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1.
Clin Oral Investig ; 23(7): 2837-2848, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31111285

ABSTRACT

PURPOSE: This study investigated the anti-Candida activity and the Shore A hardness of a tissue conditioner (Softone™) modified by incorporation of terpinen-4-ol and cinnamaldehyde. MATERIAL AND METHODS: Agar diffusion, microdilution, and mechanism of action methods were performed to determine to evaluate the antifungal activity of phytoconstituents. Then, phytoconstituents in varying concentrations were incorporated into the tissue conditioner. The anti-Candida effect of the modified conditioner was evaluated through agar punch well and biofilm formation methods. Shore A hardness of the experimental liners was evaluated after baseline, 24 h, 48 h, 4 days, and 7 days immersion on artificial saliva. RESULTS: The phytoconstituents incorporated into Softone showed completely inhibited fungal growth in concentrations of 20-40% and did not present significant antifungal activity until their concentrations where higher than 5%. There were differences between non-modified Softone and M5, M10, C10, and T10% (p < 0.05). The groups containing 10-40% of cinnamaldehyde incorporated into Softone were able to completely inhibit the biofilm. Concentrations below 40% of terpinen-4-ol showed unsatisfactory biofilm inhibition. The T40% and C40% groups presented the lowest Shore A hardness values. Hardness values from groups T40% at 7 days (p = 0.476); C40% at 4 days (p = 0.058); and T20% (p = 0.058), C20% (p = 0.205), T30% (p = 0.154), and C30% (p = 0.874) after 48 h did not differ from the control group. CONCLUSIONS: Cinnamaldehyde incorporated into Softone inhibited Candida biofilm formation at concentrations of 10-40%, being more effective than terpinen-4-ol modification despite of halo inhibition observed by both products. CLINICAL RELEVANCE: All modifications showed a very similar pattern of hardness being useful for clinical practice.


Subject(s)
Acrolein/analogs & derivatives , Antifungal Agents , Candida albicans , Terpenes , Acrolein/pharmacology , Antifungal Agents/pharmacology , Hardness , Terpenes/pharmacology
2.
Rev Soc Bras Med Trop ; 48(3): 361-3, 2015.
Article in English | MEDLINE | ID: mdl-26108021

ABSTRACT

Oral dirofilariasis is very rare with non-specific clinical manifestations. Here, we report the case of a 65-year-old South American woman with a submucosal nodule on her right buccal mucosa. The nodule was slightly tender and painful. Differential diagnoses included mesenchymal (lipoma or fibrolipoma, solitary fibrous tumor, and neurofibroma) or glandular benign tumors (pleomorphic adenoma) with secondary infections. We performed excisional biopsy. A histopathological examination revealed a dense fibrous capsule and a single female filarial worm showing double uterus appearance, neural plaque, well-developed musculature and intestinal apparatus. Dirofilariasis was diagnosed, and the patient was followed-up for 12 months without recurrence.


Subject(s)
Dirofilariasis , Mouth Diseases/parasitology , Aged , Brazil/epidemiology , Diagnosis, Differential , Dirofilariasis/epidemiology , Dirofilariasis/pathology , Female , Humans , Mouth Diseases/epidemiology , Mouth Diseases/pathology
3.
Rev. Soc. Bras. Med. Trop ; 48(3): 361-363, May-Jun/2015. graf
Article in English | LILACS | ID: lil-749876

ABSTRACT

Oral dirofilariasis is very rare with non-specific clinical manifestations. Here, we report the case of a 65-year-old South American woman with a submucosal nodule on her right buccal mucosa. The nodule was slightly tender and painful. Differential diagnoses included mesenchymal (lipoma or fibrolipoma, solitary fibrous tumor, and neurofibroma) or glandular benign tumors (pleomorphic adenoma) with secondary infections. We performed excisional biopsy. A histopathological examination revealed a dense fibrous capsule and a single female filarial worm showing double uterus appearance, neural plaque, well-developed musculature and intestinal apparatus. Dirofilariasis was diagnosed, and the patient was followed-up for 12 months without recurrence.


Subject(s)
Aged , Female , Humans , Dirofilariasis , Mouth Diseases/parasitology , Brazil/epidemiology , Diagnosis, Differential , Dirofilariasis/epidemiology , Dirofilariasis/pathology , Mouth Diseases/epidemiology , Mouth Diseases/pathology
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