ABSTRACT
TITLE: Efectos tiroideos del tratamiento con biotina.
Subject(s)
Biotin/pharmacology , Thyroid Function Tests , Diagnostic Errors , Humans , Male , Middle AgedABSTRACT
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications for embryonic development, especially in the nervous system where it regulates the balance between proliferation and differentiation of neural progenitors. The DYRK1A gene is located in the Down syndrome critical region and may play a significant role in the developmental brain defects, early neurodegeneration, and cancer susceptibility of individuals with this syndrome. DYRK1A is also expressed in adults, where it might participate in the regulation of cell cycle, survival, and tumorigenesis, thus representing a potential therapeutic target for certain types of cancer. However, the final readout of DYRK1A overexpression or inhibition depends strongly on the cellular context, as it has both tumor suppressor and oncogenic activities. Here, we will discuss the functions and substrates of DYRK1A associated with the control of cell growth and tumorigenesis with a focus on the potential use of DYRK1A inhibitors in cancer therapy.
ABSTRACT
The risk of infectious endocarditis is higher for intravenous drug users than for patients with either rheumatic disease or valve prostheses. We report the case of a 33-year-old woman who self-administered opioid drugs parenterally and who developed a clinical picture of infectious endocarditis. Serious involvement of the tricuspid valve developed in the form of vegetation requiring surgical repair, during which transesophageal echocardiography was used for perioperative monitoring.
Subject(s)
Echocardiography, Transesophageal , Endocarditis, Bacterial/surgery , Heart Valve Prosthesis Implantation , Monitoring, Intraoperative/methods , Staphylococcal Infections/surgery , Tricuspid Valve Insufficiency/surgery , Adult , Endocarditis, Bacterial/diagnostic imaging , Endocarditis, Bacterial/etiology , Female , Humans , Methadone/therapeutic use , Staphylococcal Infections/etiology , Substance Abuse, Intravenous/complications , Substance Abuse, Intravenous/drug therapy , Tricuspid Valve Insufficiency/diagnostic imaging , Tricuspid Valve Insufficiency/etiologyABSTRACT
No disponible
Subject(s)
Humans , Research Design , Spain , Multicenter Studies as Topic , Macrolides , Physicians, Family , Respiratory Tract Infections , Retrospective Studies , Surveys and Questionnaires , Random Allocation , Anti-Bacterial Agents , Drug Utilization , Data Collection , Practice Patterns, Physicians' , Lung Diseases, ObstructiveABSTRACT
El riesgo de endocarditis infecciosa entre los consumidores de drogas por vía intravenosa es superior al que pudieran presentar los pacientes afectados de enfermedad reumática o prótesis valvulares. Presentamos el caso de una mujer de 33 años de edad, consumidora de opiáceos por vía parenteral, que presentó cuadro de endocarditis infecciosa con importante afección de la válvula tricúspide en forma de gran vegetación que requirió tratamiento quirúrgico reparador, durante el cual se realizó monitorización perioperatoria mediante ecocardiografía transesofágica (AU)
No disponible
Subject(s)
Adult , Female , Humans , Echocardiography, Transesophageal , Heart Valve Prosthesis Implantation , Staphylococcal Infections , Tricuspid Valve Insufficiency , Monitoring, Intraoperative , Substance Abuse, Intravenous , Methadone , Endocarditis, BacterialABSTRACT
OBJECTIVES: The aim of this study was to know the opinion of Spanish primary care physicians regarding various aspects of diagnosis and treatment of chronic obstructive pulmonary disease (COPD), particularly with regard to bacterial infection in COPD. METHODS: A 20-item questionnaire about diagnostic and therapeutic aspects of COPD was distributed to 15,000 primary care physicians. The sample was stratified to be representative of Spanish geographic areas. Participation was voluntary and no incentive was provided; assurance of confidentiality of information given. A specially designed program was used for data analysis. RESULTS: Valid responses were obtained from 1,852 physicians (12.3%), 86% of whom were practicing in public clinics. Increased coughing with mucopurulent expectoration was considered the most important sign leading to suspicion of respiratory infection according to 70% of the respondents. The germs that primary care physicians thought responsible for infection in most cases were H. influenzae (83%), S. pneumoniae (79%), Pseudomonas (65%) and M. catarrhalis (61%). Antimicrobial spectrum was considered the main criterion for choosing an antibiotic (by 91%). The most frequently prescribed antibiotics were by order of preference: amoxicillin-clavulanic (50%), macrolides (24%), second and third generation cephalosporins (15%) and others. Mean duration of treatment was seen to be 10 days in nearly all cases. CONCLUSIONS: The primary care physicians surveyed were shown to have a good level of understanding of bacterial infection and its treatment in COPD.
Subject(s)
Bacterial Infections/drug therapy , Bacterial Infections/etiology , Lung Diseases, Obstructive/complications , Practice Patterns, Physicians' , Humans , Primary Health Care , Spain , Surveys and QuestionnairesABSTRACT
Objetivos: Conocer la opinión de médicos de atención primaria españoles, respecto a distintos aspectos diagnósticos y terapéuticos relacionados con la EPOC, con especial énfasis en la infección bacteriana. Métodos: Se distribuyó un cuestionario con 20 preguntas sobre aspectos diagnósticos y terapéuticos de la EPOC a un total de 15.000 médicos de atención primaria, elegidos mediante un muestreo razonado estratificado por zonas geográficas de España. La participación en el estudio fue voluntaria y no incentivada y se garantizó la confidencialidad de la información aportada. El análisis de los datos se realizó mediante un programa informático diseñado al efecto. Resultados: Se obtuvieron respuestas válidas de 1.852 médicos (12,3 por ciento). El 86 por ciento ejercía en centros públicos. El 70 por ciento de los encuestados consideró el aumento de la tos con expectoración mucopurulenta como la manifestación más importante de sospecha de infección respiratoria. Los gérmenes que los médicos de atención primaria opinan que son los responsables de las agudizaciones con mayor frecuencia son: H. influenzae (83 por ciento), S. pneumoniae (79 por ciento) y M. catharralis (61 por ciento). El espectro antimicrobiano se consideró como criterio fundamental para escoger el antibiótico (91 por ciento). Los antibióticos más utilizados fueron por orden de preferencia: amoxicilina-clavulánico (50 por ciento), macrólidos (24 por ciento), cefalosporinas de segunda y tercera generación (15 por ciento) y otros. La duración del tratamiento se estableció en una media de 10 días de forma casi universal. Conclusiones: Los médicos de atención primaria encuestados han demostrado un buen conocimiento de la infección bacteriana en la EPOC y de su adecuado tratamiento. (AU)
