ABSTRACT
Systemic Lupus Erythematosus (SLE) is an autoimmune disease, with multisystemic involvement. Gastrointestinal symptoms are common, like nausea, vomiting and dyspepsia. Acute pancreatitis is an unusual manifestation of SLE, being an important differential diagnosis in evaluation of abdominal pain. The patients usually presents with pain of variable intensity, some occasions simulating acute abdomen. Several factors have been implicated in the pathogenesis of this condition, such as vasculitis, drugs and antiphospholipid antibodies. The role of corticosteroids as etiologic factor remains controversial. Due to the rarity of SLE associated to pancreatitis, we report two cases of patients with severe inflammatory process. In one case, it was used corticosteroids in high doses during treatment, with good outcome. In another, the patient died because of pancreatic pseudocyst rupture and its postoperative hemodynamic complications. In the reported cases, predisposing factors for acute pancreatitis were not verified, so it was considered a primary manifestation of SLE activity.
Subject(s)
Lupus Erythematosus, Systemic/complications , Pancreatic Pseudocyst/etiology , Pancreatitis/etiology , Acute Disease , Adult , Female , Humans , Pancreatic Pseudocyst/complications , Rupture, Spontaneous , Young AdultABSTRACT
OBJECTIVE: To determine the prevalence of congenital anterior chest wall deformities in 11- to 14-year-old students. METHODS: Students participating in the study were recruited from public schools in the city of Manaus, Brazil. The statistically significant sample (precision, 1%; 95% CI) comprised 1,332 students. Pectus deformities were identified by physical examination of the chest, and the individuals with one of these deformities completed a questionnaire regarding heredity and symptoms resulting from the chest abnormality. RESULTS: The mean age of the participants was 11.7 years. The prevalence of pectus abnormalities was 1.95% (pectus excavatum: 1.275%; pectus carinatum: 0.675%). Of the 26 students with a pectus deformity, 17 (65.4%) had pectus excavatum, and 18 (69.2%) were male. Concomitant scoliosis was observed in 3 cases (11.5%). A family history of pectus was reported by 17 students (65.4%), and 17 (65.4%) reported chest pain, dyspnea or palpitations. CONCLUSIONS: In this study, the prevalence of pectus deformities (1.95%) was lower than that reported in other studies conducted in Brazil (3.6-4.9%) but was higher than that reported in the literature (mean, 1%).
Subject(s)
Funnel Chest/epidemiology , Musculoskeletal Abnormalities/epidemiology , Thoracic Wall/abnormalities , Adolescent , Brazil/epidemiology , Child , Female , Funnel Chest/diagnosis , Humans , Male , Musculoskeletal Abnormalities/classification , Musculoskeletal Abnormalities/diagnosis , Prevalence , Reproducibility of Results , StudentsABSTRACT
OBJETIVO: Determinar a prevalência das deformidades congênitas da parede torácica anterior em escolares de 11 a 14 anos. MÉTODOS: Participaram do estudo escolares da rede estadual de ensino da cidade de Manaus (AM). Para a composição de uma amostra estatisticamente significativa, com precisão de 1 por cento e IC95 por cento, foram incluídos 1.332 escolares. A deformidade pectus foi identificada através de exame físico do tórax, e os indivíduos com esta deformidade responderam a um questionário com questões sobre hereditariedade e sintomatologia decorrente da anomalia torácica. RESULTADOS: A idade média dos participantes foi de 11,7 anos. A prevalência da deformidade pectus foi de 1,95 por cento (pectus excavatum: 1,275 por cento; pectus carinatum: 0,675 por cento). Dos 26 escolares com deformidades pectus, 17 (65,4 por cento) tinham pectus excavatum, e 18 (69,2 por cento) eram do sexo masculino. Houve associação com a escoliose em 3 casos (11,5 por cento). História familiar de pectus foi relatada por 17 escolares (65,4 por cento), e 17 (65,4 por cento) relataram dor torácica, dispneia ou palpitações. CONCLUSÕES: A prevalência das deformidades pectus encontrada neste estudo (1,95 por cento) foi inferior àquela de trabalhos em outras regiões do país (3,6-4,9 por cento), porém, superior àquela relatada na literatura (média, 1 por cento).
OBJECTIVE: To determine the prevalence of congenital anterior chest wall deformities in 11- to 14-year-old students. METHODS: Students participating in the study were recruited from public schools in the city of Manaus, Brazil. The statistically significant sample (precision, 1 percent; 95 percent CI) comprised 1,332 students. Pectus deformities were identified by physical examination of the chest, and the individuals with one of these deformities completed a questionnaire regarding heredity and symptoms resulting from the chest abnormality. RESULTS: The mean age of the participants was 11.7 years. The prevalence of pectus abnormalities was 1.95 percent (pectus excavatum: 1.275 percent; pectus carinatum: 0.675 percent). Of the 26 students with a pectus deformity, 17 (65.4 percent) had pectus excavatum, and 18 (69.2 percent) were male. Concomitant scoliosis was observed in 3 cases (11.5 percent). A family history of pectus was reported by 17 students (65.4 percent), and 17 (65.4 percent) reported chest pain, dyspnea or palpitations. CONCLUSIONS: In this study, the prevalence of pectus deformities (1.95 percent) was lower than that reported in other studies conducted in Brazil (3.6-4.9 percent) but was higher than that reported in the literature (mean, 1 percent).
