ABSTRACT
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Subject(s)
Humans , Female , Adult , Middle Aged , Vasculitis, Central Nervous System/drug therapy , Pulmonary Eosinophilia/drug therapy , Antibodies, Monoclonal/administration & dosage , Vasculitis, Central Nervous System/diagnostic imaging , Tomography, X-Ray Computed , Pulmonary Eosinophilia/diagnostic imaging , Treatment Outcome , Injections, SubcutaneousSubject(s)
Adenocarcinoma/secondary , Behcet Syndrome/complications , Colonic Neoplasms/complications , Cryptococcosis/diagnosis , Dermatomycoses/diagnosis , Diagnostic Errors , Liver Neoplasms/secondary , Opportunistic Infections/diagnosis , Adenocarcinoma/complications , Adenocarcinoma/diagnosis , Adenocarcinoma/diagnostic imaging , Aged , Antifungal Agents/therapeutic use , Colonic Neoplasms/diagnosis , Cryptococcosis/drug therapy , Cryptococcosis/etiology , Cryptococcosis/surgery , Debridement , Dermatomycoses/drug therapy , Dermatomycoses/etiology , Dermatomycoses/surgery , Fatal Outcome , Fluconazole/therapeutic use , Humans , Incidental Findings , Liver Neoplasms/complications , Liver Neoplasms/diagnostic imaging , Male , Opportunistic Infections/drug therapy , Opportunistic Infections/etiology , Opportunistic Infections/surgery , Radiography , Skin Ulcer/diagnosis , Skin Ulcer/drug therapy , Skin Ulcer/etiology , Skin Ulcer/surgery , Vasculitis, Leukocytoclastic, Cutaneous/diagnosisSubject(s)
Humans , Male , Middle Aged , Cryptococcosis/complications , Cryptococcosis/diagnosis , Behcet Syndrome/complications , Behcet Syndrome/diagnosis , Colonic Neoplasms/complications , Colonic Neoplasms/diagnosis , Vasculitis/complications , Vasculitis, Leukocytoclastic, Cutaneous/complications , Vasculitis, Leukocytoclastic, Cutaneous/diagnosis , Fluconazole/therapeutic use , Cryptococcosis/drug therapy , Cryptococcosis/physiopathology , Cryptococcosis , Cryptococcosis/surgeryABSTRACT
OBJECTIVE: To determine the prevalence of the most often tested autoantibodies in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. METHODS: We identified 90 patients seen in our unit between June 2002 and June 2009, and diagnosed according to the proposed criteria for SAPHO syndrome. Demographic and clinical data were collected as well as immunological results, including antinuclear, antithyroid peroxydase (TPO), antithyroid globulin (Tg), antigastric parietal cell, antismooth muscle, antimitochondria, and anti-liver-kidney microsome (LKM) antibodies. Anticyclic citrullinated peptide (CCP) antibodies were analyzed in 69 patients, antibodies to soluble extractable nuclear antigens in 43, anti-double-stranded DNA (dsDNA) antibodies in 22 [depending on the type of fluorescence of antinuclear antibody (ANA)], and antiendomysium antibodies in 55. RESULTS: Autoantibodies were found in 20 patients (22.2%): 14 patients (15.5%) had positive ANA (titer >/= 1/160); among them, 10 (11%) patients never took a lupus-inducing drug. Antithyroid antibodies (anti-TPO and/or anti-Tg antibodies) were found in only 3 patients (3.3%). Three patients (3.3%) were positive for antigastric parietal cell antibodies and 4 (4.4%) were weakly positive for antismooth muscle antibodies. Antimitochondria and LKM antibodies were negative in all 90 patients. Anti-CCP and anti-dsDNA antibodies were negative in the 69 and 22 patients tested, respectively. One out of 43 patients (2.3%) had anti-SSA antibodies. Antiendomysium antibodies were negative in the 55 patients tested. CONCLUSION: Our study indicates an increased prevalence of autoantibodies in SAPHO syndrome, with no specific profile. We failed to confirm the reports of an increased prevalence of antithyroid antibodies. These results tend to support a link between autoimmunity and SAPHO syndrome.
Subject(s)
Acquired Hyperostosis Syndrome/immunology , Autoantibodies/blood , Autoimmunity/immunology , Acquired Hyperostosis Syndrome/blood , Adolescent , Adult , Aged , Antibodies, Antinuclear/blood , Autoantigens/immunology , DNA/immunology , Female , Humans , Iodide Peroxidase/immunology , Iron-Binding Proteins/immunology , Male , Middle Aged , Muscle, Smooth/immunology , Parietal Cells, Gastric/immunology , Peptides, Cyclic/immunology , Prospective Studies , Retrospective Studies , Young AdultABSTRACT
Livedoid vasculopathy (LV) is an occlusive thrombotic disease that affects primarily the small blood vessels of the coger extremities and often is associated with recurrent painful ulcerations. The pathogenesis of Lvis unclear, but it is attributed to hypercoagulable state. We describe a 27-year old pregnant woman who developed a LV in the third trimester of her pregnancy. The skin biopsy revealed endothelial proliferation and fibrin thrombi in small vessels of the dermis. She had aCl Ig G and Ig M positive and lupus anticoagulant negative. Treatment with heparin, aspirin and steroids was required with dramatically improvement of the lesions