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AIDS ; 18(7): 1071-4, 2004 Apr 30.
Article in English | MEDLINE | ID: mdl-15096813

ABSTRACT

The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.


Subject(s)
Acquired Immunodeficiency Syndrome/immunology , HIV Seronegativity , HIV-1/classification , Acquired Immunodeficiency Syndrome/virology , Adult , Female , HIV-1/genetics , HIV-1/immunology , Humans , Phylogeny
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