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Contact Dermatitis ; 79(5): 276-280, 2018 Nov.
Article in English | MEDLINE | ID: mdl-30009460

ABSTRACT

BACKGROUND: Panthenol (synonym: dexpanthenol), the alcohol analogue of panthothenic acid, is frequently included in moisturizers, wound-healing agents, and other cosmetics, and has been shown to be responsible for allergic contact dermatitis (ACD). OBJECTIVES: To evaluate the frequency of ACD caused by dexpanthenol, and to characterize reactive patients. METHODS: We retrospectively reviewed the files of patients patch tested between 2009 and 2017 in the Department of Dermatology of the Coimbra's University Hospital and describe patients who reacted to dexpanthenol 5% pet., tested initially in a cosmetic/vehicle series and in the last 3 years in consecutive patients. RESULTS: Among 2171 patients, 26 (1.2%) had positive patch test reactions to dexpanthenol, mostly patients tested for chronic eczema (88.5%, n = 23), either widespread (5), or localized to the hands (5), face (4), or legs (7). Relevance could be traced in 20 patients (76.9%), related to the use of Bepanthene cream (15), moisturizers (3), topical medications (1), and a shampoo (1). Twenty-five of 26 patients (96.2%) reacted to several other allergens, mostly ingredients of cosmetic or pharmaceutical products. CONCLUSIONS: Although ACD caused by dexpanthenol is considered to be rare, it may be frequently overlooked. As we found a relatively high frequency of relevant cases, in agreement with a previous study, the inclusion of dexpanthenol in patch test series, at least in cosmetic and topical drug series, is encouraged.


Subject(s)
Allergens/adverse effects , Dermatitis, Allergic Contact/etiology , Pantothenic Acid/analogs & derivatives , Vitamin B Complex/adverse effects , Administration, Cutaneous , Adolescent , Adult , Aged , Dermatologic Agents/adverse effects , Female , Hair Preparations/adverse effects , Humans , Male , Middle Aged , Pantothenic Acid/adverse effects , Patch Tests , Retrospective Studies , Skin Cream/adverse effects , Wound Healing/drug effects , Young Adult
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