ABSTRACT
CONTEXT: Obesity may be regarded as a low-grade inflammatory state. OBJECTIVE: The aim of this study was to evaluate changes in pro-inflammatory adipocytokines and the innate immune system, cardiovascular risk, and insulin sensitivity after massive weight loss. DESIGN: This was a longitudinal study. SETTING: The study was conducted at Catholic University, Rome. SUBJECTS AND METHODS: There were 10 normoglucose-tolerant obese women evaluated before and 36 months after bilio-pancreatic diversion (BPD). Glucose sensitivity (M value) was estimated using the euglycemic-hyperinsulinemic clamp. Mannan-binding lectin (MBL), bactericidal/permeability increasing protein (BPI), alpha-defensins, soluble CD14 receptor (sCD14), C-reactive protein, adiponectin, leptin, visfatin, IL-6, and TNF-alpha were assayed. RESULTS: After massive weight loss (53% of excess body weight), leptin (P Subject(s)
Adipocytes/immunology
, Cytokines/immunology
, Obesity, Morbid/immunology
, Obesity, Morbid/surgery
, Weight Loss/immunology
, Acute-Phase Reaction/immunology
, Adiponectin/blood
, Adult
, Antimicrobial Cationic Peptides/blood
, Blood Glucose/metabolism
, Blood Proteins
, Body Composition/immunology
, C-Reactive Protein/metabolism
, Cytokines/blood
, Female
, Humans
, Immune System/physiology
, Insulin Resistance/immunology
, Interleukin-6/blood
, Leptin/blood
, Lipopolysaccharide Receptors/blood
, Longitudinal Studies
, Mannose-Binding Lectin/blood
, Membrane Proteins/blood
, Middle Aged
, Nicotinamide Phosphoribosyltransferase
, Solubility
, Tumor Necrosis Factor-alpha/blood
, alpha-Defensins/blood
