ABSTRACT
The oxidative pathway and the alteration of the antioxidant defense have drawn attention to the pathophysiology of cervical cancer (CC). In our preliminary study, it was possible to corroborate the findings regarding the antioxidants of patients affected by CC. The total antioxidant activity and lipid peroxidation (LP) were evaluated in 14 people diagnosed with CC and 14 volunteers without CC (control group). Results showed low antioxidant activity in CC group. LP was not significant when analyzing CC group and control group. Our results indicate that changes in antioxidant defense may contribute to the pathophysiology of CC.
Subject(s)
Antioxidants , Uterine Cervical Neoplasms , Antioxidants/metabolism , Female , Humans , Lipid Peroxidation , Oxidation-Reduction , Oxidative Stress , Uterine Cervical Neoplasms/metabolismABSTRACT
Malaria is a significant public health problem in more than 100 countries and causes an estimated 200 million new infections every year. Despite the significant effort to eradicate this dangerous disease, lack of complete knowledge of its physiopathology compromises the success in this enterprise. In this paper we review oxidative stress mechanisms involved in the disease and discuss the potential benefits of antioxidant supplementation as an adjuvant antimalarial strategy.
Subject(s)
Malaria/immunology , Malaria/metabolism , Oxidative Stress/physiology , Animals , Hemolysis/immunology , Host-Parasite Interactions , Humans , Immunity, Innate/physiology , Nitric Oxide/metabolism , Plasmodium falciparum/immunology , Reactive Oxygen Species/metabolismABSTRACT
Determinar os teores deste alcalóide em suplementos energéticos comercializados nacidade de Belém,Pará. Método: realizou-se um estudo de pesquisa analítico por cromatografialíquida de alta eficiência com detecção no ultravioleta. Resultados: a concentração média decafeína nas amostras analisadas foi 19.2±18.8mg/10mL, com intervalo de 2.45 a 62.4mg/10mLe coeficiente de variação de 98%. Conclusão: os resultados deste estudo demonstraram que osteores de cafeína nos suplementos energéticos não representa riscos a saúde do consumidor,por outro lado indicaram a necessidade da intensificação das medidas regulatórias referentes arotulagem inadequada, composição e controle de qualidade dos componentes
to determine the caffeine contents of 30 samples of energy supplements from Belem, PA, to evaluate the safety of the human consumption. Method: Analysis of caffeine in energy supplements by high performance liquid chromatography with ultraviolet detection. Results:The mean concentration of caffeine in energy supplements was 19.2±18.8mg/10ml ranging from2.45 to 6.24mg/10mL. The variation coefficient was 98%. Conclusion: contents of energy supplements don?t represent a risk for human health, but regulatory approaches for the evaluation of composition and quality control are needs.