Application of Potentially Probiotic Fruit-Derived Lactic Acid Bacteria Loaded into Sodium Alginate Coatings to Control Anthracnose Development in Guava and Mango During Storage.

This study evaluated the efficacy of potentially probiotic fruit-derived lactic acid bacteria (LAB) strains loaded into sodium alginate (SA) coatings to control the anthracnose development in guava cv. Paluma and mango cv. Palmer caused by distinct pathogenic Colletotrichum species (C. asianum, C. fructicola, C. tropicale, C. siamense, C. karstii, and C. gloeosporioides) during 15 days of room temperature storage (25 ± 0.5 °C). The effects of the formulated coatings on physicochemical parameters indicative of overall postharvest quality of guava and mango were evaluated. The eight examined LAB strains caused strong inhibition on the mycelial growth of all target Colletotrichum species in vitro. LAB strains with the highest inhibitory effects (Levilactobacillus brevis 59, Lactiplantibacillus pentosus 129, and Limosilactobacillus fermentum 263) on the target Colletotrichum species were incorporated into SA coatings. These strains had viable counts of > 6 log CFU/mL in SA coatings during 15 days of room temperature storage. Application of coatings with SA + L. brevis 59, SA + L. pentosus 129, and SA + L. fermentum 263 delayed the development and decreased the severity of anthracnose lesions in guava and mango artificially contaminated with either of the tested Colletotrichum species. These coatings impacted positively on some physicochemical parameters indicative of postharvest quality and more prolonged storability of guava and mango. The formulated SA coatings loaded with tested fruit-derived potentially probiotic LAB strains could be innovative and effective strategies to control postharvest anthracnose and extend the storability of guava and mango.

Surface electromyography to identify top-down modulation in complete chronic spinal cord injury.

BACKGROUND: Complete spinal cord injury (SCI) is characterized by permanent loss of nerve impulse propagation through the injury level leading to complete loss of voluntary muscle contraction. However, clinically undetectable top-down modulation of lower limbs might be present and can be evidenced using surface electromyography (sEMG). CASE REPORT: A subject with complete chronic SCI and no spasticity presents voluntary modulation of sEMG signal during a task-specific activity associated with sensory input. CLINICAL REHABILITATION IMPACT: We present for the first time the spectral characterization of sEMG signal in response to orthostatic training associated with voluntary movement attempts in complete SCI. Behavior of sEMG signal varied according to kinematic properties of movement, reinforcing the voluntary influence of efferent pathways on motor output. Our findings will contribute to elaborate evaluation protocols to investigate the preservation of corticospinal activities, and to evolve more accessible strategies in a clinical setting.

Current Advances on the Development and Application of Probiotic-Loaded Edible Films and Coatings for the Bioprotection of Fresh and Minimally Processed Fruit and Vegetables.

The application of probiotics has emerged as an innovative bioprotection technology to preserve fresh and minimally processed fruit and vegetables. This review discusses the most recent advances on the development and application of probiotic-loaded edible films/coatings as a strategy to preserve fresh or minimally processed fruit and vegetables. Available studies have shown a variety of materials, including hydrocolloids (polysaccharides and proteins) and lipids, used alone or in combination to formulate edible films/coatings loaded with probiotics. Plasticizers and surfactants are usually required to formulate these edible films/coatings. The reported antimicrobial effects of probiotic-loaded edible films/coating and quality parameters of coated fruit and vegetables could vary according to the characteristics of the materials used in their formulation, loaded probiotic strain and its dose. The antimicrobial effects of these films/coatings could be linked to the action of various metabolites produced by embedded probiotic cells with inhibitory effects on microorganisms contaminating fruit and vegetable surfaces. The implication of the use of probiotic-loaded edible films/coatings should be their antimicrobial effects against pathogenic and spoilage microorganisms and efficacy to control the ripening of fruit and vegetables, helping the coated products to maintain their safety, quality, nutritional and functional characteristics for a more prolonged storage period.

Use of Integrative and Complementary Health Practices by professionals in pregnant women with low back pain: integrative review / Uso das Práticas Integrativas e Complementares em Saúde pelos profissionais em gestantes com dores lombares: revisão integrativa

ABSTRACT BACKGROUND AND OBJECTIVES: Integrative and Complementary Health Practices are proposed as possibilities of intervention for women in minimizing the effects of pregnancy and changes associated with this period, especially low back pain. There is a need for health professionals to increase their technical-scientific knowledge in the control of low back pain in pregnant women, as well as to start viewing them as a model of care to be practiced. This study's objective was to analyze the use of integrative and complementary practices by health professionals in pregnant women with low back pain in the national and international literature. CONTENTS: Integrative review in which the search for articles was carried in the following databases: LILACS, BDENF, Scielo, Pubmed, Scopus and Web of Science. The descriptors Pregnant Women, Obstetrics, Low Back, Back Pain and Complementary Therapies were used in Portuguese, English and Spanish. Articles included should have been published from 2006 to 2019 and in the three languages mentioned. After reading the articles, twelve studies were included. With the analysis, two categories were listed: 1) Integrative and Complementary Health Practices used by professionals in pregnant women with back pain and 2) Professionals who use Integrative and Complementary Health Practices in pregnant women with back pain. CONCLUSION: The use of Integrative and Complementary Health Practices by professionals can provide new opportunities, greater knowledge, better assistance to pregnant women, their satisfaction and well-being during pregnancy. Such benefits may represent an advance in health promotion, with the potential to improve care.

RESUMO JUSTIFICATIVA E OBJETIVOS: As Práticas Integrativas e Complementares em Saúde foram propostas como possibilidades de intervenção para as mulheres na minimização dos efeitos da gestação e das modificações associadas a este período, principalmente a dor lombar.Justifica-se pela necessidade de os profissionais da saúde adensar seu conhecimento técnico-científico acerca dessas práticas no controle da dor lombar em gestantes, bem como passarem a ver as mesmas como modelo de cuidado a ser praticado. O objetivo deste estudo foi analisar na literatura nacional e internacional o uso das práticas integrativas e complementares em saúde pelos profissionais em gestantes com dores lombares. CONTEÚDO: Trata-se de uma revisão integrativa em que a busca de artigos foi realizada nas bases/bancos de dados: LILACS, BDENF, Scielo, Pubmed, Scopus e Web of Science. Utilizou-se os descritores Gestantes, Obstetrícia, Dor Lombar, Dor nas Costas e Terapias Complementares nos idiomas português, inglês e espanhol. Os critérios de seleção foram no período de 2006 a 2019 e nos três idiomas citados. Após a leitura dos artigos, foram incluídos 12 estudos e, com a análise, elencados em duas categorias: 1) Práticas Integrativas e Complementares em Saúde utilizadas pelos profissionais em gestantes com dores lombarese 2) Profissionais que utilizam as Práticas Integrativas e Complementares em Saúde em gestantes com dores lombares. CONCLUSÃO: A utilização das Práticas Integrativas e Complementares em Saúde pelos profissionais pode proporcionar novas oportunidades, maior conhecimento, melhor assistência às gestantes, satisfação e bem-estar durante a gestação. Tais benefícios podem representar um avanço na promoção em saúde, com potencial de melhoria da assistência.

Antimicrobial photodynamic therapy against Propionibacterium acnes biofilms using hypericin (Hypericum perforatum) photosensitizer: in vitro study.

Acne vulgaris is the most recurring skin condition in the world, causing great harm to the physical and psychological well-being of many patients. Antimicrobial photodynamic therapy (aPDT) has broad therapeutic applicability. The purpose was to evaluate in vitro the photodynamic inactivation against Propionibacterium acnes (P. acnes) biofilms by using different concentrations of hypericin (Hypericum perforatum) photosensitizer associated with different energies of low-level laser. The biofilms were placed in 96-well microplates with a 6.4-mm diameter surface, by using standard suspensions (2 × 107 CFU/mL) and grown in brain heart infusion broth (BHI) for 48 h in anaerobic chamber. Subsequently, the control group received application of 0.9% sterile saline solution for 3 min; the photosensitising groups received hypericin at concentrations of 5 and 15 µg/mL for 3 min; the laser groups received irradiation of energies of 3 and 5 J (660 nm, continuous output, 100 mW, 30 and 50 s and 100 J/cm2 and 166 J/cm2, respectively); the aPDT groups received 5 and 15 µg/mL concentrations of hypericin associated with energies of 3 and 5 J of low-level laser irradiation. After the biofilms were broken up and seeded for CFU counting. The results showed a reduction in P. acnes biofilms after aPDT emphasising that 15 µg/mL hypericin associated with 3 and 5 J laser irradiation reduced biofilms by 14.1 and 27.9%, respectively. In addition, all groups of aPDT demostrated statistically significant reductions. In vitro photodynamic inactivation against P. acnes biofilms using different concentration of hypericin photosensitizer associated with different energies of low-level laser promoted effective antimicrobial action.

The Effectiveness of Three Irrigation Systems in the Enterococcus faecalis Reduction after Instrumentation with a Reciprocating Instrument.

OBJECTIVE: This study aimed to analyze the effectiveness of three irrigation systems: EndoActivator, passive ultrasonic irrigation (PUI), and Easy Clean in the reduction of Enterococcus faecalis, after instrumentation with the reciprocating system, through microbiological collection and culture method. MATERIALS AND METHODS: A total of 60 extracted human lower premolars were used and standardized at 16 mm in length. The teeth were accessed, contaminated with E. faecalis, and incubated for 21 days at 37°C. Initial collections (S1) were made with an absorbent paper cone to confirm the contamination; subsequently, instrumentation was performed with WaveOne Primary. The teeth were divided into four groups according to the final irrigation protocol (n = 15): group 1. EndoActivator; group 2, PUI; group 3, Easy Clean; and group 4, control group irrigated with saline solution sterile and without agitation. In the final irrigation, the agitation of the 17% ethylene amine tetra-acetic acid (EDTA) solutions was used, then 2.5% sodium hypochlorite (NaOCl); in both for this, three cycles of 20 seconds each. After the chemical-mechanical preparation and agitation of the irrigating solutions, the final collections (S2) for counting the colony-forming units (CFU/mL) occurred. RESULTS: The Kruskal-Wallis test revealed that all the agitation systems reduced by 100% and the control group by 65.7%. CONCLUSION: The control group presented a significantly higher amount of CFU/mL after the chemical-mechanical preparation than the other groups, which were similar to each other (p > 0.05).

In vivo evaluation of painful symptomatology after endodontic treatment with or without the use of photodynamic therapy.

CONTEXT: Postoperative pain control after endodontic treatment is important to maintain patient comfort. AIM: The aim of this prospective clinical study was to evaluate the postoperative symptomatology of endodontic treatments performed in a single session, with or without photodynamic therapy (PDT), using Reciproc #40 file in necrotic unirradicular anterior teeth. MATERIALS AND METHODS: In a prospective clinical study, 40 teeth indicated for endodontic treatment were treated by a single endodontist according to a preestablished protocol. The teeth were randomly divided into two groups (n = 20): control group (CG) and laser group (LG). After 24 h, 72 h, and 1 week of endodontic treatment, patients' pain symptomatology was evaluated through a Visual Analog Scale (VAS) ranging from 0 to 10, in which 0 corresponds to no pain and 10 indicates extreme pain. In both workgroups, similar protocols were used for instrumentation with the Reciproc system (R40), irrigation with 2.5% sodium hypochlorite, and filling by the gutta-percha plastification technique, in which the CG did not use PDT, and the LG used PDT after the instrumentation sequence. After the visit, the patients were given a prescription for ibuprofen 400 mg to be taken every 6 h if they experienced pain. RESULTS: The results of the study, analyzing the VAS, did not show any difference in pain symptoms between the groups at 24 h, 72 h, and 1 week (P > 0.05). CONCLUSIONS: It was concluded that there was no statistical difference between the groups.

Cirurgia parendodôntica como opção para casos especiais: relato de caso / Parendodonic surgery as an option for special cases: case story / Cirugía parendodóntica como opción para casos especiales: relato de caso

A terapia endodôntica consiste em: abertura coronária, modelagem, limpeza, desinfecção, e selamento tridimensional do sistema de canais radiculares. Dentre as etapas constituintes do tratamento, a análise da anatomia interna dos dentes a serem tratados, deve ser cuidadosamente observada e seguir os princípios científicos e biológicos para que sejam minimizadas as possibilidades de falhas e acidentes. Os erros podem ocorrer tanto pela falta de habilidade do profissional, anatomia do elemento a ser tratado ou característica dos instrumentos. Em casos onde há dentes com lesão periapical, por conta de canais calcificados ou obstruídos por instrumentos fraturados, falha do tratamento convencional e impossibilidade de retratamento, é indicada a cirurgia paraendodôntica como opção de tratamento. O objetivo do presente estudo é descrever um relato de caso clínico sobre cirurgia paraendodôntica como tratamento para lesão periapical e manobra cirúrgica para remoção de um instrumento fraturado no terço apical do dente 22. Conclusão: quando o tratamento por via convencional é impossível de ser realizado, a cirurgia paraendodôntica é uma ótima opção de tratamento para dentes com lesões periapicais e para remoção de instrumentos fraturados, sendo uma forma de preservar o órgão dental e evitar extrações preciptadas. No presente estudo foi possível notar radiograficamente a regressão da lesão periapical e clinicamente a ausência de sintomatologia(AU)

The endodontic therapy consists of: coronary opening, modeling, cleaning, disinfection, and three-dimensional sealing of the root canal system. Between the constituent stages of the treatment, the analysis of the internal anatomy of the teeth to be treated, must be carefully observed and follow the scientific and biological principles to minimize the chances of faults and accidents. Errors can occur due to lack of skill of the professional, anatomy of the element to be treated or characteristic of the instruments. In cases where there are teeth with periapical lesions, due to calcified or obstructed channels by fractured instruments, failure of conventional treatment and impossibility of retreatment, paraendodonic surgery is indicated as an option for treatment. The aim of the present study is to describe a clinical case report on para-endodontic surgery as a treatment for periapical injury and surgical maneuver for the removal of a fractured instrument in the apical third of tooth 22. Conclusion: when conventional treatment is impossible to perform, Para-endodontic surgery is an optimal treatment option for teeth with periapical lesions and for the removal of fractured instruments, being a way to preserve the dental organ and avoid precipitated extractions. In the present study it was possible to observe radiographically the regression of the periapical lesion and clinically the absence of symptomatology(AU)

La terapia endodóntica consiste en: apertura coronaria, modelado, limpieza, desinfección, y sellado tridimensional del sistema de canales radiculares. Entre las etapas constituyentes del tratamiento, el análisis de la anatomía interna de los dientes a tratar, debe ser cuidadosamente observado y seguir los principios científicos y biológicos para minimizar las posibilidades de fallas y accidentes. Los errores pueden ocurrir tanto por la falta de habilidad del profesional, anatomía del elemento a ser tratado o característica de los instrumentos. En casos donde hay dientes con lesión periapical, debido a canales calcificados u obstruidos por instrumentos fracturados, falla del tratamiento convencional y imposibilidad de retratamiento, se indica la cirugía paraendodónica como opción de tratamiento. El objetivo del presente estudio es describir un relato de caso clínico sobre cirugía paraendodóntica como tratamiento para lesión periapical y maniobra quirúrgica para remoción de un instrumento fracturado en el tercio apical del diente 22. Conclusión: cuando el tratamiento por vía convencional es imposible de realizar, la cirugía paraendodóntica es una óptima opción de tratamiento para dientes con lesiones periapicales y para remoción de instrumentos fracturados, siendo una forma de preservar el órgano dental y evitar extracciones precipitadas. En el presente estudio fue posible observar radiográficamente la regresión de la lesión periapical y clínicamente la ausencia de sintomatologia(AU)

Difficulties faced by nurses to use pain as the fifth vital sign and the mechanisms/actions adopted: an integrative review / Dificuldades enfrentadas pela enfermagem na aplicabilidade da dor como quinto sinal vital e os mecanismos/ações adotados: revisão integrativa

ABSTRACT BACKGROUND AND OBJECTIVES: Pain was recognized as the fifth vital sign in 1996, and many nurses have difficulty in evaluating it. Since it is necessary to know the difficulties to use pain as a fifth vital sign, this study aims at acquiring a better knowledge about pain, assessment methods and strategies/actions to guarantee its control. The objective of this study was to identify and analyze, in the Brazilian and international literature, the difficulties faced by nurses to use pain as the fifth vital sign and the mechanisms/actions adopted. CONTENTS: It is an integrative review in which the search for scientific articles was carried out in LILACS, BDENF, Scielo, Pubmed, Scopus and Web of Science databases, using the descriptors nursing, pain, and pain and vital signs management in Portuguese, English, and Spanish. The selection criteria were the period from 1995 to 2017 in the three languages mentioned. After searching and reading the articles, nine studies were included. Two categories were listed after reading the articles: 1) difficulties faced by nurses to use pain as a fifth vital sign and 2) mechanisms/actions adopted to minimize the difficulties faced by nurses to use pain as a fifth vital sign. CONCLUSION: It was evidenced that it is important that nurses consider/assess pain as the fifth vital sign, therefore aiming at better care, which, consequently, will influence the quality of care provided, improving patient's health and quality of life.

RESUMO JUSTIFICATIVA E OBJETIVOS: A dor foi reconhecida como quinto sinal vital em 1996 e muitos enfermeiros têm dificuldades em avaliá-la. Mediante a necessidade de conhecer as dificuldades na aplicabilidade da dor como quinto sinal vital, justifica-se este estudo com o intuito de conhecer a dor, os métodos para avaliação e as estratégias/ações para garantir seu controle. O objetivo deste estudo foi identificar e analisar, na literatura brasileira e internacional, as dificuldades enfrentadas pela enfermagem na aplicabilidade da dor como quinto sinal vital e os mecanismos/ações adotados. CONTEÚDO: Trata-se de uma revisão integrativa em que a busca de artigos científicos foi realizada nas bases e bancos de dados: LILACS, BDENF, Scielo, Pubmed, Scopus e Web of Science. Utilizou-se os descritores enfermagem, dor, manuseio da dor e sinais vitais nos idiomas português, inglês e espanhol. Definiu-se como critérios de seleção o período de 1995 a 2017 e os três idiomas citados; e após a busca e a leitura dos artigos foram incluídos nove estudos. Com a leitura dos artigos foram elencadas duas categorias: 1) dificuldades enfrentadas pela enfermagem na aplicabilidade da dor como quinto sinal vital e 2) mecanismos/ações adotados para amenizar as dificuldades enfrentadas pela enfermagem na aplicabilidade da dor como quinto sinal vital. CONCLUSÃO: Evidenciou-se que é necessário que os profissionais enfermeiros atentem para a importância de considerar/avaliar a dor como quinto sinal vital, visando um melhor atendimento que, consequentemente, influenciará na qualidade da assistência prestada, melhorando a saúde e a qualidade de vida do paciente.

Wooly hair nevus.

Woolly hair nevus is a rare condition characterized by a structural anomaly of the hair, restricted to certain areas of the scalp. The hair becomes coiled and slightly hypopigmented. The term woolly hair refers to changes that affect all the scalp and has a hereditary character. We present a case of woolly hair nevus, that developed at the age of 2 years, associated with dental diastema and verrucous epidermal nevus.

Antibodies against rabies virus in dogs with and without history of vaccination in Santa Maria - RS - Brazil / Anticorpos contra o vírus da raiva em cães com e sem histórico de vacinação em Santa Maria - RS - Brasil

ABSTRACT: The present study investigated the frequency and magnitude of neutralizing antibodies to rabies virus (RABV) in dogs with and without historic of vaccination in Santa Maria/RS. Group A included serum samples from 440 dogs with recent historic of vaccination against rabies, obtained during the 2015 rabies vaccination campaign. Group B included 300 serum samples from dogs submitted to the Veterinary Hospital of the Universidade Federal de Santa Maria in 2015, whose historic of rabies vaccination was unknown. Serum samples were submitted to the rapid fluorescent focus inhibition test (RFFIT) to detect neutralizing antibodies against RABV. In group A, 70.6% (310/440) of the samples had neutralizing antibody titers ≥0.5 international units per milliliter (IU mL-1), considered an indicative of protection against rabies by the World Health Organization. However, approximately 30% of the dogs did not contain antibodies in adequate levels. In group B, 42.3% (127/300) of the samples contained neutralizing antibody titers ≥0.5IU mL-1 and 57.7% (173/300) were negative or contained titers below of the value considered immunized. These results demonstrate that an important proportion of vaccinated dogs (~30%) did not develop adequate antibody levels, mainly those receiving a single vaccine dose. Serologic testing of animals with unknown historic of vaccination revealed relatively low vaccine coverage in the general dog population. Thus, reformulation of immunization strategies - especially the recommendation of a boost vaccination 30 days after the primary dose - and extension of vaccination campaigns are necessary to reach adequate levels and coverage of immunity against RABV in the canine population.

RESUMO: O presente estudo investigou a frequência e a magnitude dos anticorpos neutralizantes do vírus da raiva (RABV) em cães com e sem histórico de vacinação em Santa Maria/RS. O Grupo A incluiu amostras de soro de 440 cães com histórico recente de vacinação contra a raiva, obtidos durante a campanha de vacinação contra a raiva de 2015. O Grupo B incluiu 300 amostras de cães submetidos ao Hospital Veterinário da Universidade Federal de Santa Maria em 2015, cujo histórico de vacinação antirrábica era desconhecido. As amostras de soro foram submetidas ao teste rápido de inibição de focos fluorescentes para detecção de anticorpos neutralizantes do RABV. No grupo A, 70,6% (310/440) das amostras possuíam títulos de anticorpos neutralizantes ≥0,5 unidades internacionais por mililitro (UI mL-1), considerado um indicador de proteção contra a raiva pela Organização Mundial da Saúde. No entanto, aproximadamente 30% dos animais não continham anticorpos em níveis adequados. No grupo B, 42,3% (127/300) das amostras continham títulos de anticorpos neutralizantes ≥0,5UI mL-1 e 57,7% (173/300) eram negativas ou continham títulos abaixo do valor considerado imunizado. Estes resultados demonstram que uma proporção importante de cães vacinados (~30%) não desenvolveu níveis adequados de anticorpos, principalmente aqueles que receberam uma única dose de vacina. O teste sorológico de animais com histórico de vacinação desconhecido revelou uma cobertura vacinal relativamente baixa na população geral de cães. Assim, a reformulação das estratégias de imunização - especialmente a recomendação de uma vacinação de reforço 30 dias após a primeira dose - e a extensão das campanhas de vacinação são necessárias para atingir níveis e cobertura adequados de imunidade contra o RABV na população canina.

Percepção de qualidade de vida de catadores de materiais recicláveis / Perception of quality of life collectors of recyclable materials

Objetivo: investigar a percepção da qualidade de vida dos catadores de materiais recicláveis, correlacionando-a às condições de vida e trabalho dos mesmos. Método: estudo descritivo, de abordagem quantitativa, realizado com 37 catadores de recicláveis. Utilizaram-se dois instrumentos, um para a caracterização da amostra e outro para a avaliação da qualidade de vida (WHOQOL–Bref), e os dados foram analisados no software SPSS. Resultados: foram entrevistados 37 catadores de 20 a 71 anos (média 44,16 e dp13,45); 24 (64,86%) tinham companheiros e 14 (37,84%) sentiam dores regularmente. Quanto à percepção da qualidade de vida, os com companheiros tiveram média superior no domínio psicológico em relação aos sem companheiros e negros tiveram médias superiores nos domínios psicológico e social em relação aos brancos e pardos, respectivamente. Conclusão: são necessárias ações preventivas e intervencionistas nos contextos laborais e de vida dos catadores.

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae).

Background. Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. R. Anderson is an Amazonian species almost not studied. Objective. To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves. Materials and Methods. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays. Results. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples. B. duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg-1) showed significant analgesic activity. Conclusion. B. duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.

Wooly hair nevus

Abstract Woolly hair nevus is a rare condition characterized by a structural anomaly of the hair, restricted to certain areas of the scalp. The hair becomes coiled and slightly hypopigmented. The term woolly hair refers to changes that affect all the scalp and has a hereditary character. We present a case of woolly hair nevus, that developed at the age of 2 years, associated with dental diastema and verrucous epidermal nevus.

Linear IgA and IgG bullous dermatosis

Abstract Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.

Linear IgA and IgG bullous dermatosis.

Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.

Persistent docetaxel-induced supravenous erythematous eruption.

Taxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis. Signs of skin toxicity are observed in about 65% of cases and include alopecia, hypersensitivity reactions, persistent supravenous erythematous eruption, nail changes, scleroderma reactions and others. We report two cases of skin reaction to docetaxel and warn that it is not necessary to interrupt the treatment in these cases.

Persistent docetaxel-induced supravenous erythematous eruption

AbstractTaxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis. Signs of skin toxicity are observed in about 65% of cases and include alopecia, hypersensitivity reactions, persistent supravenous erythematous eruption, nail changes, scleroderma reactions and others. We report two cases of skin reaction to docetaxel and warn that it is not necessary to interrupt the treatment in these cases.

Nevo sebáceo de Jadassonh / Sebaceous nevus of Jadassonh

O nevo sebáceo de Jadassonh é um nevo epidérmico composto por glândulas sebáceas de coloração rosa ou amarelada, que pode apresentar o desenvolvimento de várias neoplasias benignas e malignas. É uma das malformações anexais que ocorre com maior frequência nas crianças1,2. Clinicamente aparece como uma placa bem definida de alopecia no couro cabeludo, face ou colo. Está presente desde o nascimento ou pode surgir alguns anos mais tarde1. Apresentamos o caso de um nevo sebáceo de Jadassohn no couro cabeludo a partir do qual um carcinoma basocelular se desenvolveu e foi diagnosticado com o auxílio da dermatoscopia.

Do you know this syndrome?

Cowden's disease or multiple hamartoma syndrome is an autosomal dominant inherited disease and the main dermatological features are facial trichilemmomas (hamartomas of the follicular infundibula), oral fibroma and benign acral keratoses. The importance of this disease lays in the increased susceptibility to malignization of some lesions, especially breast, thyroid and genitourinary tract. Despite its varied phenotypic expression, this disease is generally unknown. Consequently, many cases are undiagnosed or diagnosis comes at a late stage, which reinforces the importance of an early investigation of the disease so the patient may have periodic check-ups to discover and treat malignancies.