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1.
Genet Mol Res ; 13(3): 4820-30, 2014 Jul 02.
Article in English | MEDLINE | ID: mdl-25062417

ABSTRACT

We evaluated the effects of glutamine on clastogenic and genotoxic damage prevention caused by the administration of cisplatin. Forty Swiss mice were divided into 8 experimental groups: G1 and G2, which were control groups; G3, G4, and G5, which were administered [2 doses of glutamine (orally)] separated by a 24-h period (150, 300, and 600 mg/kg, respectively), and a dose of phosphate-buffered saline by intraperitoneal injection; G6, G7, and G8, which were treated in the same manner as the previous groups, but received cisplatin rather than phosphate-buffered saline. The antimutagenicity groups showed damage reduction percentages of 79.05, 80.00, and 94.27% at the time point T1, 53.18, 67.05, and 64.74 at time point T2 for the 150, 300, and 600 mg/kg doses of glutamine, respectively. Antigenotoxic activity was evident for all 3 doses with damage reduction percentages of 115.05, 119.06, and 114.38 for the doses of glutamine of 150, 300, and 600 mg/ kg, respectively. These results suggest that further studies are needed to confirm the clastogenic activity of glutamine. However, our results may lead to rational strategies for supplementation of this antioxidant as an adjuvant in cancer treatment or for preventing genomic lesions.


Subject(s)
Antimutagenic Agents/pharmacology , Antioxidants/pharmacology , Cisplatin/pharmacology , Glutamine/pharmacology , Mutagens/pharmacology , Animals , Antineoplastic Agents/pharmacology , Cisplatin/antagonists & inhibitors , Comet Assay , DNA Damage , Injections, Intraperitoneal , Male , Mice , Micronucleus Tests
2.
Braz. j. biol ; 68(4): 799-805, Nov. 2008. ilus, graf, mapas, tab
Article in English | LILACS | ID: lil-504497

ABSTRACT

The "tucunaré", Cichla piquiti, an exotic Amazonian fish has become established along the left bank of the Paraguay River in the Pantanal. It was introduced by escaping from culture ponds in the Upper Piquiri River and spread downstream, along the lateral flooded areas of that river, continuing through the clear waters of the left bank of the Paraguay River and reaching south as far as the Paraguai Mirim and Negrinho rivers. Adult spawners have been found in the region, meaning that it is a self-sustained population. Reproduction occurs in the period of low waters. They were found feeding on fishes of lentic environments belonging to the families Characidae, Cichlidae and Loricariidae. Until the end of 2004, its distribution was restricted to the left bank of the Paraguay River, but in March 2005, some specimens were found on the right bank, raising a question for the future: what will be the distribution area of the tucunaré in the Pantanal? Information about its dispersion is increasing: it is known to be in the Tuiuiú Lake, Pantanal National Park and in the Bolivian Pantanal, all of them on the right bank of the Paraguay River. The hypothesis that the "tucunaré" could not cross turbid waters, such as in the Paraguay River, was refuted by these recent findings. Possibly, the tucunaré's capacity to lay more than one batch of eggs in a reproductive period, as well as its care of eggs and young, lead them to establish themselves successfully in new environments, as has been observed in the Pantanal and other localities.


O tucunaré, Cichla piquiti, está estabelecido ao longo da margem esquerda do rio Paraguai, desde a área do seu escape no rio Piquiri para jusante, até as áreas alagadas laterais entre os rios Paraguai Mirim e Negrinho. Está completando o seu ciclo de vida no Pantanal com populações adultas desovantes. A reprodução ocorre no período de águas baixas. Na região em estudo, alimentou-se de peixes de ambientes lênticos das famílias Characidae, Cichlidae e Loricariidae. Até fins de 2004, sua ocorrência estava restrita à margem esquerda do rio Paraguai, mas, nos primeiros dias de Março de 2005, alguns indivíduos foram pescados na margem direita, o que coloca uma questão a ser respondida nos próximos anos: qual será efetivamente a sua distribuição no Pantanal? A hipótese inicial de que as águas turvas do rio Paraguai constituiriam barreiras a sua dispersão não foi confirmada. Já existem registros de ocorrência na Baía Tuiuiú, Parque Nacional do Pantanal e no Pantanal boliviano, todos eles localizados na margem direita do rio Paraguai. O tucunaré possui características biológicas como desova parcelada e cuidados com a prole, entre outras, que lhe está possibilitando estabelecer-se com sucesso no Pantanal, a exemplo do que já foi observado em outros ambientes onde foi introduzido.


Subject(s)
Animals , Female , Male , Fishes/physiology , Rivers , Brazil , Feeding Behavior/physiology , Fishes/classification , Population Dynamics
3.
Braz J Biol ; 68(4): 799-805, 2008 Nov.
Article in English | MEDLINE | ID: mdl-19197497

ABSTRACT

The 'tucunaré', Cichla piquiti, an exotic Amazonian fish has become established along the left bank of the Paraguay River in the Pantanal. It was introduced by escaping from culture ponds in the Upper Piquiri River and spread downstream, along the lateral flooded areas of that river, continuing through the clear waters of the left bank of the Paraguay River and reaching south as far as the Paraguai Mirim and Negrinho rivers. Adult spawners have been found in the region, meaning that it is a self-sustained population. Reproduction occurs in the period of low waters. They were found feeding on fishes of lentic environments belonging to the families Characidae, Cichlidae and Loricariidae. Until the end of 2004, its distribution was restricted to the left bank of the Paraguay River, but in March 2005, some specimens were found on the right bank, raising a question for the future: what will be the distribution area of the tucunaré in the Pantanal? Information about its dispersion is increasing: it is known to be in the Tuiuiú Lake, Pantanal National Park and in the Bolivian Pantanal, all of them on the right bank of the Paraguay River. The hypothesis that the 'tucunaré' could not cross turbid waters, such as in the Paraguay River, was refuted by these recent findings. Possibly, the tucunaré's capacity to lay more than one batch of eggs in a reproductive period, as well as its care of eggs and young, lead them to establish themselves successfully in new environments, as has been observed in the Pantanal and other localities.


Subject(s)
Fishes/physiology , Rivers , Animals , Brazil , Feeding Behavior/physiology , Female , Fishes/classification , Male , Population Dynamics
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