sensation Disorders/rehabilitation , Age Factors , Aged , Aged, 80 and over , Female , Gait Disorders, Neurologic/physiopathology , Gait Disorders, Neurologic/psychology , Humans , Male , Middle Aged , Outcome Assessment, Health Care , Prospective Studies , Self Report , Sensation Disorders/physiopathology , Sensation Disorders/psychology , Sensitivity and SpecificityABSTRACT
A síndrome de hiperestímulo ovariano é uma importante complicação das técnicas de reprodução assistida devido a sua grande morbidade. O mecanismo patogênico básico é o aumento da permeabilidade capilar levando ao extravasamento de líquidos do espaço intravascular para o extravascular, com desenvolvimento de ascite e outros tipos de sufusões, além de hemoconcentração e hipovolemia. A fisiopatologia ainda é motivo de controvérsia. Evidências recentes apontam para o papel de vários mediadores neste processo, sendo que o vascular endothelial growth factor vem sendo envolvido como principal responsável pelo desenvolvimento da síndrome do hiperestímulo ovariano. O presente estudo tem como objetivo revisar sua fisiopatologia e avaliar os recentes avanços descritos na literatura sobre a profilaxia e tratamento da síndrome de hiperestímulo ovariano
