ABSTRACT
Pseudomonas aeruginosa (PA) is a Gram-negative germ, responsible for severe infections. PA infected chronic wounds are a clinically highly relevant topic. PA has a natural resistance to many antibiotics, and there is no consensus on a first-line antibiotic to be used. In the context of chronic ulcers with an unfavorable evolution, we suggest intravenous antibiotic therapy, ideally on an in-patient basis. Given the sparse evidence from clinical trials, we heavily rely on clinical experience when it comes to managing chronic ulcers infected with PA.
Subject(s)
Leg Ulcer/pathology , Pseudomonas Infections/pathology , Pseudomonas aeruginosa/isolation & purification , Anti-Bacterial Agents/therapeutic use , Chronic Disease , Drug Resistance, Bacterial , Humans , Leg Ulcer/drug therapy , Leg Ulcer/microbiology , Pseudomonas Infections/drug therapy , Pseudomonas Infections/microbiologySubject(s)
Common Variable Immunodeficiency/drug therapy , Immunoglobulins, Intravenous/therapeutic use , Immunologic Factors/therapeutic use , Necrobiosis Lipoidica/drug therapy , Skin Ulcer/drug therapy , Common Variable Immunodeficiency/complications , Diabetes Complications/drug therapy , Female , Humans , Leg , Middle Aged , Necrobiosis Lipoidica/complications , Skin Ulcer/complicationsABSTRACT
The erythema scarlatiniforme desquamtivum recidivans (ESDR) is rare condition, characterized by an erythema followed by large lamellar scaling. Two variants are described, a generalized and localized one. The generalized variant initially presents with fever, flue-like symptoms followed by a widespread macular erythema rapidly evolving into large lamellar scaling, except for the head where scaling is finer. The localized form is often asymptomatic and the large lamellar scaling is limited to the palms and soles. ESDR can recur within weeks or years after the first outbreak, with the localized form being more frequent at recurrence. The aetiology remains unknown. Most authors agree on a hyperergic reaction to drugs, viral and bacterial infections. Differential diagnosis includes several conditions. The medical history and the striking presentation help in making the diagnosis.