Toward Light-Controlled Supramolecular Peptide Dimerization.

The selective photodeprotection of the NVoc-modified FGG tripeptide yields the transformation of its 1:1 receptor-ligand complex with cucurbit[8]uril into a homoternary FGG2@CB8 assembly. The resulting light-induced dimerization of the model peptide provides a tool for the implementation of stimuli-responsive supramolecular chemistry in biologically relevant contexts.

Light-induced cargo release from a cucurbit[8]uril host by means of a sequential logic operation.

The logically controlled and light-induced release of a tripeptide model cargo from a cucurbit[8]uril host macrocycle by means of a photoswitch was shown in water. This provides a new approach to photoresponsive and selective release in a meaningful pH window.